Linearity of eprinomectin pharmacokinetics in lactating dairy sheep following pour-on administration: Excretion in milk and exposure of suckling lambs

2008 ◽  
Vol 154 (1-2) ◽  
pp. 129-136 ◽  
Author(s):  
Lena Hodošček ◽  
Iztok Grabnar ◽  
Luka Milčinski ◽  
Adica Süssinger ◽  
Nevenka Kožuh Eržen ◽  
...  
Keyword(s):  
Dairy Sheep ◽  
Excretion In Milk

Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration

2004 ◽  
Vol 71 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Fernanda Imperiale ◽  
Adrian Lifschitz ◽  
Juan Sallovitz ◽  
Guillermo Virkel ◽  
Carlos Lanusse
Keyword(s):  
Oral Treatment ◽  
Subcutaneous Administration ◽  
Dairy Sheep ◽  
Time Curve ◽  
Administration Routes ◽  
Excretion In Milk ◽  
Concentration Time ◽  
Total Fraction ◽  
Antiparasitic Drugs ◽  
The Relationship

Ivermectin (IVM) and moxidectin (MXD) are broad-spectrum endectocides belonging to the avermectin/milbemycin class of antiparasitic drugs not approved for use in dairy sheep. However, these compounds are widely used extra-label to control endo- and ecto-parasites in lactating dairy sheep. Effects of the route of administration on the pattern of IVM and MXD excretion in milk were comparatively characterized in lactating dairy sheep. The relationship between the milk and plasma disposition kinetics after subcutaneous (s.c.) and oral administration at 200 μg/kg body weight was also evaluated. IVM and MXD concentration profiles were measured in milk and plasma using a specific HPLC-based methodology. IVM and MXD were extensively distributed from the bloodstream to the mammary gland and large quantities, particularly for MXD, were excreted in milk. Residual concentrations of IVM were recovered in milk up to 11 d (oral treatment) or 25 d (s.c. treatment) post treatment. However, high MXD concentrations were detected in milk between 1 h and 35 d after its oral and subcutaneous administration. MXD concentrations as high as 3·77 ng/ml (oral) and 30·3 ng/ml (s.c.) were measured in milk at day 35 post administration. A higher MXD excretion in milk, compared with that of IVM, was obtained for both administration routes. An extensive plasma to milk distribution pattern was observed, being the area under the concentration-time curve of MXD obtained in milk up to 14-fold higher than that measured in the bloodstream. The total fraction of the administered dose excreted in milk for MXD was significantly higher than that for IVM, which agrees with the well known higher MXD lipophilicity. The long persistence of milk residual concentrations of MXD and IVM in lactating dairy sheep should be seriously considered before their extra-label use is recommended.

95 Evaluation of infrared thermography as a diagnostic tool for the detection of foot lesions in dairy sheep

2021 ◽  
Vol 12 (1) ◽  
pp. 74
Author(s):  
Marios Moschovas ◽  
Aphrodite Kalogianni ◽  
Stavros Petrouleas ◽  
Georgios Pavlatos ◽  
Theodoros Pnevmatikos ◽  
...  
Keyword(s):  
Infrared Thermography ◽  
Diagnostic Tool ◽  
Dairy Sheep ◽  
Foot Lesions

scholarly journals Effects of melatonin treatment on milk traits, reproductive performance and immune response in Sarda dairy sheep

2021 ◽  
Vol 20 (1) ◽  
pp. 632-639
Author(s):  
Giovanni Cosso ◽  
Maria Consuelo Mura ◽  
Luisa Pulinas ◽  
Giulio Curone ◽  
Daniele Vigo ◽  
...  
Keyword(s):  
Immune Response ◽  
Reproductive Performance ◽  
Dairy Sheep ◽  
Melatonin Treatment ◽  
Milk Traits

scholarly journals Regenerative rotational grazing management of dairy sheep increases springtime grass production and topsoil carbon storage

2021 ◽  
Vol 125 ◽  
pp. 107484
Author(s):  
Xabier Díaz de Otálora ◽  
Lur Epelde ◽  
Josune Arranz ◽  
Carlos Garbisu ◽  
Roberto Ruiz ◽  
...  
Keyword(s):  
Carbon Storage ◽  
Grazing Management ◽  
Dairy Sheep ◽  
Rotational Grazing ◽  
Grass Production

“Milk-drop syndrome of ewes”: Investigation of the causes in dairy sheep in Greece

2012 ◽  
Vol 106 (1) ◽  
pp. 33-35 ◽  
Author(s):  
N.D. Giadinis ◽  
G. Arsenos ◽  
P. Tsakos ◽  
V. Psychas ◽  
C.I. Dovas ◽  
...  
Keyword(s):  
Dairy Sheep

Disposition of Doramectin Milk Residues in Lactating Dairy Sheep

2003 ◽  
Vol 51 (10) ◽  
pp. 3185-3190 ◽  
Author(s):  
Fernanda A. Imperiale ◽  
Lourdes Mottier ◽  
Juan M. Sallovitz ◽  
Adrián L. Lifschitz ◽  
Carlos E. Lanusse
Keyword(s):  
Dairy Sheep

PRODUCTION POTENTIAL AND BREEDING SCHEMES OF SOME MEDITERRANEAN DAIRY SHEEP BREEDS

1991 ◽  
Vol 8 ◽  
pp. 13-26 ◽  
Author(s):  
N. P. Zervas ◽  
J. Hatziminaoglou ◽  
J. Boyazoglu ◽  
A. Georgoudis
Keyword(s):  
Genetic Parameters ◽  
Management Practices ◽  
Reproductive Potential ◽  
Dairy Sheep ◽  
Phenotypic Characteristics ◽  
Production Potential ◽  
Sheep Population ◽  
Sheep Breeds ◽  
Breeding Schemes ◽  
The Mediterranean

SUMMARYExaminded are some of the most important dairy sheep breeds, among the great diversity of the Mediterranean sheep population, by focusing on their phenotypic characteristics, their productive and reproductive potential as well as on the management practices and systems of testing. Information is also given on their genetic parameters, with emphasis on heritability coefficients, and the range of respective selection and breeding schemes, applied under their particular husbandry conditions.

Effects of supplementation with exhausted myrtle berries on rumen function of dairy sheep

2019 ◽  
Vol 170 ◽  
pp. 51-61 ◽  
Author(s):  
F. Correddu ◽  
F. Fancello ◽  
L. Chessa ◽  
A.S. Atzori ◽  
G. Pulina ◽  
...  
Keyword(s):  
Dairy Sheep

scholarly journals Coxiella burnetii seroprevalence and risk factors in sheep farmers and farm residents in The Netherlands

2013 ◽  
Vol 142 (6) ◽  
pp. 1231-1244 ◽  
Author(s):  
M. M. A. De LANGE ◽  
B. SCHIMMER ◽  
P. VELLEMA ◽  
J. L. A. HAUTVAST ◽  
P. M. SCHNEEBERGER ◽  
...  
Keyword(s):  
Risk Factors ◽  
The Netherlands ◽  
Coxiella Burnetii ◽  
High Frequency ◽  
Significant Risk ◽  
Infection Risk ◽  
Multivariate Logistic Regression ◽  
Dairy Sheep ◽  
Sheep Farm ◽  
Farm Residents

SUMMARYIn this study, Coxiella burnetii seroprevalence was assessed for dairy and non-dairy sheep farm residents in The Netherlands for 2009–2010. Risk factors for seropositivity were identified for non-dairy sheep farm residents. Participants completed farm-based and individual questionnaires. In addition, participants were tested for IgG and IgM C. burnetii antibodies using immunofluorescent assay. Risk factors were identified by univariate, multivariate logistic regression, and multivariate multilevel analyses. In dairy and non-dairy sheep farm residents, seroprevalence was 66·7% and 51·3%, respectively. Significant risk factors were cattle contact, high goat density near the farm, sheep supplied from two provinces, high frequency of refreshing stable bedding, farm started before 1990 and presence of the Blessumer breed. Most risk factors indicate current or past goat and cattle exposure, with limited factors involving sheep. Subtyping human, cattle, goat, and sheep C. burnetii strains might elucidate their role in the infection risk of sheep farm residents.

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