Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: A methodological overview of statistical practice in randomized controlled clinical trials

Vaccine ◽  
2007 ◽  
Vol 25 (33) ◽  
pp. 6237-6244 ◽  
Author(s):  
Antje Jahn-Eimermacher ◽  
Jean-Baptist du Prel ◽  
Heinz-Josef Schmitt
1983 ◽  
Vol 92 (6_suppl) ◽  
pp. 32-33
Author(s):  
J. S. Supance ◽  
P. H. Kaleida ◽  
M. L. Casselbrant ◽  
M. M. Blatter ◽  
K. S. Reisinger ◽  
...  

Prevention and safe and effective treatment of otitis media are two of our ultimate research goals. Both of these require that a variety of medical and surgical methods of management be evaluated. The most frequent medical management of otitis media is the administration of antibiotics, decongestants, and antihistamines; therefore, several studies that are either randomized placebo-controlled clinical trials or drug efficacy studies have been undertaken. Also, pharmacokinetic studies either have been performed or are underway to determine the ability of drugs to achieve appropriate blood and middle ear levels. The most common methods of surgical management are myringotomy with or without tympanostomy tube insertion, and adenoidectomy with or without tonsillectomy. Randomized controlled clinical trials are being conducted to determine the efficacy and risk/benefit of these procedures at various stages and levels of severity of otitis media in children. In addition, we are attempting to address the problem of the cost of these methods in relation to their potential benefits.


Healthcare ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 396
Author(s):  
Purificación Cerrato-Carretero ◽  
Raúl Roncero-Martín ◽  
Juan D. Pedrera-Zamorano ◽  
Fidel López-Espuela ◽  
Luis M. Puerto-Parejo ◽  
...  

Preventive actions and potential obesity interventions for children are mainly researched throughout the school period, either as part of the school curricula or after regular school hours, via interventions mostly lasting less than 12 months. We aimed to perform a meta-analysis on randomized controlled clinical trials to evaluate the evidence of the efficacy of long-term school-based interventions in the management of childhood obesity in terms of BMI from a dietary and physical activity-based approach. Eleven randomized controlled clinical trials were examined using the random effects model, and the results showed that there were no significant effects associated with physical activity + nutrition intervention in school children aged 6–12 years, with a pooled standardized mean difference (SMD) (95% CI) of −0.00 (−0.05, 0.04). No effects were observed after subgroup analysis based on the intervention length. The findings from our study indicate that long-term school-based interventions on physical activity and dietary habits received by children aged 6–12 years seem to have no effect on BMI. However, the promotion of such interventions should not be discouraged, as they promote additional positive health outcomes for other domains of children’s health.


2001 ◽  
Vol 153 (4) ◽  
pp. 353-362 ◽  
Author(s):  
Sun Ha Jee ◽  
Jiang He ◽  
Lawrence J. Appel ◽  
Paul K. Whelton ◽  
II Suh ◽  
...  

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