Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

AbstractAerobic training (AT) can promote cognitive function in adults with Subcortical Ischemic Vascular Cognitive Impairment (SIVCI) by modifying cardiovascular risk factors. However, pre-existing cardiovascular health may attenuate the benefits of AT on cognitive outcomes in SIVCI. We examined whether baseline cardiovascular risk moderates the effect of a 6-month progressive AT program on executive functions with a secondary analysis of a randomized controlled trial in 71 adults, who were randomized to either: (1) 3×/week progressive AT; or (2) education program (CON). Three executive processes were measured: (1) response inhibition by Stroop Test; (2) working memory by digits backward test; and (3) set shifting by the Trail Making Test. Baseline cardiovascular risk was calculated using the Framingham cardiovascular disease (CVD) Risk Score (FCRS), and participants were classified as either low risk (< 20% FCRS score; LCVR) or high risk (≥ 20% FCRS score; HCVR). A complete case analysis (n = 58) was conducted using an analysis of covariance (ANCOVA) to evaluate between-group differences in the three executive processes. A significant interaction was found between cardiovascular risk group and intervention group (AT or CON) for the digit span backward and the Trail Making Test. AT improved performance compared with CON in those with LCVR, while in those with HCVR, AT did not improve performance compared with CON. Baseline cardiovascular risk significantly moderates the efficacy of AT on cognition. Our findings highlight the importance of intervening early in the disease course of SIVCI, when cardiovascular risk may be lower, to reap maximum benefits of aerobic exercise.

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O5-04-04: Vascular cognitive impairment and aerobic exercise: A 6-month randomized controlled trial

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.07.466 ◽

2015 ◽

Vol 11 (7S_Part_7) ◽

pp. P323-P324

Author(s):

Teresa Liu-Ambrose ◽

Jennifer Davis ◽

John R. Best ◽

Janice J. Eng ◽

Philip E. Lee ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Impairment ◽

Aerobic Exercise ◽

Controlled Trial ◽

Vascular Cognitive Impairment ◽

Randomized Controlled

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Economic evaluation of aerobic exercise training in older adults with vascular cognitive impairment: PROMoTE trial

BMJ Open ◽

10.1136/bmjopen-2016-014387 ◽

2017 ◽

Vol 7 (3) ◽

pp. e014387 ◽

Cited By ~ 4

Author(s):

Jennifer C Davis ◽

Ging-Yuek Robin Hsiung ◽

Stirling Bryan ◽

John R Best ◽

Janice J Eng ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Economic Evaluation ◽

Exercise Training ◽

Aerobic Exercise ◽

Vascular Cognitive Impairment ◽

Aerobic Exercise Training

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P3-318: The effect of aerobic exercise on fall risk reduction among older adults with mild vascular cognitive impairment

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.1692 ◽

2015 ◽

Vol 11 (7S_Part_16) ◽

pp. P759-P759

Author(s):

Ryan S. Falck ◽

Lisanne ten Brinke ◽

Ging-Yuek Robin Hsiung ◽

Janice J. Eng ◽

Michelle Munkacsy ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Aerobic Exercise ◽

Risk Reduction ◽

Fall Risk ◽

Vascular Cognitive Impairment ◽

Fall Risk Reduction

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Knockdown of lncRNA TUG1 inhibits hippocampal neuronal apoptosis and participates in aerobic exercise-alleviated vascular cognitive impairment

Biological Research ◽

10.1186/s40659-020-00320-4 ◽

2020 ◽

Vol 53 (1) ◽

Author(s):

Jing Wang ◽

Yali Niu ◽

Huaying Tao ◽

Mina Xue ◽

Chunxiao Wan

Keyword(s):

Cognitive Impairment ◽

Aerobic Exercise ◽

Cell Apoptosis ◽

Neuronal Apoptosis ◽

Molecular Mechanisms ◽

Glucose Deprivation ◽

Vascular Cognitive Impairment ◽

Control Group ◽

Therapeutic Effects ◽

Ht22 Cells

Abstract Objectives Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism is not yet clear. This study aimed to explore whether lncRNA taurine upregulated gene 1 (TUG1) participates in the process of VCI by regulating BDNF. Methods The expressions of TUG1 and BDNF in the serum of VCI patients were detected. The potential molecular mechanisms of TUG1 in regulating hippocampal neuronal apoptosis were explored in oxygen and glucose deprivation-induced (OGD-induced) hippocampal cell line HT22. The VCI mouse model was established, and TUG1 and BDNF were overexpressed via lentivirus injection. The cognitive impairment of mice was detected by the Morris water maze experiment after the aerobic exercise. Results The level of TUG1 was elevated in the serum of VCI patients compared with the control group. The knockdown of TUG1 in OGD-induced HT22 cells increased BDNF level and decreased cell apoptosis, and the downregulation of BDNF restored the decreased cell apoptosis. RNA immunoprecipitation and RNA pull-down assays showed that TUG1 could bind to BDNF protein. The aerobic exercise alleviated cognitive impairment and inhibited hippocampal apoptosis in VCI mice. Meanwhile, the overexpression of TUG1 reversed the therapeutic effects of aerobic exercise on cognitive impairment. Conclusions The knockdown of TUG1 reduced hippocampal neuronal apoptosis and participates in the aerobic exercise-alleviated VCI, which was partly through regulating BDNF.

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Sex Difference in Aerobic Exercise Efficacy to Improve Cognition in Older Adults with Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial

Journal of Alzheimer s Disease ◽

10.3233/jad-170221 ◽

2017 ◽

Vol 60 (4) ◽

pp. 1397-1410 ◽

Cited By ~ 17

Author(s):

Cindy K. Barha ◽

Ging-Yuek R. Hsiung ◽

John R. Best ◽

Jennifer C. Davis ◽

Janice J. Eng ◽

...

Keyword(s):

Older Adults ◽

Randomized Controlled Trial ◽

Cognitive Impairment ◽

Aerobic Exercise ◽

Sex Difference ◽

Controlled Trial ◽

Secondary Analysis ◽

Vascular Cognitive Impairment ◽

Randomized Controlled

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Neuroimaging patterns of chronic cerebrovascular insufficiency with evaluation of cerebral perfusion depending on the level of cognitive disorders

Medical Visualization ◽

10.24835/1607-0763-2020-3-114-122 ◽

2020 ◽

Vol 24 (3) ◽

pp. 114-122

Author(s):

E. S. Chukhontseva ◽

T. G. Morozova ◽

A. V. Borsukov

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Cognitive Impairment ◽

Cerebral Perfusion ◽

Cognitive Disorders ◽

Vascular Cognitive Impairment ◽

Perivascular Spaces ◽

Cerebrovascular Insufficiency ◽

Parietal Lobes ◽

Brain Barrier Permeability

Aim. To evaluate the neuroimaging patterns of chronic cerebrovascular insufficiency with cerebral perfusion assessment depending on the level of cognitive impairment.Materials and methods. The 58 patients aged 50–79 years were examined: 45 patients with a diagnosis of сhronic cerebrovascular insufficiency and 13 conditionally healthy volunteers. Patients with Chronic cerebrovascular insufficiency were ranked into three subgroups depending on the severity of cognitive impartment (CI). T1-, T2, T2*- VI, DWI, FLAIR and non-contrast MR perfusion (ASL) were included in the MR-protocol (Toshiba Vantage Titan, 1.5 T). The analysis of MRM patterns of Chronic cerebrovascular insufficiency was carried out according to STRIVE criteria. The total cerebral blood flow and regional in the frontal and parietal lobes were evaluated by the ASLperfusion.Results. A relationship was found between the degree of leukoaraiosis, the type of expansion of the perivascular spaces of Virchow-Robin and the level of CI. According to ASL, total cerebral blood flow is higher in groups without CI and in patients with severe CI. There is a diffuse decrease of cerebral perfusion in patients with mild CI. This phenomenon is explained by initial impairment of the blood-brain barrier permeability, damage to the microvasculature. Relative hyperperfusion in the cortex of the frontal and parietal lobes of patients with dementia indicates the ineffectiveness of increased cortical blood flow and the resulting shunt blood flow due to the high resistance of the altered small cerebral vessels under high pulsating properties of the main arteries.Conclusion. ASL perfusion is a complementary link to the STRIVE criteria in the diagnosis of chronic cerebrovascular insufficiency. The absence of changes in cerebral perfusion in patients with subjective manifestations of chronic cerebrovascular insufficiency makes it advisable to search for new methods for the diagnosis of preclinical stages of vascular cognitive impairment.

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