Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma

Ovarian borderline serous tumors present with peritoneal involvement in 20% of cases, either as non-invasive or invasive implants, the latter also known as extraovarian low-grade serous carcinoma. The coexistence of high-grade serous carcinoma is rare, suggesting a synchronous neoplasia with a distinct and independent tumor biology and behavior. We aim to describe a case of a synchronous ovary-peritoneum neoplasia: serous borderline tumor and primary peritoneal high-grade serous carcinoma. A discussion and literature review concerning the optimal diagnostic and therapeutic approach is provided.

Download Full-text

MR imaging findings of low-grade serous carcinoma of the ovary: comparison with serous borderline tumor

Japanese Journal of Radiology ◽

10.1007/s11604-020-00960-2 ◽

2020 ◽

Vol 38 (8) ◽

pp. 782-789

Author(s):

Masaya Kawaguchi ◽

Hiroki Kato ◽

Yuichiro Hatano ◽

Hiroyuki Tomita ◽

Akira Hara ◽

...

Keyword(s):

Mr Imaging ◽

Serous Carcinoma ◽

Low Grade ◽

Borderline Tumor ◽

Imaging Findings ◽

Serous Borderline Tumor ◽

Carcinoma Of The Ovary

Download Full-text

Case Report: Borderline tumor and primary peritoneal carcinoma - a rare synchronism

F1000Research ◽

10.12688/f1000research.20420.1 ◽

2019 ◽

Vol 8 ◽

pp. 1630

Author(s):

Mariana Rei ◽

Sofia Raposo ◽

Paulo Figueiredo ◽

Rita Sousa ◽

Luís Sá

Keyword(s):

Tumor Biology ◽

Serous Carcinoma ◽

Low Grade ◽

Borderline Tumor ◽

High Grade ◽

Peritoneal Carcinoma ◽

Non Invasive ◽

Serous Borderline Tumor ◽

And Behavior ◽

Serous Tumors

Ovarian borderline serous tumors present with peritoneal involvement in 20% of cases, either as non-invasive or invasive implants, also known as extraovarian low-grade serous carcinoma. The coexistence of high-grade serous carcinoma is rare, suggesting a synchronous neoplasia with a distinct and independent tumor biology and behavior. We aim to describe a case of a synchronous ovary-peritoneum neoplasia: serous borderline tumor and primary peritoneal high-grade serous carcinoma. A discussion and literature review concerning the optimal diagnostic and therapeutic approach is provided.

Download Full-text

Progressive loss of selenium-binding protein 1 expression correlates with increasing epithelial proliferation and papillary complexity in ovarian serous borderline tumor and low-grade serous carcinoma

Human Pathology ◽

10.1016/j.humpath.2009.07.019 ◽

2010 ◽

Vol 41 (2) ◽

pp. 255-261 ◽

Cited By ~ 11

Author(s):

Cunxian Zhang ◽

Yu Edmond Wang ◽

Peng Zhang ◽

Fang Liu ◽

C. James Sung ◽

...

Keyword(s):

Binding Protein ◽

Serous Carcinoma ◽

Low Grade ◽

Borderline Tumor ◽

Epithelial Proliferation ◽

Serous Borderline Tumor ◽

Progressive Loss

Download Full-text

ECTOPIC PREGNANCY

The Professional Medical Journal ◽

10.29309/tpmj/2011.18.01.1852 ◽

2011 ◽

Vol 18 (01) ◽

pp. 24-27

Author(s):

AFROZA ABBAS ◽

H. AKRAM

Keyword(s):

Ectopic Pregnancy ◽

Pelvic Inflammatory Disease ◽

Inflammatory Disease ◽

International Studies ◽

Reproductive Health Care ◽

Nulliparous Women ◽

Causative Factors ◽

Contraceptive Utilization ◽

Labour Room ◽

Timely Referral

Objective: To find out the causative factors for rising rate of ectopic pregnancy in young women at periphery. Design: Descriptive study. Place and Duration of Study: Maula Bakhsh Teaching Hospital ( Obstetrical and gynaecological unit) Sargodha , from January 2008 – December 2008. Patients and Methods: All patients who were presented in labour room emergency and gynaecological out patients department with confirmed diagnosis of ectopic pregnancy on USG were included in the study. A pre-formed proforma was used to record the details about the demographic features, pre-existing risk factors for ectopic pregnancy, clinical features at presentation and management. Results: Frequency of ectopic pregnancy was too high in our study compared to international studies. Majority of patients were young and nullipara. Leading risk factor is pelvic inflammatory disease due to septic induced abortion. 92% of patients had acute presentation. Conclusions: Rising rate of ectopic pregnancy was found in young, nulliparous women secondary to pelvic inflammatory disease. The frequency can be reduced by awareness of reproductive health care, liberal contraceptive utilization, acceptable adequate planned family. Early diagnosis and timely referral may be helpful in treating the patients prior to tubal rupture with decreased morbidity and mortality.

Download Full-text

Ten years transmission of the new variant of Chlamydia trachomatis in Sweden: prevalence of infections and associated complications

Sexually Transmitted Infections ◽

10.1136/sextrans-2016-052992 ◽

2017 ◽

Vol 94 (2) ◽

pp. 100-104 ◽

Cited By ~ 9

Author(s):

Jenny Dahlberg ◽

Ronza Hadad ◽

Karin Elfving ◽

Inger Larsson ◽

Jenny Isaksson ◽

...

Keyword(s):

Chlamydia Trachomatis ◽

Ectopic Pregnancy ◽

Pelvic Inflammatory Disease ◽

Inflammatory Disease ◽

Complication Rates ◽

Becton Dickinson ◽

Specific Pcr ◽

Single Target ◽

New Variant ◽

Low Prevalence

ObjectivesIn 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications.MethodsC. trachomatis-positive specimens collected from 2007 to 2015 were analysed by a specific PCR to identify nvCT cases. Genotyping was performed by multilocus sequence typing (MLST) and ompA sequencing. Ectopic pregnancy and pelvic inflammatory disease records were extracted from the national registers.ResultsIn total, 5101 C. trachomatis-positive samples were analysed. The nvCT proportion significantly decreased in the two counties using Roche systems, from 56% in 2007 to 6.5% in 2015 (p<0.001). In the two counties using BD systems, a decrease was also seen, from 19% in 2007 to 5.2% in 2015 (p<0.001). Fifteen nvCT cases from 2015 and 102 cases from 2006 to 2009 had identical MLST profiles. Counties using Roche/Abbott systems showed higher mean rates of ectopic pregnancy and pelvic inflammatory disease compared with counties using BD systems.ConclusionsThe nvCT proportion has decreased in all counties and converged to a low prevalence irrespective of previous rates. Genotyping showed that nvCT is clonal and genetically stable. Failing detection only marginally affected complication rates.

Download Full-text

A Micropapillary Variant of Transitional Cell Carcinoma Arising in the Ureter

Archives of Pathology & Laboratory Medicine ◽

10.5858/2000-124-1347-amvotc ◽

2000 ◽

Vol 124 (9) ◽

pp. 1347-1348 ◽

Cited By ~ 2

Author(s):

Russell Vang ◽

Jacki Abrams

Keyword(s):

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Transitional Cell ◽

Inflammatory Cells ◽

World Health ◽

Serous Carcinoma ◽

Ureteral Stricture ◽

Borderline Tumor ◽

Nephrogenic Adenoma ◽

Serous Borderline Tumor

Abstract A 79-year-old woman was evaluated for a ureteral stricture related to laser ablation of a tumor 6 months earlier at another institution. A ureteroscopic examination revealed an exophytic papillary tumor that was resected and examined histologically. The tumor was characterized by delicate papillae with thin stromal cores and numerous secondary micropapillae lined by small cuboidal to low columnar cells with uniform low-to-intermediate–grade nuclei, reminiscent of a serous borderline tumor of müllerian origin. The cell linings were 1 to 4 layers thick; mitotic figures were easily identified. The underlying stroma appeared edematous and contained scattered chronic inflammatory cells. No invasion was identified. After ascertaining that the patient had no known gynecologic neoplasm, the differential diagnoses considered included papillary nephrogenic adenoma, clear cell carcinoma, and the recently described entity of micropapillary transitional cell carcinoma. Because of the striking resemblance to serous carcinoma and the presence of significant mitotic activity, this case was felt to represent a case of micropapillary transitional cell carcinoma (World Health Organization grade 1 to 2) occurring in the ureter. To our knowledge, this tumor had some unique features (no areas of grade 3 nuclei or invasion) that have not been reported in tumors occurring in the urinary bladder. The transitional cell nature of the tumor cells was supported by the immunohistochemical staining pattern. The anatomic distribution of micropapillary transitional cell carcinoma is now expanded to include the ureter, and this tumor should be considered in the differential diagnosis for papillary lesions occurring in the ureter.

Download Full-text

Pelvic inflammatory disease

Oxford Textbook of Obstetrics and Gynaecology ◽

10.1093/med/9780198766360.003.0043 ◽

2020 ◽

pp. 536-549

Author(s):

Gillian Dean ◽

Jonathan Ross

Keyword(s):

Ectopic Pregnancy ◽

Pelvic Inflammatory Disease ◽

Inflammatory Disease ◽

Severe Disease ◽

Lower Abdominal Pain ◽

Asymptomatic Infection ◽

Public Understanding ◽

Transmitted Infection ◽

Delay In Diagnosis ◽

Sexually Transmitted

Pelvic inflammatory disease is a sexually transmitted infection of the female upper genital tract. Rates of pelvic inflammatory disease have fallen in many countries over the last 10 years, at least in part due to increased screening for chlamydial infection. The clinical spectrum ranges from asymptomatic infection through to severe disease requiring hospitalization. Due to the non-specific nature of the condition, diagnosis can be challenging. All sexually active women presenting with acute lower abdominal pain should have a pregnancy test to rule out ectopic pregnancy. Treatment must be initiated as soon as the diagnosis is suspected and include antibiotics covering a broad spectrum of pathogens. Delay in diagnosis increases the risk of adverse sequelae including ectopic pregnancy and infertility. It is recommended that current and recent sexual partners receive empirical treatment, regardless of symptoms or microbiological results, and refrain from sexual contact until completion of therapy. Through better public understanding of the symptoms of pelvic inflammatory disease, women seeking earlier medical attention may reduce the risk of reproductive damage.

Download Full-text