Prognostic Value of Early S100 Calcium Binding Protein B and Neuron-Specific Enolase in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage: A Pilot Study

Purpose: Foot-strike patterns (FSP) in running are related to certain impact kinetics during ground contact. A rear-foot strike (RFS) has been associated with higher impact forces, whereas a forefoot strike (FFS) is assumed to minimize these impact forces. This study investigated the effects of running with RFS or FFS on impact-sensitive neuronal biomarkers S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and lactate dehydrogenase (LDH). Methods: In this randomized crossover study, 18 healthy recreational runners (14 male, mean [SD] age 28.2 [4.7] y, body mass index 22.8 [1.9]) ran 2 separate 5-mile runs with RFS or FFS, respectively. Blood samples were taken before (pre), 30 min after (post 0), and 24 h after (post 24) the run. S100B, NSE, and LDH concentrations were determined and analyzed (3 × 2 data model). Results: S100B, NSE, and LDH concentrations increased from pre to post 0 and decreased within 24 h back to the baseline level, demonstrating a significant time effect (all P < .01, all ). No main effect for FSP or any significant interaction effect indicating FSP-specific differences between FFS or RFS was found (all P > .05, all ), except for LDH (P < .001, ). Conclusions: NSE, S100B, and LDH concentration increased in the short term after running and returned to normal in 24 h. FSP with varying impact forces does not influence the increase of these biomarkers. LDH findings favor peripheral origins, but mixed effects are possible. Thus, further research is needed to estimate the risk of mild traumatic encephalopathy.

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Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhage

Medicine ◽

10.1097/01.md.0000476046.44577.d5 ◽

2015 ◽

Vol 94 (50) ◽

pp. 1 ◽

Cited By ~ 1

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Intracranial Hemorrhage ◽

Calcium Binding ◽

Heat Shock Protein 70 ◽

Binding Protein ◽

Neuron Specific Enolase ◽

Calcium Binding Protein ◽

S100 Calcium Binding Protein ◽

Protein B

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Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis

Journal of Clinical Research in Pediatric Endocrinology ◽

10.4274/jcrpe.galenos.2019.2018.0280 ◽

2019 ◽

Vol 11 (4) ◽

pp. 374-387 ◽

Cited By ~ 1

Author(s):

Hatem Hamed Elshorbagy ◽

Naglaa Fathy Barseem ◽

Akram Elshafey Elsadek ◽

Ashraf Hamed Al-shokary ◽

Yehia Hamed Abdel Maksoud ◽

...

Keyword(s):

Diabetic Ketoacidosis ◽

Calcium Binding ◽

Binding Protein ◽

Neuron Specific Enolase ◽

Calcium Binding Protein ◽

S100 Calcium Binding Protein ◽

Serum Neuron Specific Enolase ◽

Protein B

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Acute Sleep Deprivation Increases Serum Levels of Neuron-Specific Enolase (NSE) and S100 Calcium Binding Protein B (S-100B) in Healthy Young Men

SLEEP ◽

10.5665/sleep.3336 ◽

2014 ◽

Vol 37 (1) ◽

pp. 195-198 ◽

Cited By ~ 38

Author(s):

Christian Benedict ◽

Jonathan Cedernaes ◽

Vilmantas Giedraitis ◽

Emil K. Nilsson ◽

Pleunie S. Hogenkamp ◽

...

Keyword(s):

Sleep Deprivation ◽

Calcium Binding ◽

Binding Protein ◽

Neuron Specific Enolase ◽

Young Men ◽

Serum Levels ◽

Calcium Binding Protein ◽

S100 Calcium Binding Protein ◽

Acute Sleep Deprivation ◽

Protein B

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Elevated neuron-specific enolase and S100 calcium-binding protein B concentrations in cerebrospinal fluid of patients with anti -N -methyl- d -aspartate receptor encephalitis

Clinica Chimica Acta ◽

10.1016/j.cca.2018.01.016 ◽

2018 ◽

Vol 480 ◽

pp. 79-83 ◽

Cited By ~ 8

Author(s):

Baozhu Liu ◽

Zuoshan Xie ◽

Guanghui Liu ◽

Yong Gu ◽

Suyue Pan ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Calcium Binding ◽

Binding Protein ◽

Neuron Specific Enolase ◽

Calcium Binding Protein ◽

Aspartate Receptor ◽

S100 Calcium Binding Protein ◽

Protein B

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Brain injury markers: S100 calcium-binding protein B, neuron-specific enolase and glial fibrillary acidic protein in children with diabetic ketoacidosis

Pediatric Diabetes ◽

10.1111/pedi.12667 ◽

2018 ◽

Vol 19 (5) ◽

pp. 1000-1006

Author(s):

Gönül Çatlı ◽

Ahmet Anık ◽

Sezer Acar ◽

Tuncay Küme ◽

Melike Karabulut ◽

...

Keyword(s):

Brain Injury ◽

Glial Fibrillary Acidic Protein ◽

Diabetic Ketoacidosis ◽

Calcium Binding ◽

Binding Protein ◽

Neuron Specific Enolase ◽

Calcium Binding Protein ◽

Acidic Protein ◽

S100 Calcium Binding Protein ◽

Protein B

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Elevated neuron-specific enolase level is associated with postoperative delirium and detection of phosphorylated neurofilament heavy subunit: A prospective observational study

PLoS ONE ◽

10.1371/journal.pone.0259217 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0259217

Author(s):

Kazuhito Mietani ◽

Maiko Hasegawa-Moriyama ◽

Reo Inoue ◽

Toru Ogata ◽

Nobutake Shimojo ◽

...

Keyword(s):

Observational Study ◽

Calcium Binding ◽

Postoperative Delirium ◽

Prospective Observational Study ◽

Binding Protein ◽

Neuron Specific Enolase ◽

Calcium Binding Protein ◽

Link Type ◽

S100 Calcium Binding Protein ◽

Serum Neuron Specific Enolase

Background Delirium is the most common central nervous system complication after surgery. Detection of phosphorylated neurofilament heavy subunit in the serum reflects axonal damage within the central cervous system and is associated with the severity of postoperative delirium. Neuron-specific enolase and S100 calcium-binding protein β have been identified as possible serum biomarkers of postoperative delirium. This study examined the association of the levels of these markers with incidence of postoperative delirium and detection of phosphorylated neurofilament heavy subunit. Methods This study represents a post hoc analysis of 117 patients who participated in a prospective observational study of postoperative delirium in patients undergoing cancer surgery. Patients were clinically assessed for development of postoperative delirium within the first five days of surgery. Serum levels of phosphorylated neurofilament heavy subunit, neuron-specific enolase, and S100 calcium-binding protein β levels were measured on postoperative day 3. Results Forty-one patients (35%) were clinically diagnosed with postoperative delirium. Neuron-specific enolase level (P < 0.0001) and the proportion of patients positive for phosphorylated neurofilament heavy subunit (P < 0.0001) were significantly higher in the group of patients with postoperative delirium. Neuron-specific enolase level discriminated between patients with and without clinically diagnosed postoperative delirium with significantly high accuracy (area under the curve [AUC], 0.87; 95% confidence interval [CI], 0.79–0.95; P < 0.0001). Neuron-specific enolase level was associated with incidence of postoperative delirium independently of age (adjusted odds ratio, 8.291; 95% Cl, 3.506−33.286; P < 0.0001). The AUC for the serum neuron-specific enolase level in detecting phosphorylated neurofilament heavy subunit was significant (AUC, 0.78; 95% CI, 0.66–0.90; P < 0.0001). Conclusion Elevated serum neuron-specific enolase was associated with postoperative delirium independent of age as well as detection of phosphorylated neurofilament heavy subunit in serum. Serum neuron-specific enolase and phosphorylated neurofilament heavy subunit might be useful as biomarkers of postoperative delirium. Trial registration University Medical Information Network (UMIN) trial ID: UMIN000010329; https://clinicaltrials.gov/.

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