Identification of an oxidizing leachable from a clinical syringe rubber stopper

Author(s):  
Ariane Schröter ◽  
Sonja Peter ◽  
Hanns-Christian Mahler ◽  
Andreas Zerr ◽  
Ombeline Danton ◽  
...  
Keyword(s):  
1994 ◽  
Vol 3 (6) ◽  
pp. 448-451 ◽  
Author(s):  
T Buckley ◽  
SM Dudley ◽  
LG Donowitz

BACKGROUND. Recommendations in the literature conflict on the necessity of disinfecting single-use vials prior to aspiration of fluid. Interventions to disinfect the stopper surface on multiple-dose vials vary considerably. OBJECTIVES. To determine the necessity of alcohol disinfection of the stopper on single-dose vials and to compare povidone-iodine and alcohol versus alcohol-only disinfection of the stopper prior to each needle penetration on multiple-dose vials. METHODS. The rubber stopper surfaces of 100 single-dose vials were cultured for the presence of bacteria. To determine the efficacy of two procedures for disinfection of multiple-dose vials, 87 stopper surfaces routinely disinfected with both povidone-iodine and alcohol were cultured for bacteria. After a change in practice, 100 multiple-dose vials routinely disinfected with alcohol only were cultured for the presence of bacteria. RESULTS. Of the cultures done on single-dose vial stoppers, 99% were sterile. A comparison of the two disinfection techniques for multiple-dose vials revealed that 83 (95%) of the 87 vials prepped with both povidone-iodine and alcohol were sterile, compared with all stoppers disinfected with alcohol only. CONCLUSIONS. This study shows the lack of necessity of any disinfection procedure on the rubber stopper of single-dose vials and the efficacy of alcohol only for disinfecting the stopper of multiple-dose vials.


1985 ◽  
Vol 48 (4) ◽  
pp. 325-326 ◽  
Author(s):  
R. HILSHEIMER ◽  
A. H. W. HAUSCHILD

The salt crystal method of Northolt and Heuvelman (J. Food Prot. 45:537–540, 1982) for testing the water activity of foods was modified to facilitate the recognition of crystal liquefaction. The proposed device is assembled from basic laboratory ware, i.e., an Erlenmeyer flask, a rubber stopper and a test tube.


2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Min Zhao ◽  
Xianhui Li ◽  
Di Zhang ◽  
Longshan Zhao

Objective. To establish a method for extraction and determination of antioxidant 264 (2,6-di-tert-butyl-4-methylphenol) in the brominated butyl rubber stopper for injection and migration study in recombinant potent antitumor and antivirus protein injection (Novaferon). Methods. Dichloromethane-ethanol was adopted as the extraction solvent during the process of reflux extraction of antioxidant 264 in the brominated butyl rubber stopper. High-performance liquid chromatography (HPLC) was used for the determination of the migration of antioxidant 264 to Novaferon. The mobile phase consisted of acetonitrile-water (80 : 20, v/v). The flow rate was 1.5 mL/min. The detection wavelength was 280 nm. Results. The linearity range was from 4.003 to 200.150 μg/mL (r2 = 0.99996), and the average recovery of antioxidant 264 was 97.8%. The applicability of the methodology was good, which can be used for the determination of antioxidant 264. The results indicated that antioxidant 264 was not detected in Novaferon after the accelerated test and three months of long-term test. Conclusion. The established validated method in this study can be used for the determination of antioxidant 264 in the rubber stopper, and the brominated butyl rubber stopper has good compatibility with Novaferon.


1961 ◽  
Vol 42 (5) ◽  
pp. 311-313
Author(s):  
F. B. Gomm

This article describes a modified collection unit for the standard Weather Bureau-type rain gage. The described unit, consisting of a polyethylene bottle, rubber stopper, vent tube and adapter funnel, replaces the metal collection tube of the standard gage. In a laboratory test, evaporation from the modified system was not great enough in a 30-day period to measure with a standard measuring tube. Field tests showed the described unit superior to the standard collection unit and equal to the standard unit with a 0.20-inch oil film in the reduction of evaporation. The described unit, which eliminates recharging with oil or antifreeze after each reading, has been in field use for two years without damage from freezing.


1988 ◽  
Vol 125 ◽  
Author(s):  
Fred Trembour ◽  
Franklin L. Smith ◽  
Irving Friedman

ABSTRACTThe rate of many processes, including the diffusion of water into rhyolitic volcanic glass (obsidian), as well as the racemization of amino acids is temperature dependent, and a knowledge of temperatures integrated over time periods of at least a year is necessary to quantify these processes. The construction and properties of simple devices consisting of small plastic containers that change weight at a rate that is a function of temperature and the activity of water will be described. The cells function because water diffuses through the plastic across a constant vapor-pressure gradient. This vapor-pressure gradient is maintained constant between the substances within the cell and the materials outside the cell. The plastic cells are usually filled with water and surrounded by a dehydrating agent, such as silica gel. A better arrangement is to fill the cell with a mixture of solid sodium chloride (NaCl) and a saturated solution of NaCl, and to surround the cell with pure water. A number of plastics have been investigated, including polycarbonate, polystyrene, tefzel, polyallomer, and methacrylate. The cells have been sealed by various methods including screw caps, room-temperature vulcanizing silicone rubber sealant, and rubber stoppers. The final design consists of a small cell made of a polycarbonate plastic centrifuge tube containing solid NaCl plus NaCl-saturated solution sealed with a rubber stopper and placed in a polypropylene tube containing pure water. Our aim has been to develop cells that are sufficiently sensitive to yield a precision of ±0.2°C when exposed for one year at temperatures that range from 0° to 40°, and that will fit into metal fittings that can be screwed into standard 3/4-inch plastic water pipe (approximately 1 inch outside diameter).


2012 ◽  
Vol 23 (2) ◽  
pp. 424-427 ◽  
Author(s):  
Raphael Campagna ◽  
Eric Pessis ◽  
Henri Guerini ◽  
Antoine Feydy ◽  
Jean-Luc Drapé

2020 ◽  
Vol 74 (6) ◽  
pp. 688-692
Author(s):  
Lara Nonis ◽  
Martin Vogt ◽  
Susanne Joerg ◽  
Hanns-Christian Mahler ◽  
Franziska Riesen ◽  
...  

1994 ◽  
Vol 71 (1) ◽  
pp. 74
Author(s):  
L. Christine L. Cargille
Keyword(s):  

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