Coxiella burnetii seroprevalence and risk factors in sheep farmers and farm residents in The Netherlands

SUMMARYIn this study, Coxiella burnetii seroprevalence was assessed for dairy and non-dairy sheep farm residents in The Netherlands for 2009–2010. Risk factors for seropositivity were identified for non-dairy sheep farm residents. Participants completed farm-based and individual questionnaires. In addition, participants were tested for IgG and IgM C. burnetii antibodies using immunofluorescent assay. Risk factors were identified by univariate, multivariate logistic regression, and multivariate multilevel analyses. In dairy and non-dairy sheep farm residents, seroprevalence was 66·7% and 51·3%, respectively. Significant risk factors were cattle contact, high goat density near the farm, sheep supplied from two provinces, high frequency of refreshing stable bedding, farm started before 1990 and presence of the Blessumer breed. Most risk factors indicate current or past goat and cattle exposure, with limited factors involving sheep. Subtyping human, cattle, goat, and sheep C. burnetii strains might elucidate their role in the infection risk of sheep farm residents.

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Risk factors for intensive care admission in children with severe acute asthma in the Netherlands: a prospective multicentre study

ERJ Open Research ◽

10.1183/23120541.00126-2020 ◽

2020 ◽

Vol 6 (3) ◽

pp. 00126-2020 ◽

Cited By ~ 1

Author(s):

Shelley A. Boeschoten ◽

Annemie L. Boehmer ◽

Peter J. Merkus ◽

Joost van Rosmalen ◽

Johan C. de Jongste ◽

...

Keyword(s):

Risk Factors ◽

Intensive Care ◽

The Netherlands ◽

Multicentre Study ◽

Tobacco Smoke ◽

Acute Asthma ◽

Significant Risk ◽

General Ward ◽

Tobacco Smoke Exposure ◽

Severe Acute Asthma

RationaleSevere acute asthma (SAA) can be fatal, but is often preventable. We previously observed in a retrospective cohort study, a three-fold increase in SAA paediatric intensive care (PICU) admissions between 2003 and 2013 in the Netherlands, with a significant increase during those years of numbers of children without treatment of inhaled corticosteroids (ICS).ObjectivesTo determine whether steroid-naïve children are at higher risk of PICU admission among those hospitalised for SAA. Furthermore, we included the secondary risk factors tobacco smoke exposure, allergic sensitisation, previous admissions and viral infections.MethodsA prospective, nationwide multicentre study of children with SAA (2–18 years) admitted to all Dutch PICUs and four general wards between 2016 and 2018. Potential risk factors for PICU admission were assessed using logistic regression analyses.Measurements and main results110 PICU and 111 general ward patients were included. The proportion of steroid-naïve children did not differ significantly between PICU and ward patients. PICU children were significantly older and more exposed to tobacco smoke, with symptoms >1 week prior to admission. Viral susceptibility was not a significant risk factor for PICU admission.ConclusionsChildren with SAA admitted to a PICU were comparable to those admitted to a general ward with respect to ICS treatment prior to admission. Preventable risk factors for PICU admission were >7 days of symptoms without adjustment of therapy and exposure to tobacco smoke. Physicians who treat children with asthma must be aware of these risk factors.

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Risk factors associated with stillbirth of piglets born from oxytocin-assisted parturitions

Veterinary World ◽

10.14202/vetworld.2020.2172-2177 ◽

2020 ◽

Vol 13 (10) ◽

pp. 2172-2177

Author(s):

Nguyen Hoai Nam ◽

Peerapol Sukon

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Models ◽

Significant Risk ◽

Gestation Length ◽

Stillbirth Rate ◽

Multivariate Logistic Regression ◽

Crown Rump Length ◽

Logistic Regression Models ◽

Factors Associated

Aim: The present study aimed to investigate the effects of different risk factors on stillbirth of piglets born from oxytocin-assisted parturitions. Materials and Methods: Data were collected from a total of 1121 piglets born from 74 Landrace x Yorkshire crossbred sows from a herd. Logistic regression models were used to determine the associations between stillbirth and different risk factors including parity (1, 2, 3-5, and 6-10), gestation length (GL) (112-113, 114-116, and 117-119 days), litter size, birth order (BO), sex, birth interval (BI), cumulative farrowing duration, birth weight (BW), crown rump length, BW deviation, body mass index, ponderal index (PI), and the use of oxytocin during expulsive stage of farrowing. Results: The incidence of stillbirth at litter level and stillbirth rate was 59.5% (44/74) and 8.1% (89/1094), respectively. The final multivariate logistic regression selected BO, BI, PI, GL, and parity as the five most significant risk factors for stillbirth. Increased BO and BI, GL <114 and >116 days, parity 6-10, and low PI increased the stillbirth rate in piglets. Conclusion: Several factors previously determined as risks for stillbirth in exogenous oxytocin-free parturitions also existed in exogenous oxytocin-assisted parturitions. One dose of oxytocin at fairly high BO did not increase stillbirth, whereas two doses of oxytocin were potentially associated with increased values.

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Postoperative facial palsy after pediatric posterior fossa tumor resection

Journal of Neurosurgery Pediatrics ◽

10.3171/2020.9.peds20372 ◽

2021 ◽

pp. 1-6

Author(s):

Jason K. Chu ◽

Peter A. Chiarelli ◽

Nolan D. Rea ◽

Norianne Pimentel ◽

Benjamin E. Flyer ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Posterior Fossa ◽

Facial Palsy ◽

Tumor Resection ◽

Significant Risk ◽

Posterior Fossa Tumor ◽

Facial Weakness ◽

Multivariate Logistic Regression ◽

Study Results

OBJECTIVE Facial palsy can be caused by masses within the posterior fossa and is a known risk of surgery for tumor resection. Although well documented in the adult literature, postoperative facial weakness after posterior fossa tumor resection in pediatric patients has not been well studied. The objective of this work was to determine the incidence of postoperative facial palsy after tumor surgery, and to investigate clinical and radiographic risk factors. METHODS A retrospective analysis was conducted at a single large pediatric hospital. Clinical, radiographic, and histological data were examined in children who were surgically treated for posterior fossa tumors between May 1, 1994, and June 1, 2011. The incidence of postoperative facial weakness was documented. A multivariate logistic regression model was used to analyze the predictive ability of clinicoradiological variables for facial weakness. RESULTS A total of 163 patients were included in this study. The average age at surgery was 7.4 ± 4.7 years, and tumor pathologies included astrocytoma (44%), medulloblastoma (36%), and ependymoma (20%). The lesions of 27 patients (17%) were considered high grade in nature. Thirteen patients (8%) exhibited preoperative symptoms of facial palsy. The overall incidence of postoperative facial palsy was 26% (43 patients), and the incidence of new postoperative facial palsy in patients without preoperative facial weakness was 20% (30 patients). The presence of a preoperative facial palsy had a large and significant effect in univariate analysis (OR 11.82, 95% CI 3.07–45.44, p < 0.01). Multivariate logistic regression identified recurrent operation (OR 4.45, 95% CI 1.49–13.30, p = 0.01) and other preoperative cranial nerve palsy (CNP; OR 3.01, 95% CI 1.24–7.29, p = 0.02) as significant risk factors for postoperative facial weakness. CONCLUSIONS Facial palsy is a risk during surgical resection of posterior fossa brain tumors in the pediatric population. The study results suggest that the incidence of new postoperative facial palsy can be as high as 20%. The presence of preoperative facial palsy, an operation for recurrent tumor, and the presence of other preoperative CNPs were found to be significant risk factors for postoperative facial weakness.

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Future options to reduce RhD immunization in addition to a high coverage prevention program of antenatal and postnatal RhIg: a nationwide cohort study

10.22541/au.162689910.05228720/v1 ◽

2021 ◽

Author(s):

Yolentha Slootweg ◽

Carolien Zwiers ◽

Johanna Koelewijn ◽

Ellen van der Schoot ◽

Dick Oepkes ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

The Netherlands ◽

Perinatal Death ◽

Significant Risk ◽

Surgical Removal ◽

Additional Risk Factor ◽

Miscarriage Rate ◽

High Coverage ◽

Surgical Interventions

Objective: To evaluate which risk factors for RhD immunization remain, despite adequate routine antenatal and postnatal RhIg prophylaxis (1000 IU RhIg) and additional administration of RhIg. Assessment of the prevalence of RhD immunizations. Design: Prospective cohort Setting: The Netherlands. Population: Two-year nationwide cohort. Methods: RhD-negative women in their first RhD immunized pregnancy and their foregoing non-immunized pregnancy. Risk factors for RhD immunization were compared with population data. Main outcomes measures: Risk factors for FMH and subsequently RhD immunization, prevalence of RhD immunizations. Results: The prevalence of newly detected RhD immunizations was 0.31% (79/25,170) of all RhD-negative pregnant women in the Netherlands. After exclusion, 193 women remained. Significant risk factors found in the group of 113 parous women (previous pregnancy >16 weeks, RhD positive child) were; caesarean section (CS) (OR 1.7, 95% CI 1.1-2.6), perinatal death (OR 3.5, 95% CI 1.1-10.9), gestational age over 42 weeks (OR 6.1, 95% CI 2.2-16.6), postnatal bleeding (>1000mL) (OR 2.0 95% CI 1.1-3.6), surgical removal of the placenta (SRP) (OR 4.3, 95% CI 2.0-9.3). The miscarriage rate in the group of women without a previous RhD positive child was significantly higher than in the Dutch population (35% vs 12.5% p<0.001). Conclusion: Complicated deliveries, including cases of major bleeding and surgical interventions (CS, SRP) need to be recognized as risk factor, requiring determination of FMH volume and adjustment of RhIg dosing. Miscarriage may be an additional risk factor for RhD immunization, requiring further studies. Funding: This research was partly funded by a grant from Sanquin Amsterdam.

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Maternal haemoglobin and premature child delivery

Eastern Mediterranean Health Journal ◽

10.26719/1998.4.3.480 ◽

1998 ◽

Vol 4 (3) ◽

pp. 480-486

Author(s):

M. Arafa ◽

H. Abou Zied ◽

A. F. Attia ◽

M. Youssof

Keyword(s):

Risk Factors ◽

Significant Risk ◽

Multivariate Logistic Regression Analysis ◽

Predictive Equation ◽

Multivariate Logistic Regression ◽

Third Trimester ◽

Preterm Baby ◽

The Third ◽

Premature Child ◽

In Pregnancy

The effect of anaemia [haemoglobin <11 g/dl] during pregnancy on preterm delivery was prospectively studied in 921 low-risk pregnancies. The association between anaemia and prematurity was measured at three different haemoglobin levels, early in pregnancy and during the third trimester. The risk of prematurity was higher with haemoglobin <9 g/dl in early pregnancy, followed by haemoglobin <10 g/dl during the same period;the least risk was recorded during the third trimester when haemoglobin was <10 g/dl. In multivariate logistic regression analysis, haemoglobin was the most important predictor of prematurity after controlling for other confounders. When applying the logistic predictive equation, a woman with all the significant risk factors included in the multivariate analysis had a 72% probability of giving birth to a preterm baby

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Human-to-human transmission of avian influenza A/H7N7, The Netherlands, 2003

Eurosurveillance ◽

10.2807/esm.10.12.00584-en ◽

2005 ◽

Vol 10 (12) ◽

pp. 3-4 ◽

Cited By ~ 28

Author(s):

M Du Ry van Beest Holle ◽

A Meijer ◽

M Koopmans ◽

C M de Jager

Keyword(s):

Risk Factors ◽

The Netherlands ◽

Avian Influenza ◽

Influenza A ◽

Univariate Analysis ◽

Significant Risk ◽

Stable Model ◽

Serum Samples ◽

Poultry Workers ◽

Household Members

An outbreak of highly pathogenic avian influenza A virus subtype H7N7 began in poultry farms in the Netherlands in 2003. Virus infection was detected by RT-PCR in 86 poultry workers and three household contacts of PCR-positive poultry workers, mainly associated with conjunctivitis. To determine the magnitude of and risk factors for human-to-human transmission of influenza A/H7N7 in the Netherlands, a retrospective cohort study among household members of infected poultry workers was undertaken. In total, 33 (58.9%) of 56 (among 62) participants who provided blood samples had positive H7 serology, using single convalescent serum samples obtained at least 3 weeks after onset of symptoms of the index case. Eight household members (12.9%) reported symptoms (conjunctivitis and/or ILI), of which four of five (80.0%) tested seropositive. On univariate analysis, significant risk factors for seropositivity included having at least two toilets, a pet bird, and using cloth handkerchiefs. It was not possible to obtain a stable model for binomial regression for the outcome of A/H7N7 infection. Further seroprevalence studies among contacts of asymptomatic H7 cases should be conducted.

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Incidence and Risk Factors for Severe Thrombocytopenia in Lymphoma Patients Receiving Chemotherapy.

Blood ◽

10.1182/blood.v108.11.3994.3994 ◽

2006 ◽

Vol 108 (11) ◽

pp. 3994-3994

Author(s):

Auris Huen ◽

Xiao Zhou ◽

Shyam Teegala ◽

Yuan Ji ◽

Luis Fayad ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Medical Records ◽

Cell Lymphoma ◽

Significant Risk ◽

Severe Thrombocytopenia ◽

Multivariate Logistic Regression ◽

Prior Therapy ◽

Burkitts Lymphoma ◽

Grade 3

Abstract Background: Severe thrombocytopenia (TCP) can be a serious complication of chemotherapy (CT) in lymphoma patients (pts), however the exact incidence with the current regimens and risk factors for TCP are not well known. Methods: A retrospective cohort study was conducted to determine the incidence of TCP, and logistic regression analysis were performed to identify the clinical and laboratory features correlated with severe TCP in lymphoma. Medical records of 538 consecutive pts out of the 1050 lymphoma pts, who were newly referred to MDACC in 2003, were reviewed. Results: 202 pts who received > 1 cycle of treatment were included in the analysis. The total number of CT cycles (with PLT counts) for the 202 pts was 985 (median 6, range, 1–20). Grade (gr) 4 TCP (PLT nadir < 25x103/μL) was observed in 39% (79/202) of pts and 20% (196/985) of cycles. The median cycle in which gr 4 TCP occurred was 2 (range, 1 to 11), and median PLT nadir count for gr 4 TCP was 12x103/μL (3 to 24x103/μL). The regimens most commonly associated with gr 4 TCP were Hyper-CVAD/ Ara-c/Mtx (31/35=89%), ESHAP (6/7=86%), ASHAP (3/4=75%), and ICE (5/7=71%) + rituxan, and the most common histological subtypes were MCL (15/19=79%), Burkitts lymphoma (7/9=78%), T cell lymphoma (10/17=58%), and LCL (31/64=48%). Thirty two of 79 (41%) gr 4 TCP pts had bleeding as compared to 8 of 123 (7%) pts with higher PLT counts (p=0.0001). Overall, the incidence of bleeding was 20% (40/202) by pts and 6% (60/985) by cycles; however, the most incidents [95% (57/60)] were minor. 80% (63/79) of Grade 4 TCP pts received PLT transfusions, as compared to only 2% (2/123) of the rest (p<0.0001). Using multivariate logistic regression, histological gr, (highly aggressive or aggressive vs indolent: OR=10.402, 95% CI, 3.991 to 27.107, p<0.0001), baseline PLT count (≤150 vs >150x103/μL: OR=4.610, 95% CI, 1.366 to 15.560, p=0.0138), prior therapy (yes vs. no: OR=2.575, 95% CI, 1.337 to 4.961, p=0.0047), Beta2 Microglobulin (B2M) (≥2 vs <2mg/L: OR=2.846, 95% CI, 1.401 to 5.783, p=0.0038), age (>60 vs. ≤60 yrs: OR=0.479, 95% CI, 0.241 to 0.952, p=0.0356) were the most important risk factors for grade 3 or 4 TCP. Conclusions: The incidence of severe TCP in this population is high. Baseline pt characteristics including histological gr, PLT counts, prior therapy, age and serum B2M were found to be significant risk factors predictive for chemotherapy-induced TCP (CIT). These findings could be useful to identify high risk pts for consideration of treatment approaches for prevention and treatment of CIT.

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Coxiella Burnetii in Horses of Algeria: Seroprevalence and Associated Risk Factors

World s Veterinary Journal ◽

10.54203/scil.2020.wvj72 ◽

2020 ◽

Vol 10 (4) ◽

pp. 602-608

Author(s):

Samir Ansel ◽

Karima Benfodil ◽

Abdellah Mohamed Cherif ◽

Amine Abdelli ◽

Rachid Kaidi ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Coxiella Burnetii ◽

Q Fever ◽

Univariate Analysis ◽

Small Ruminants ◽

Water Source ◽

Enzyme Linked Immunosorbent Assay ◽

Multivariate Logistic Regression ◽

Prophylactic Measures

The Q fever is a worldwide zoonotic disease caused by Coxiella burnetii (an obligate intracellular bacterium). This pathogen affects humans, ruminants, equines, carnivores, rodents, and birds. A cross-sectional study was carried out from March 2017 to May 2018 to assess the seroprevalence and identify the risk factors of C. burnetii infection in horses (Equus Caballus) residing in three districts of Algerian, namely Tiaret, El-Bayadh, and Ghardaia. Serum samples collected from 182 horses were analyzed via enzyme-linked immunosorbent assay (ELISA). Association of seropositivity with potential risk factors related to animals (e.g., age, gender, breed, housing, and presence of ticks), breeding characteristics (e.g., geographical localization, contact with animals), and environmental characteristics (i.e., presence of water source) was analyzed by univariate and multivariate logistic regression. An overall seroprevalence of 9.9% (18/182) was obtained. The univariate analysis of risk factors for C. burnetii seroprevalence demonstrated higher seropositivity in horses that had contact with small ruminants (p=0.004) and dromedaries (p=0.002) as well as in those living near a water source (p=0.036) and in El-Bayadh district (p=0.005). The multivariate logistic regression analysis indicated that the risk of C. burnetii infection was significantly higher in horses that were in contact with small ruminants (RR: 15.6). Algeria is endemic for Q fever in horses and prophylactic measures must be taken to reduce /prevent its transmission to animals and humans.

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Clinical characteristics of lameness and potential risk factors in intensive and semi-intensive dairy sheep flocks in Greece

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.15485 ◽

2017 ◽

Vol 64 (2) ◽

pp. 123 ◽

Cited By ~ 8

Author(s):

A. I. GELASAKIS (Α.Ι. ΓΕΛΑΣΑΚΗΣ) ◽

G. OIKONOMOU (Γ. ΟΙΚΟΝΟΜΟΥ) ◽

R. C. BICALHO ◽

G. E. VALERGAKIS (Γ.Ε. ΒΑΛΕΡΓΑΚΗΣ) ◽

G. S. FTHENAKIS (Γ.Χ. ΦΘΕΝΑΚΗΣ) ◽

...

Keyword(s):

Risk Factors ◽

Significant Risk ◽

Stocking Density ◽

Farm Size ◽

Foot Rot ◽

Dairy Sheep ◽

White Line ◽

Logistic Regression Models ◽

Potential Risk Factors ◽

Epidemiological Characteristics

Objectives of the study were to present descriptive epidemiological characteristics of lameness in intensively and semi-intensively reared flocks of Chios-breed dairy sheep in Greece, as well as to identify potential factors that may affect development, severity and duration of the disorder. In total, 1618 ewes in nine flocks were used for assessment of locomotion score and detailed clinical examination, which were performed fortnightly throughout a milking period. Subsequently, two logistic regression models were employed to assess impact of various variables on occurrence and severity of lameness. Mean lameness incidence in the nine flocks under surveillance during the milking period was 6.8% (110 cases in 1618 ewes); between flocks range of the incidence was 0.4%-22.0%. In 48% of the cases, lameness was considered to be severe. Foot-rot was found to be the commonest lameness-causing disorder, accounting for 66% of all cases. During the investigation, incidence of lameness in relation to the causing factor was 4.5% for foot-rot, 1% for white line abscesses, 1% for white line disease, <0.5% for pedal joint abscesses and <0.5% for hoof injuries. Farm size, stocking density, parity of the ewes and lambing season were identified as significant risk factors for dairy sheep lameness occurrence. Finally, stocking density was also found to affect lameness severity.

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Somatogenic depression in childhood and adolescence

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) ◽

10.33920/med-01-2011-04 ◽

2020 ◽

pp. 29-35

Author(s):

Yu. F. Antropov

Keyword(s):

Risk Factors ◽

Children And Adolescents ◽

Statistical Methods ◽

Clinical Features ◽

High Frequency ◽

Therapeutic Approach ◽

Depressive Disorders ◽

Significant Risk ◽

Childhood And Adolescence ◽

Somatic Disorders

The problem of somatogenic depressive disorders in childhood and adolescence remains urgent due to the high frequency and pronounced maladaptive effects. The purpose of the work was to clarify pathogenesis factors, frequency and clinical features of somatogenic affective (depressive) disorders in children and adolescents. 268 patients aged 1 to 17 years were studied using clinical-psychopathological, clinical-psychological and statistical methods. A high frequency (16,8 %) of somatogenic depression in the psychosomatic contingent, pathogenetically significant risk factors, as well as clinical features of somatogenic depressive disorders, were established. A certain association of somatogenic depressive and somatic disorders is emphasized, which makes it possible to substantiate a pathogenetically directed therapeutic approach.

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