Treatment and prognosis of malignant melanoma of the oral cavity: preoperative surgical procedure increases risk of distant metastasis

Primary malignant melanoma of the oral cavity is a rare neoplasm. The tumors tend to metastasize or locally invade tissue more readily than other malignant tumors in the oral region. The survival of patients with mucosal melanomas is less than for those with cutaneous melanomas. Tumor size and metastases are related to the prognosis of the disease. Early detection, therefore, is important.

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Rare Cases in ENT

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2018.v26i2.199 ◽

2018 ◽

Vol 26 (2) ◽

pp. 150-154

Author(s):

Kalyan Pal ◽

Dipanjan Chakraborty ◽

Sohag Kundu ◽

Subrata Mukhopadhyay

Keyword(s):

Squamous Cell Carcinoma ◽

Malignant Melanoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Paranasal Sinuses ◽

Small Proportion ◽

Neck Region ◽

Malignant Neoplasms ◽

Head And Neck Region ◽

Nose And Paranasal Sinuses

In our day to day ENT practice we commonly come across diseases involving the larynx, the oral cavity and the paranasal sinuses. These range from inflammatory disorders to benign and malignant neoplasms. Carcinomas involving the head and neck region are most commonly squamous cell carcinoma. However, a small proportion of cases present with other variants of carcinoma or infective pathology uncommon for the site. In this study we present three rare cases encountered in the out-patient department, namely, Primary Malignant Melanoma of the larynx, Neuroendocrine Tumor of the nose and paranasal sinuses and Rhinosporidiosis of cheek.

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Malignant melanoma of the oral cavity

Indian Journal of Dental Research ◽

10.4103/0970-9290.29882 ◽

2006 ◽

Vol 17 (2) ◽

pp. 94 ◽

Cited By ~ 16

Author(s):

Jagadish Ebenezer

Keyword(s):

Malignant Melanoma ◽

Oral Cavity

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S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in the NOD/SCID/γCnull (NOG) mouse model

Oncology Reports ◽

10.3892/or.14.3.633 ◽

2005 ◽

Author(s):

Norihiro Ikoma ◽

Hitoshi Yamazaki ◽

Yoshiyuki Abe ◽

Yasuhisa Oida ◽

Yasuyuki Ohnishi ◽

...

Keyword(s):

Malignant Melanoma ◽

Mouse Model ◽

Cell Lines ◽

Melanoma Cell ◽

Distant Metastasis ◽

Human Malignant Melanoma ◽

Malignant Melanoma Cell ◽

S100a4 Expression ◽

Melanoma Cell Lines ◽

E Cadherin

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Prognosis after Surgical Excision of Canine Melanomas

Veterinary Pathology ◽

10.1177/030098587901600103 ◽

1979 ◽

Vol 16 (1) ◽

pp. 32-40 ◽

Cited By ~ 88

Author(s):

D. E. Bostock

Keyword(s):

Malignant Melanoma ◽

Oral Cavity ◽

Mitotic Index ◽

Surgical Excision ◽

Skin Lesions ◽

Skin Tumours ◽

Malignant Skin ◽

Index 2 ◽

Eventual Death

One hundred and thirty-four dogs from which melanomas had been excised were studied until death or for at least 2 years after surgery. Seven of 49 (14%) intraoral and lip tumours and 52 of 85 (61%) skin tumours were histologically benign; in spite of this, three of seven (43%) “benign” oral and four of 52 (8%) “benign” skin lesions led to the eventual death of the host. Thirty eight of 42 (90%) dogs with a histologically malignant melanoma of the lip or oral cavity died because of the tumour but only 15 of 33 (45%) with malignant skin melanomas died. Six of 59 (10%) dogs with a tumour of mitotic index 2 or less died from the tumour 2 years after surgery compared to 19 of 26 (73%) dogs having a tumour with a mitotic index of 3 or more.

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An Unusual Presentation of Metastatic Colon Adenocarcinoma in the Oral Cavity

Case Reports in Dentistry ◽

10.1155/2011/357518 ◽

2011 ◽

Vol 2011 ◽

pp. 1-2 ◽

Cited By ~ 2

Author(s):

Abhilash Bhaskaran ◽

Sam Harding ◽

David Courtney

Keyword(s):

Case Report ◽

Colorectal Carcinoma ◽

Oral Cavity ◽

Distant Metastasis ◽

Colon Adenocarcinoma ◽

Unusual Presentation ◽

Differential Diagnoses

Background. A case report of a nonhealing ulcer of the tongue histologically proven to be adenocarcinoma.Method. A 92-year-old man underwent clinical, immunochemistry, and imaging investigation.Results. Tests confirmed a distant metastasis of a primary colorectal carcinoma.Conclusion. Metastasis from colorectal carcinoma to the oral cavity is primarily to bone, but non-healing ulcers of the oral cavity should be considered in differential diagnoses.

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