Prognosis after Surgical Excision of Canine Melanomas

1979 ◽  
Vol 16 (1) ◽  
pp. 32-40 ◽  
Author(s):  
D. E. Bostock
Keyword(s):  
Malignant Melanoma ◽  
Oral Cavity ◽  
Mitotic Index ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Skin Tumours ◽  
Malignant Skin ◽  
Index 2 ◽  
Eventual Death

One hundred and thirty-four dogs from which melanomas had been excised were studied until death or for at least 2 years after surgery. Seven of 49 (14%) intraoral and lip tumours and 52 of 85 (61%) skin tumours were histologically benign; in spite of this, three of seven (43%) “benign” oral and four of 52 (8%) “benign” skin lesions led to the eventual death of the host. Thirty eight of 42 (90%) dogs with a histologically malignant melanoma of the lip or oral cavity died because of the tumour but only 15 of 33 (45%) with malignant skin melanomas died. Six of 59 (10%) dogs with a tumour of mitotic index 2 or less died from the tumour 2 years after surgery compared to 19 of 26 (73%) dogs having a tumour with a mitotic index of 3 or more.

scholarly journals Frequency and Pattern of Malignant Lesions of Skin

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 700-706
Author(s):  
Md Abdur Razzaque ◽  
Avisak Bhattacharjee ◽  
Urmi Bhattacharjee ◽  
Mohammad Asif Ekram Bhuiyan ◽  
Rashidul Hasan ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Malignant Melanoma ◽  
Lower Limb ◽  
Skin Lesions ◽  
P Value ◽  
Age Group ◽  
Elderly Age ◽  
Melanocytic Lesions ◽  
Malignant Skin ◽  
Head Neck

Malignant skin lesions can be widely categorized as melanoma and non-melanoma skin cancer. Skin cancer represents approximately two to four percent of all cancers in Asians. One in every three cancers diagnosed is a skin cancer and one in every five Americans will develop skin cancer in their lifetime.Objective: To determine the frequency and pattern of different malignant skin lesions in our situation.Methods: It was a prospective cross sectional study that was conducted in Surgery, Dermatology, Oncology & Plastic Surgery department of KYAMCH, Sirajgonj from January 2015 to June 2015. Total 60 patients were selected by purposive sampling as a diagnosed case of malignant skin lesion. The data were collected by the active participation of the patients' interviewed by the preformed proforma of data collection sheet and then data were gathered, decorated, tabulated after data cleaning and edition. Then the results were found and they were tested by chi-square test (qualitative data) to see their level of significance i,e p-value which was set as the cut off level at <0.05. So if p-value is >0.05 the results are not significant.Results: The data analysis of 60 patients yielded the following results. Malignant skin lesions were commonly found in the elderly age group (>60yrs) 38.33%. Majority of them had non-melanocytic cancer (56.67%). Mean age of the male respondent was 58.79±6.54 and female respondent was 55.20 6.29 years. Maximum patients were male 66.67%. The male to female ratio was 2:1. According to anatomical site head-neck (52.94%) is the commonest site for non-melanocytic carcinoma whereas lower limb is the commonest site for malignant melanoma (69.23%).Conclusion: Malignant skin lesions were commonly present as melanoma and non-melanocytic carcinoma where man were more affected due to sunlight exposure and non-melanocytic lesions were more than malignant melanoma. Elderly age group are commonly affected. Head-neck is the commonest site for non-melanocytic lesions and lower limb is the commonest site for malignant melanoma. All cases seek initial medical attention commonly in advanced stage.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 700-706

scholarly journals Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Ugur Uslu ◽  
Franz Heppt ◽  
Michael Erdmann
Keyword(s):  
Correct Diagnosis ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Careful Examination ◽  
Acral Lentiginous Melanoma ◽  
Melanoma In Situ ◽  
Malignant Skin ◽  
Rule Out

Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ. Since clinical and dermoscopic examinations did not rule out a malignant skin lesion, surgical excision was performed and confirmed an intracorneal hematoma. In summary, without adequate physical trigger, it may be clinically and dermoscopically challenging to make the correct diagnosis in pigmented palmar and plantar skin alterations. Thus, biopsy or surgical excision of the skin alteration may be necessary to rule out melanoma.

scholarly journals Comparative Review of Malignant Melanoma and Histologically Well-Differentiated Melanocytic Neoplasm in the Oral Cavity of Dogs

2021 ◽  
Vol 8 (11) ◽  
pp. 261
Author(s):  
Won Suk Kim ◽  
Arathi Vinayak ◽  
Barbara Powers
Keyword(s):  
Malignant Melanoma ◽  
Oral Cavity ◽  
Survival Time ◽  
Mitotic Index ◽  
Regional Lymph Node ◽  
High Rate ◽  
Survival Times ◽  
Nuclear Atypia ◽  
Comparative Review ◽  
Well Differentiated

Oral malignant melanoma (OMM) is the most common neoplasm of the canine oral cavity. It is characterized by its aggressive local disease as well as its high rate of lymphatic invasion and distant metastasis. OMM carries a poor prognosis, with most patients succumbing to the disease due to progression of the neoplasm. Histopathologically, OMM is characterized by significant nuclear atypia, a mitotic index of greater than 4/10 hpf, and evidence of vascular invasion or metastasis. Clinically, these lesions can become locally invasive, causing lysis of bones and severe inflammation of the surrounding soft tissue. With time, these lesions can spread to the regional lymph node and to the lungs and other organs. Prognosis can vary depending on the size of the primary tumor, regional node involvement, and distant metastatic disease; however, multiple studies report a relatively short median survival time ranging from less than 4 months to 8 months. Histologically well- differentiated melanocytic neoplasms (HWDMN) are a variant of OMM and sometimes referred to as canine oral melanocytic neoplasms of low malignant potential. Unlike OMM, patients with HWDMN have longer survival times. Histopathologically, HWDMNs have well-differentiated melanocytes with a low mitotic index of 3 or less per 10 hpf and minimal nuclear atypia. HWDMNs have better prognosis with a mean survival time of up to 34 months. This article is a comparative review of OMM and its less aggressive counterpart.

Skin conditions

2011 ◽  
Author(s):  
David Warwick ◽  
Roderick Dunn ◽  
Erman Melikyan ◽  
Jane Vadher
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dupuytren's Disease ◽  
Skin Tumours ◽  
Surgical Incisions ◽  
Malignant Skin ◽  
The Face ◽  
Skin Conditions

Surgical incisions 228Nail 229Benign skin tumours 230Malignant skin tumours 232Squamous cell carcinoma 234Malignant melanoma 236Other malignant skin tumours 240Dupuytren's disease 242The hand is second only to the face in awareness of appearance by both patients and those with whom they interact. Surgeons should always consider this when designing incisions....

Special Considerations In The Management Of Malignant Skin Lesions About The Eye

1993 ◽  
Vol 26 (2) ◽  
pp. 215-230
Author(s):  
Gerry F. Funk ◽  
Henry T. Hoffman ◽  
Keith D. Carter
Keyword(s):  
Skin Lesions ◽  
Malignant Skin

scholarly journals 766. Everything Old is New Again-A Case Series of New World Leishmaniasis in African Children in Portland, Maine

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S428-S428
Author(s):  
Jennifer Jubulis ◽  
Amanda Goddard ◽  
Elizabeth Seiverling ◽  
Marc Kimball ◽  
Carol A McCarthy
Keyword(s):  
Latin America ◽  
Cutaneous Leishmaniasis ◽  
New World ◽  
Pediatric Patients ◽  
Data Extraction ◽  
Clinical Manifestations ◽  
Case Series ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Travel History

Abstract Background Leishmaniasis has many clinical manifestations and treatment regimens, dependent on species and host. Old world leishmaniasis is found primarily in Africa and Asia, and is associated with visceral disease, while new world disease, seen primarily in Latin America, is more commonly mucocutaneous. We present a case series of pediatric African patients with New World cutaneous leishmaniasis (NWCL). Methods Data extraction was performed via chart review, analyzing travel history, clinical presentation, diagnosis, and management in children with cutaneous leishmaniasis presenting to the pediatric infectious diseases clinic in Portland, ME. Biopsy specimens were sent to the federal CDC for identification by PCR and culture. Results Five cases of NWCL were diagnosed in pediatric patients in Maine from November 2018 through February 2020. Median age of patients was 10 years (range 1.5-15 years). Four cases (80%) occurred in children from Angola or Democratic Republic of Congo, arriving in Maine via Central/South America, with one case in a child from Rwanda who arrived in Maine via Texas. Three patients had multiple skin lesions and two had isolated facial lesions. Leishmaniasis was not initially suspected resulting in median time to diagnosis of 5 months (range 1-7 months). Four patients were initially treated with antibacterials for cellulitis and one was treated with griseofulvin. After no improvement, patients underwent biopsy with 2 patients diagnosed with L panamensis, 1 with L braziliensis, 1 with mixed infection (L panamensis and L mexicana), and 1 with Leishmania species only. One patient was managed with surgical excision, 3 with ketoconazole, and 1 was observed off therapy. Four patients were referred to otolaryngology. All continue to be followed in infectious disease clinic. Conclusion We present five cases of new world cutaneous leishmaniasis in African pediatric patients arriving to Maine through Latin America or Texas. Patients were diagnosed with cellulitis, tinea corporis or atopic dermatitis initially, underscoring importance of high index of suspicion in migrant patients. Detailed travel history and epidemiologic knowledge is essential to diagnosis, as patients may present with illness not congruent with country of origin. Optimal therapy remains unclear. Disclosures All Authors: No reported disclosures

Treatment and prognosis of malignant melanoma of the oral cavity: preoperative surgical procedure increases risk of distant metastasis

2008 ◽  
Vol 106 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Masahiro Umeda ◽  
Hideki Komatsubara ◽  
Takashi Shigeta ◽  
Yasutaka Ojima ◽  
Tsutomu Minamikawa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Oral Cavity ◽  
Distant Metastasis ◽  
Surgical Procedure

Pre-malignant skin lesions

Medicine ◽  
2021 ◽  
Author(s):  
Catherine Drislane ◽  
Katie Lacy
Keyword(s):  
Skin Lesions ◽  
Malignant Skin

Common Benign and Malignant Skin Lesions

2001 ◽  
pp. 867-884
Author(s):  
Maryam M. Asgari ◽  
David J. Leffell
Keyword(s):  
Skin Lesions ◽  
Malignant Skin

scholarly journals Primary Oral Malignant Melanoma: Two Case Reports and Review of Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Neeraj Sharma
Keyword(s):  
Malignant Melanoma ◽  
Early Detection ◽  
Oral Cavity ◽  
Tumor Size ◽  
Malignant Tumors ◽  
Case Reports ◽  
Review Of Literature ◽  
Oral Region ◽  
Rare Neoplasm ◽  
Oral Malignant Melanoma

Primary malignant melanoma of the oral cavity is a rare neoplasm. The tumors tend to metastasize or locally invade tissue more readily than other malignant tumors in the oral region. The survival of patients with mucosal melanomas is less than for those with cutaneous melanomas. Tumor size and metastases are related to the prognosis of the disease. Early detection, therefore, is important.

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