scholarly journals A single ovarian stimulation, as performed in assisted reproductive technologies, can modulate the anxiety-like behavior and neuronal activation in stress-related brain areas in rats

2020 ◽  
Vol 124 ◽  
pp. 104805
Author(s):  
Flora França Nogueira Mariotti ◽  
Bianca Santos Martins Gonçalves ◽  
Giovanna Pimpão ◽  
Marcos Mônico-Neto ◽  
Hanna Karen Moreira Antunes ◽  
...  
Keyword(s):  
Ovarian Stimulation ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Neuronal Activation ◽  
Brain Areas

The role of the growth hormone in assisted reproductive technologies cycles

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (4) ◽  
pp. 6-8
Author(s):  
Andrey Y Romanov ◽  
Anastasiya G Syrkasheva ◽  
Nataliya V Dolgushina ◽  
Elena A Kalinina
Keyword(s):  
Growth Hormone ◽  
Live Birth ◽  
Ovarian Stimulation ◽  
Assisted Reproductive Technologies ◽  
Polycystic Ovary ◽  
Live Birth Rate ◽  
Reproductive Technologies ◽  
Blood Levels ◽  
Main Research ◽  
Poor Ovarian Responders

The paper analyzes the literature data on the use of the growth hormone (GH) in ovarian stimulation in assisted reproductive technologies (ART). Routine use of GH in ovarian stimulation in patients with a normal GH level does not increase pregnancy and childbirth rates in ART. Also, no benefits of using GH have been identified for patients with polycystic ovary syndrome, despite the increase in insulin and IGF-1 blood levels. The main research focus is to study the use of GH in patients with poor ovarian response. According to the meta-analysis conducted by X.-L. Li et al. (2017), GH in ovarian stimulation of poor ovarian responders increases the number of received oocytes, mature oocytes number, reduces the embryo transfer cancellation rate and does not affect the fertilization rate. The pregnancy and live birth rates are significantly higher in the group of GH use - by 1.65 (95% CI 1.23-2.22) and 1.73 (95% CI 1.25-2.40) times, respectively. Thus, it is advisable to use GH in ovarian stimulation in poor ovarian responders, since it allows to increases live birth rate in ART. However, further studies should determine the optimal GH dose and assesse it`s safety in ART programs.

A novel ovarian stimulation protocol for use with the assisted reproductive technologies*

1993 ◽  
Vol 60 (5) ◽  
pp. 864-870 ◽  
Author(s):  
Randle S. Corfman ◽  
Magdy P. Milad ◽  
Tracy L. Bellavance ◽  
Steven J. Ory ◽  
Lisa D. Erickson ◽  
...  
Keyword(s):  
Ovarian Stimulation ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Stimulation Protocol

Possibilities of ovarian stimulation in patients with reduced ovarian reserve

2020 ◽  
Vol 19 (5) ◽  
pp. 51-56
Author(s):  
N.L. Shamugiya ◽  
◽  
M.S. Borisova ◽  
N.M. Podzolkova ◽  
◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Comparison Group ◽  
Assisted Reproductive Technologies ◽  
Young Patients ◽  
Reproductive Technologies ◽  
Main Group ◽  
Etiological Factor ◽  
Unknown Etiology

Objective. To increase the efficiency of assisted reproductive technologies (ART) in young patients with reduced ovarian reserve after ovarian surgery. Patients and methods. 141 patients were examined. In the first group (main), 56 patients with reduced ovarian reserve after unilateral/bilateral ovarian resection were included. In the second group (comparison group) – 85 patients with reduced ovarian reserve of unknown etiology were included. Results. There were no differences in the assessment of ovarian reserve in groups (p > 0.05). Stimulation protocols in groups differed in terms of the daily and total dose of gonadotropins (p < 0.05). The main group and the comparison group differed in terms of the quality of the obtained oocytes (3.11 ± 1.69 vs 3.99 ± 2.38; p = 0.0244) and embryos (1.25 ± 1.19 vs 1.73 ± 1.55; p = 0.0465). Perinatal outcomes in groups did not differ significantly (p > 0.05), but in the main group there was a greater number of spontaneous miscarriages and premature births (3.1% versus 1.9%), which may indicate the influence of etiological factor in reducing the ovarian reserve on carrying a pregnancy. Conclusion. To increase the effectiveness of ART in patients with reduced ovarian reserve, etiological factor should be taken into account when selecting the optimal protocol for ovarian stimulation. Age is a decisive factor in the outcomes of ART in this group of patients. Key words: infertility, ovarian response, assisted reproductive technologies, ovarian reserve, ovarian stimulation, in vitro fertilization

scholarly journals The impact of ovarian stimulation for IVF on the developing embryo

Reproduction ◽  
2010 ◽  
Vol 139 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Margarida Avo Santos ◽  
Ewart W Kuijk ◽  
Nick S Macklon
Keyword(s):  
Ovarian Stimulation ◽  
Embryo Quality ◽  
Assisted Reproductive Technologies ◽  
Perinatal Outcomes ◽  
Developed Countries ◽  
Reproductive Technologies ◽  
The Past ◽  
High Doses ◽  
Underlying Mechanisms ◽  
The Impact

The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1–3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes. In this review, we consider the evidence for these effects and address possible underlying mechanisms. We conclude that such mechanisms are still poorly understood, and further knowledge is needed in order to increase the safety of ovarian stimulation and to reduce potential effects on embryo development and implantation, which will ultimately be translated into increased pregnancy rates and healthy offspring.

scholarly journals The trends of assisted reproductive technologies and cost for ovarian stimulation protocols in Ukraine

Pharmacia ◽  
2020 ◽  
Vol 67 (4) ◽  
pp. 269-276
Author(s):  
Olha Zaliska ◽  
Khrystyna Stasiv ◽  
Nataliia Maksymovych ◽  
Yaryna Hrynkiv
Keyword(s):  
Ovarian Stimulation ◽  
Medical Records ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
The State ◽  
Drug Prescriptions ◽  
Treatment Standards ◽  
Hormonal Stimulation ◽  
State Program ◽  
Number Of Cycles

The prevalence of infertility has risen 2.9 times in recent years in Ukraine. The use of assisted reproductive technologies (ART) is needed. The State program for infertility treatment by budget funds was approved in Ukraine since 2004. However, funding for this program is enough only for 500–600 cycles per year, but ART centers conducted more than 27,000 cycles in 2018. This means that many women have to pay out-of-pockets. Our research has shown that between 2000 and 2018, the number of ART clinics and the number of cycles, pregnancies, and children born increased significantly in Ukraine. The rate of ART cycles per 1 million population in Ukraine has increased from 226.9 to 655.3, but it is lower than the WHO recommended rate 800–1000 cycles per 1 million population. Changes in the structure of ART cycles for 2000–2018, the increase of ICSI, and egg donation cycles are shown. It requires an adequate supply by hormonal drugs for ovarian stimulation in ART centers. Since 2004 Ministry of Health of Ukraine annually approved the list of medicines for State program of ART. Only 8 drugs were purchased by the state funds, which amounted for USD 227 438 in 2017, 2018. A retrospective analysis of drug prescriptions in short and long stimulation protocols was performed. The frequency of drug prescriptions according to the ATC-classification based on medical records was determined, all prescriptions were accordance with the requirements of ART treatment standards in Ukraine. The costs of the three hormonal stimulation schemes, which were the most prescribing in ART center, were calculated. It was found that costs for hormonal schemes increased by 22–54% during 2015–2020, it significantly reduces the availability and affordability of ART for the population in Ukraine.

scholarly journals Predictive value of ovarian hormone-producing function assessment in poor responders undergoing assisted reproductive technologies

2020 ◽  
Vol 68 (6) ◽  
pp. 7-18
Author(s):  
Alexandra I. Merkulova ◽  
Lyailya Kh. Dzhemlikhanova ◽  
Dariko A. Niauri ◽  
Alexander M. Gzgzyan ◽  
Igor Yu. Kogan ◽  
...  
Keyword(s):  
Follicular Fluid ◽  
Ovarian Stimulation ◽  
Ovarian Function ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Fertility Treatment ◽  
Total Testosterone ◽  
Poor Responders ◽  
Aromatase Activity ◽  
Serum Estradiol

Hypothesis/aims of study. The management of poor responders to ovarian stimulation for in vitro fertilization (IVF) has always been a challenge. It is difficult for both doctors and patients to make decision to proceed to oocyte donation or abandon fertility treatment. More predictors of successful IVF treatment in poor responders are needed. The aim of this study was to assess hormonal ovarian function in poor responders undergoing ovarian stimulation and to identify predictors of the chance of clinical pregnancy after IVF cycle. Study design, materials and methods. The study included 45 infertile patients undergoing ovarian stimulation with poor ovarian response according to the Bologna criteria. All patients underwent standard IVF or IVF/ICSI protocol using gonadotropin releasing hormone antagonists. Letrozole (5 mg/day) was administered during the first 5 days of stimulation in standard antagonist FSH/hMG protocol to 13 of the patients included in the study, with standard antagonist FSH/hMG protocol being only administered to other 32 patients. Serum and follicular fluid were collected at the time of follicle aspiration, and the concentrations of total testosterone, estradiol and androstenedione were determined. Results. Follicular fluid concentrations of testosterone and androstenedione were higher and serum estradiol level was lower in the letrozole group. The serum concentrations of testosterone and androstenedione were comparable in both groups, while the serum estradiol/testosterone ratio was lower in the letrozole group. The threshold level of estradiol/testosterone ratio 1000 on the day of oocyte retrieval above which pregnancy and implantation rates were increased was 1532.68 (odds ratio 7.0 (95% CI 1.3935.35), р = 0.02). Conclusion. Evaluating of the serum estradiol / testosterone ratio has been shown to determine aromatase activity of ovarian preovulatory follicles and to predict IVF outcome in poor responders undergoing assisted reproductive technology.

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