scholarly journals Elevated neuron-specific enolase level is associated with postoperative delirium and detection of phosphorylated neurofilament heavy subunit: A prospective observational study

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259217
Author(s):  
Kazuhito Mietani ◽  
Maiko Hasegawa-Moriyama ◽  
Reo Inoue ◽  
Toru Ogata ◽  
Nobutake Shimojo ◽  
...  
Keyword(s):  
Observational Study ◽  
Calcium Binding ◽  
Postoperative Delirium ◽  
Prospective Observational Study ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
Link Type ◽  
S100 Calcium Binding Protein ◽  
Serum Neuron Specific Enolase

Background Delirium is the most common central nervous system complication after surgery. Detection of phosphorylated neurofilament heavy subunit in the serum reflects axonal damage within the central cervous system and is associated with the severity of postoperative delirium. Neuron-specific enolase and S100 calcium-binding protein β have been identified as possible serum biomarkers of postoperative delirium. This study examined the association of the levels of these markers with incidence of postoperative delirium and detection of phosphorylated neurofilament heavy subunit. Methods This study represents a post hoc analysis of 117 patients who participated in a prospective observational study of postoperative delirium in patients undergoing cancer surgery. Patients were clinically assessed for development of postoperative delirium within the first five days of surgery. Serum levels of phosphorylated neurofilament heavy subunit, neuron-specific enolase, and S100 calcium-binding protein β levels were measured on postoperative day 3. Results Forty-one patients (35%) were clinically diagnosed with postoperative delirium. Neuron-specific enolase level (P < 0.0001) and the proportion of patients positive for phosphorylated neurofilament heavy subunit (P < 0.0001) were significantly higher in the group of patients with postoperative delirium. Neuron-specific enolase level discriminated between patients with and without clinically diagnosed postoperative delirium with significantly high accuracy (area under the curve [AUC], 0.87; 95% confidence interval [CI], 0.79–0.95; P < 0.0001). Neuron-specific enolase level was associated with incidence of postoperative delirium independently of age (adjusted odds ratio, 8.291; 95% Cl, 3.506−33.286; P < 0.0001). The AUC for the serum neuron-specific enolase level in detecting phosphorylated neurofilament heavy subunit was significant (AUC, 0.78; 95% CI, 0.66–0.90; P < 0.0001). Conclusion Elevated serum neuron-specific enolase was associated with postoperative delirium independent of age as well as detection of phosphorylated neurofilament heavy subunit in serum. Serum neuron-specific enolase and phosphorylated neurofilament heavy subunit might be useful as biomarkers of postoperative delirium. Trial registration University Medical Information Network (UMIN) trial ID: UMIN000010329; https://clinicaltrials.gov/.

scholarly journals Serum neuron-specific enolase and S100 calcium binding protein B biomarker levels do not improve diagnosis of acute stroke

2012 ◽  
Vol 42 (3) ◽  
pp. 199-204 ◽  
Author(s):  
S González-García ◽  
A González-Quevedo ◽  
M Peña-Sánchez ◽  
C Menéndez-Saínz ◽  
R Fernández-Carriera ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
S100 Calcium Binding Protein ◽  
Serum Neuron Specific Enolase ◽  
Protein B

scholarly journals Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis

2019 ◽  
Vol 11 (4) ◽  
pp. 374-387 ◽  
Author(s):  
Hatem Hamed Elshorbagy ◽  
Naglaa Fathy Barseem ◽  
Akram Elshafey Elsadek ◽  
Ashraf Hamed Al-shokary ◽  
Yehia Hamed Abdel Maksoud ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
S100 Calcium Binding Protein ◽  
Serum Neuron Specific Enolase ◽  
Protein B

Effects of Foot-Strike Patterns on Biomarkers S100 Calcium-Binding Protein B/Neuron-Specific Enolase in Running—A Pilot Study

2020 ◽  
Vol 15 (6) ◽  
pp. 900-902
Author(s):  
Jan Schroeder ◽  
Franziska Erthel ◽  
Karsten Hollander
Keyword(s):  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Calcium Binding Protein ◽  
Significant Interaction Effect ◽  
Impact Forces ◽  
S100 Calcium Binding Protein ◽  
Foot Strike ◽  
Recreational Runners ◽  
Protein B

Purpose: Foot-strike patterns (FSP) in running are related to certain impact kinetics during ground contact. A rear-foot strike (RFS) has been associated with higher impact forces, whereas a forefoot strike (FFS) is assumed to minimize these impact forces. This study investigated the effects of running with RFS or FFS on impact-sensitive neuronal biomarkers S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and lactate dehydrogenase (LDH). Methods: In this randomized crossover study, 18 healthy recreational runners (14 male, mean [SD] age 28.2 [4.7] y, body mass index 22.8 [1.9]) ran 2 separate 5-mile runs with RFS or FFS, respectively. Blood samples were taken before (pre), 30 min after (post 0), and 24 h after (post 24) the run. S100B, NSE, and LDH concentrations were determined and analyzed (3 × 2 data model). Results: S100B, NSE, and LDH concentrations increased from pre to post 0 and decreased within 24 h back to the baseline level, demonstrating a significant time effect (all P < .01, all ). No main effect for FSP or any significant interaction effect indicating FSP-specific differences between FFS or RFS was found (all P > .05, all ), except for LDH (P < .001, ). Conclusions: NSE, S100B, and LDH concentration increased in the short term after running and returned to normal in 24 h. FSP with varying impact forces does not influence the increase of these biomarkers. LDH findings favor peripheral origins, but mixed effects are possible. Thus, further research is needed to estimate the risk of mild traumatic encephalopathy.

scholarly journals Intraoperative Oxidative Damage and Delirium after Cardiac Surgery

2020 ◽  
Vol 132 (3) ◽  
pp. 551-561 ◽  
Author(s):  
Marcos G. Lopez ◽  
Christopher G. Hughes ◽  
Anthony DeMatteo ◽  
Jason B. O’Neal ◽  
J. Brennan McNeil ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Blood Brain Barrier ◽  
Calcium Binding ◽  
Postoperative Delirium ◽  
Binding Protein ◽  
Neuronal Injury ◽  
Calcium Binding Protein ◽  
Brain Barrier ◽  
S100 Calcium Binding Protein ◽  
Carboxyl Terminal

Abstract Background Mechanisms of postoperative delirium remain poorly understood, limiting development of effective treatments. We tested the hypothesis that intraoperative oxidative damage is associated with delirium and neuronal injury and that disruption of the blood–brain barrier modifies these associations. Methods In a prespecified cohort study of 400 cardiac surgery patients enrolled in a clinical trial of atorvastatin to reduce kidney injury and delirium, we measured plasma concentrations of F2-isoprostanes and isofurans using gas chromatography-mass spectrometry to quantify oxidative damage, ubiquitin carboxyl-terminal hydrolase isozyme L1 to quantify neuronal injury, and S100 calcium-binding protein B using enzyme-linked immunosorbent assays to quantify blood–brain barrier disruption before, during, and after surgery. We performed the Confusion Assessment Method for the Intensive Care Unit twice daily to diagnose delirium. We measured the independent associations between intraoperative F2-isoprostanes and isofurans and delirium (primary outcome) and postoperative ubiquitin carboxyl-terminal hydrolase isozyme L1 (secondary outcome), and we assessed if S100 calcium-binding protein B modified these associations. Results Delirium occurred in 109 of 400 (27.3%) patients for a median (10th, 90th percentile) of 1.0 (0.5, 3.0) days. In the total cohort, plasma ubiquitin carboxyl-terminal hydrolase isozyme L1 concentration was 6.3 ng/ml (2.7, 14.9) at baseline and 12.4 ng/ml (7.9, 31.2) on postoperative day 1. F2-isoprostanes and isofurans increased throughout surgery, and the log-transformed sum of intraoperative F2-isoprostanes and isofurans was independently associated with increased odds of postoperative delirium (odds ratio, 3.70 [95% CI, 1.41 to 9.70]; P = 0.008) and with increased postoperative ubiquitin carboxyl-terminal hydrolase isozyme L1 (ratio of geometric means, 1.42 [1.11 to 1.81]; P = 0.005). The association between increased intraoperative F2-isoprostanes and isofurans and increased postoperative ubiquitin carboxyl-terminal hydrolase isozyme L1 was amplified in patients with elevated S100 calcium-binding protein B (P = 0.049). Conclusions Intraoperative oxidative damage was associated with increased postoperative delirium and neuronal injury, and the association between oxidative damage and neuronal injury was stronger among patients with increased blood–brain barrier disruption. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

scholarly journals Acute Sleep Deprivation Increases Serum Levels of Neuron-Specific Enolase (NSE) and S100 Calcium Binding Protein B (S-100B) in Healthy Young Men

SLEEP ◽  
2014 ◽  
Vol 37 (1) ◽  
pp. 195-198 ◽  
Author(s):  
Christian Benedict ◽  
Jonathan Cedernaes ◽  
Vilmantas Giedraitis ◽  
Emil K. Nilsson ◽  
Pleunie S. Hogenkamp ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Calcium Binding ◽  
Binding Protein ◽  
Neuron Specific Enolase ◽  
Young Men ◽  
Serum Levels ◽  
Calcium Binding Protein ◽  
S100 Calcium Binding Protein ◽  
Acute Sleep Deprivation ◽  
Protein B
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