Acute phase proteins, interleukin-6, tumor necrosis factor, nitric oxide and oxidative stress markers in horses with cutaneous habronemosis under field condition

2018 ◽  
Vol 255 ◽  
pp. 20-25 ◽  
Author(s):  
W. El-Deeb ◽  
O. Iacob ◽  
M. Fayez ◽  
M. Elgioushy ◽  
T. Shawaf ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Tumor Necrosis Factor ◽  
Field Condition ◽  
Tumor Necrosis ◽  
Acute Phase Proteins ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress ◽  
Necrosis Factor

scholarly journals Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects

2018 ◽  
Author(s):  
Andreza De Paula Santos Epifânio ◽  
Karla Pereira Balbino ◽  
Monica De Paula Jorge ◽  
Sonia M.R Ribeiro ◽  
Ana Vládia Bandeira Moreira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals A Nonpolar Blueberry Fraction Blunts NADPH Oxidase Activation in Neuronal Cells Exposed to Tumor Necrosis Factor-α

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Sally J. Gustafson ◽  
Kriya L. Dunlap ◽  
Colin M. McGill ◽  
Thomas B. Kuhn
Keyword(s):  
Oxidative Stress ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Neuronal Degeneration ◽  
Neuroblastoma Cells ◽  
Necrosis Factor Alpha ◽  
Human Neuroblastoma ◽  
Production Characteristic ◽  
And Oxidative Stress ◽  
Necrosis Factor

Inflammation and oxidative stress are key to the progressive neuronal degeneration common to chronic pathologies, traumatic injuries, and aging processes in the CNS. The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) orchestrates cellular stress by stimulating the production and release of neurotoxic mediators including reactive oxygen species (ROS). NADPH oxidases (NOX), ubiquitously expressed in all cells, have recently emerged as pivotal ROS sources in aging and disease. We demonstrated the presence of potent NOX inhibitors in wild Alaska bog blueberries partitioning discretely into a nonpolar fraction with minimal antioxidant capacity and largely devoid of polyphenols. Incubation of SH-SY5Y human neuroblastoma cells with nonpolar blueberry fractions obstructed the coalescing of lipid rafts into large domains disrupting NOX assembly therein and abolishing ROS production characteristic for TNF-αexposure. These findings illuminate nutrition-derived lipid raft modulation as a novel therapeutic approach to blunt inflammatory and oxidative stress in the aging or diseased CNS.

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