Antigens and their diagnostic performance for Canine Visceral Leishmaniasis: a critical review

2021 ◽  
pp. 109638
Author(s):  
Raissa Barbosa de Castro ◽  
João Victor Badaró de Moraes ◽  
Gustavo Costa Bressan ◽  
Raphael de Souza Vasconcellos ◽  
Abelardo Silva-Júnior ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Critical Review ◽  
Diagnostic Performance ◽  
Canine Visceral Leishmaniasis

scholarly journals Leishmaniose visceral canina no RS: revisão crítica / Canine visceral leishmaniasis in RS: critical review

2021 ◽  
Vol 7 (12) ◽  
pp. 111444-111452
Author(s):  
Gabriela De Carvalho Jardim ◽  
Tábata Pereira Dias ◽  
Helena Piúma Gonçalves ◽  
Nielle Versteg ◽  
Laura Dias Petricione de Souza ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Critical Review ◽  
Canine Visceral Leishmaniasis

scholarly journals Phase II validation study of the rK39 ELISA prototype for the diagnosis of canine visceral leishmaniasis in Brazil

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Fernanda Alvarenga Cardoso Medeiros ◽  
Job Alves de Souza Filho ◽  
José Ronaldo Barbosa ◽  
Lucas Edel Donato ◽  
Fabiano Borges Figueiredo ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Validation Study ◽  
Diagnostic Performance ◽  
Clinical Status ◽  
Control Measures ◽  
Canine Visceral Leishmaniasis ◽  
Reference Standard ◽  
Serum Samples ◽  
Transmission Cycle ◽  
Healthy Dogs

Abstract: Dogs are the main reservoirs in the domestic transmission cycle of visceral leishmaniasis, and the diagnosis is essential for the effectiveness of the control measures recommended by the Brazilian Ministry of Health. We assessed the diagnostic performance of the ELISA-Vetlisa/BIOCLIN prototype with serum samples from 200 dogs, in triplicate, including symptomatic, oligosymptomatic, asymptomatic, and healthy dogs, originated by two distinct panels (A and B) characterized by parasitological tests as the reference standard. In this study, the prototype kit showed a 99% sensitivity (95%CI: 94.5-100.0) and a 100% specificity (95%CI: 96.4-100.0). The sensitivity of the prototype kit did not vary significantly with the clinical status of the dogs. Considering the final result classification (positive or negative), agreement between the results of repeated tests was almost perfect (kappa = 0.99; 95%CI: 0.98-1.00). ELISA-Vetlisa/BIOCLIN is a promising option for the serological diagnosis of canine visceral leishmaniasis in Brazil.

Diagnostic and prognostic potential of antibodies against O-acetylated sialic acids in canine visceral leishmaniasis

1999 ◽  
Vol 70 (1-2) ◽  
pp. 55-65 ◽  
Author(s):  
Mitali Chatterjee ◽  
Gad Baneth ◽  
Charles L Jaffe ◽  
Vineeta Sharma ◽  
Chitra Mandal
Keyword(s):  
Visceral Leishmaniasis ◽  
Sialic Acids ◽  
Canine Visceral Leishmaniasis

scholarly journals Evaluation of a new set of recombinant antigens for the serological diagnosis of human and canine visceral leishmaniasis

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184867 ◽  
Author(s):  
Franklin B. Magalhães ◽  
Artur L. Castro Neto ◽  
Marilia B. Nascimento ◽  
Wagner J. T. Santos ◽  
Zulma M. Medeiros ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Serological Diagnosis ◽  
Canine Visceral Leishmaniasis ◽  
Recombinant Antigens

scholarly journals Comparison between ELISA using total antigen and immunochromatography with antigen rK39 in the diagnosis of canine visceral leishmaniasis

2010 ◽  
Vol 173 (3-4) ◽  
pp. 330-333 ◽  
Author(s):  
Valéria Marçal Félix de Lima ◽  
Karina Reinaldo Fattori ◽  
Aparecida de Fátima Michelin ◽  
Luiz da Silveira Neto ◽  
Rosemere de O. Vasconcelos
Keyword(s):  
Visceral Leishmaniasis ◽  
Canine Visceral Leishmaniasis

scholarly journals Canine visceral leishmaniasis follow-up: a new anti-IgG serological test more sensitive than ITS-1 conventional PCR

2017 ◽  
Vol 248 ◽  
pp. 62-67 ◽  
Author(s):  
Angélica Rosa Faria ◽  
Simone da Fonseca Pires ◽  
Alexandre Barbosa Reis ◽  
Wendel Coura-Vital ◽  
Júlia Angélica Gonçalves da Silveira ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Serological Test ◽  
Canine Visceral Leishmaniasis ◽  
Conventional Pcr

scholarly journals Validation of the Dual-path Platform chromatographic immunoassay (DPP® CVL rapid test) for the serodiagnosis of canine visceral leishmaniasis

2018 ◽  
Vol 113 (11) ◽  
Author(s):  
Fabiano Borges Figueiredo ◽  
Tassia Cristina Bello de Vasconcelos ◽  
Maria de Fátima Madeira ◽  
Rodrigo Caldas Menezes ◽  
Ana Nilce Silveira Maia-Elkhoury ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Rapid Test ◽  
Canine Visceral Leishmaniasis

scholarly journals First autochthonous case of canine visceral leishmaniasis in Volta Redonda, Rio de Janeiro, Brazil

2013 ◽  
Vol 22 (3) ◽  
pp. 424-426 ◽  
Author(s):  
Monique Paiva de Campos ◽  
Denise Amaro da Silva ◽  
Maria de Fátima Madeira ◽  
Artur Augusto Mendes Velho Júnior ◽  
Fabiano Borges Figueiredo
Keyword(s):  
Visceral Leishmaniasis ◽  
Diagnostic Tests ◽  
Rio De Janeiro ◽  
Scientific Community ◽  
Clinical Manifestations ◽  
Canine Visceral Leishmaniasis ◽  
Leishmania Chagasi ◽  
Laboratory Findings ◽  
Autochthonous Case ◽  
Canine Diseases

In Brazil, American visceral leishmaniasis (AVL) is caused byLeishmania (Leishmania) chagasi and its main vector isLutzomyia longipalpis. Cases of canine visceral leishmaniasis (CVL) in non-endemic areas have been reported over the last few years throughout the country. The objective of this research note is to describe an autochthonous case of CVL that occurred in the municipality of Volta Redonda, state of Rio de Janeiro, an area where the disease is not endemic, alerting veterinarians and the scientific community to the expansion of this important zoonosis and advising veterinary practitioners on how to deal with a suspicion of CVL. Canine visceral leishmaniasis can be misdiagnosed within a broad spectrum of canine diseases based on clinical and laboratory findings. Therefore, knowledge of its clinical manifestations, specific and sensitive laboratory diagnostic tests and parasitological procedures are of the utmost importance for rapid confirmation and notification of a case, thus contributing directly to the control of a focus.

scholarly journals High accuracy of an ELISA test based in a flagella antigen of Leishmania in serodiagnosis of canine visceral leishmaniasis with potential to improve the control measures in Brazil – A Phase II study

2018 ◽  
Vol 12 (10) ◽  
pp. e0006871 ◽  
Author(s):  
Lairton Souza Borja ◽  
Lívia Brito Coelho ◽  
Matheus Silva de Jesus ◽  
Artur Trancoso Lopo de Queiroz ◽  
Paola Alejandra Fiorani Celedon ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Phase Ii ◽  
Phase Ii Study ◽  
High Accuracy ◽  
Elisa Test ◽  
Control Measures ◽  
Canine Visceral Leishmaniasis

scholarly journals Can vaccines against canine visceral leishmaniasis interfere with the serological diagnostics recommended by the Brazilian Ministry of Health?

2017 ◽  
Vol 47 (4) ◽  
Author(s):  
Monique Paiva de Campos ◽  
Paula Mello De Luca ◽  
Alinne Rangel dos Santos Renzetti ◽  
Sara Maria Marques de Souza ◽  
Artur Augusto Velho Mendes Júnior ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Enzyme Immunoassay ◽  
Clinical Evaluation ◽  
Laboratory Tests ◽  
Endemic Area ◽  
Canine Visceral Leishmaniasis ◽  
Ministry Of Health ◽  
Evaluation Time ◽  
One Year ◽  
Serological Diagnostics

ABSTRACT: The objective of the current research was to assess seroconversion in dogs immunized with Leishmune® and Leish Tec® vaccines using rapid chromatographic immunoassay DPP® (Dual Path Platform) (DPP CVL) and enzyme immunoassay (EIE) up to one year after the vaccination protocol. The study sample comprised 28 dogs divided into two groups, each group immunized with an anti-CVL vaccine and clinically monitored for one year through clinical evaluation and laboratory tests. 22 (78.5%) dog were monitored. During the evaluation time (T1-30 days, T2-6 months, and T3-1 year after vaccination) the results for all dogs were negative for CVL, except for one animal vaccinated with Leish tec® that seroconverted in the DPP CVL test at T2. Subsequent examinations of this dog were negative. Our results showed that in a non-endemic area, even at different evaluation times, dogs vaccinated against CVL with Leishmune® or Leish tec® did not seroconvert in the serological protocol used by the Brazilian Ministry of Health (DPP/EIE).

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