Effect of traditional medicine brahmi vati and bacoside A-rich fraction of Bacopa monnieri on acute pentylenetetrzole-induced seizures, amphetamine-induced model of schizophrenia, and scopolamine-induced memory loss in laboratory animals

2018 ◽  
Vol 80 ◽  
pp. 144-151 ◽  
Author(s):  
Amrita Mishra ◽  
Arun K. Mishra ◽  
Shivesh Jha
Keyword(s):  
Traditional Medicine ◽  
Memory Loss ◽  
Bacopa Monnieri ◽  
Laboratory Animals ◽  
Bacoside A

scholarly journals Pharmacognostic, physicochemical and phytochemical investigation of Bacopa monnieri L. stem and its anticonvulsant potential in laboratory animals

2015 ◽  
Vol 02 (01) ◽  
pp. 019-027
Author(s):  
Amrita Mishra ◽  
Arun Mishra ◽  
Om PrakashTiwari ◽  
Shivesh Jha
Keyword(s):  
Quantitative Estimation ◽  
Ethanolic Extract ◽  
Bacopa Monnieri ◽  
Water Soluble ◽  
Laboratory Animals ◽  
Alcoholic Extract ◽  
Bacoside A ◽  
Phytochemical Study ◽  
Marker Compound ◽  
Phytochemical Investigation

Abstract Aim The aim of present work was to study the pharmacognostic standardization, physicochemical, phytochemical and pharmacological evaluation of the stem of Bacopa monnieri L. Method Standard method was followed for pharmacognostic, physicochemical, and phytochemical study. For quantitative analysis, HPTLC technique was employed. Maximal electroconvulsive shock (MES) and pentylenetetrazole (PTZ) method was used for anticonvulsant evaluation. Result Microscopic study of the stem showed presence of epidermis and cortex having large intercellular spaces. The oval shaped starch grains were present in cells of cortex and endodermis. Total ash (5.98%), water-soluble ash (4.91%), acid-insoluble ash (3.96%), water soluble extractive (15.31%) and ethanol soluble extractive (6.74%) values were evaluated for physicochemical evaluations. Quantitative estimation of Bacoside A (marker compound) by HPTLC technique was performed. The linearity (100–600 ng), the % recovery (97.81% w/w) were estimated. The Bacoside A in the alcoholic extract was found to be higher than that of the other extracts. The proposed HPTLC method was found to be simple and accurate. The anticonvulsant activities of all the extracts were evaluated by MES and PTZ models in mice. Conclusion The least anticonvulsant potential was recorded for acetone extract in dose of 100 mg/kg and maximum anticonvulsant action was recorded for ethanolic extract in dose of 300 mg/kg.

Bacoside-A, an Indian Traditional-Medicine Substance, Inhibits β-Amyloid Cytotoxicity, Fibrillation, and Membrane Interactions

2017 ◽  
Vol 8 (4) ◽  
pp. 884-891 ◽  
Author(s):  
Ravit Malishev ◽  
Shira Shaham-Niv ◽  
Sukhendu Nandi ◽  
Sofiya Kolusheva ◽  
Ehud Gazit ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Bacoside A ◽  
Membrane Interactions ◽  
Β Amyloid

Statistical optimization for enhanced bacoside A production in plant cell cultures of Bacopa monnieri

2017 ◽  
Vol 133 (2) ◽  
pp. 203-214 ◽  
Author(s):  
J. Leonard ◽  
Bishwanath Seth ◽  
Binod B. Sahu ◽  
V. R. Singh ◽  
Nivedita Patra
Keyword(s):  
Plant Cell ◽  
Cell Cultures ◽  
Bacopa Monnieri ◽  
Statistical Optimization ◽  
Plant Cell Cultures ◽  
Bacoside A

Methyl jasmonate mediates upregulation of bacoside A production in shoot cultures of Bacopa monnieri

2013 ◽  
Vol 35 (7) ◽  
pp. 1121-1125 ◽  
Author(s):  
Poojadevi Sharma ◽  
Sheetal Yadav ◽  
Anshu Srivastava ◽  
Neeta Shrivastava
Keyword(s):  
Methyl Jasmonate ◽  
Bacopa Monnieri ◽  
Shoot Cultures ◽  
Bacoside A

Elite genotypes of Bacopa monnieri , with high contents of Bacoside A and Bacopaside I, from southern Western Ghats in India

2017 ◽  
Vol 98 ◽  
pp. 76-81 ◽  
Author(s):  
Cinthya Christopher ◽  
Anil John Johnson ◽  
Paravanparampil Jacob Mathew ◽  
Sabulal Baby
Keyword(s):  
Western Ghats ◽  
Bacopa Monnieri ◽  
Bacoside A ◽  
Southern Western Ghats

Development and Validation of a Novel, Rapid Gradient HPLC Method for Simultaneous Estimation of Bioactive Marker Compounds in a Mixture of Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri Extracts

2019 ◽  
Vol 57 (10) ◽  
pp. 920-930 ◽  
Author(s):  
Sunayna Choudhary ◽  
Indu Pal Kaur ◽  
Jai Malik
Keyword(s):  
Withania Somnifera ◽  
Therapeutic Option ◽  
Herbal Medicines ◽  
Hplc Method ◽  
Bacopa Monnieri ◽  
Withaferin A ◽  
Simultaneous Estimation ◽  
Bacoside A ◽  
Convolvulus Pluricaulis ◽  
Development And Validation

Abstract The use of herbs as medicine is an ancient form of healthcare known to mankind. Standardization of herbal medicines is however a challenging task and is the major bottleneck in their acceptance as the primary therapeutic option. The aim of this study was to develop and validate a simple, rapid HPLC method for standardizing the mixture of extracts of three Medhya Rasayanas (neurotonic), Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri. Simultaneous estimation of the respective bioactive markers of these plants viz., scopoletin, withaferin A, bacoside A 3, bacopaside II, jujubogenin and bacosaponin C has been reported for the first time. The method was developed using Waters Hybrid X-Bridge shield with BEH technology 2.5 μm, 4.6 × 75 mm column and validated according to ICH guidelines. The 20 minutes run time makes the method eco-friendly. The method was linear over a range of 12.5–400 ng/10 μL for scopoletin and 62.5–2,000 ng/10 μL for withaferin A, bacoside A 3, bacopaside II, jujubogenin and bacosaponin C with detection limits of 8.0, 48.3, 30.4, 40.7, 15.6 and 18.9 ng/10 μL and quantification limits of 24.5, 146.5, 92.2, 123.4, 47.4 and 57.4 ng/10 μL, respectively. The correlation coefficient for each analyte was >0.999. The intra-day and inter-day precision was <2%. These results confirmed the precision, accuracy and robustness of the proposed method.

Wound healing and protease inhibition activity of Bacoside-A, isolated from Bacopa monnieri wettest

2010 ◽  
Vol 24 (8) ◽  
pp. 1217-1222 ◽  
Author(s):  
R. Sharath ◽  
B.G. Harish ◽  
V. Krishna ◽  
B.N. Sathyanarayana ◽  
H.M. Kumara Swamy
Keyword(s):  
Wound Healing ◽  
Bacopa Monnieri ◽  
Inhibition Activity ◽  
Bacoside A ◽  
Protease Inhibition

Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficits

Fitoterapia ◽  
2010 ◽  
Vol 81 (5) ◽  
pp. 315-322 ◽  
Author(s):  
Jobin Mathew ◽  
Jes Paul ◽  
M.S. Nandhu ◽  
C.S. Paulose
Keyword(s):  
Bacopa Monnieri ◽  
Bacoside A ◽  
Behavioral Deficits
Sign in / Sign up

Export Citation Format

Share Document