scholarly journals 987. A Cautionary Tale for Immunotherapy Using Genetically Modified Dendritic Cells; Implications for the Future Design of Vaccines

2006 ◽  
Vol 13 ◽  
pp. S380
Author(s):  
PengH. Tan ◽  
GeorgeJ.T. George
Keyword(s):  
Dendritic Cells ◽  
Genetically Modified ◽  
Cautionary Tale ◽  
Future Design ◽  
The Future

scholarly journals The Politicisation of Hybrid Courts: Observations from the Extraordinary Chambers in the Courts of Cambodia

2014 ◽  
Vol 14 (1) ◽  
pp. 115-147 ◽  
Author(s):  
Tomas Hamilton ◽  
Michael Ramsden
Keyword(s):  
United Nations ◽  
Hybrid Model ◽  
International Community ◽  
International Standards ◽  
Cautionary Tale ◽  
Future Design ◽  
International Crimes ◽  
Political Interference ◽  
The Future ◽  
National Ownership

The use of ‘hybrid’ tribunals as a means to secure accountability for international crimes seeks to combine national ownership over the trials whilst providing a framework for the inclusion of international standards and personnel in the proceedings. The Extraordinary Chambers in the Courts of Cambodia (ECCC) represents one such hybrid experiment. Yet the ECCC has faced recurring allegations of political interference. These allegations are substantial and even if not always verifiable at least create an appearance of impropriety. The failure of the ECCC and United Nations to adequately address these allegations derived from a hybrid model that failed to provide sufficient safeguards against interference. The international community agreed on a solution to secure accountability with awareness that the trials were likely to be politically tainted. As such, the experiment in Cambodia provides a cautionary tale for the future design of hybrid tribunals.

scholarly journals Concept of an Ontology for Automated Vehicle Behavior in the Context of Human-Centered Research on Automated Driving Styles

Information ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 21
Author(s):  
Johannes Ossig ◽  
Stephanie Cramer ◽  
Klaus Bengler
Keyword(s):  
Driving Behavior ◽  
Automation System ◽  
Automated Driving ◽  
Driving Style ◽  
Driving Experience ◽  
Automated Vehicle ◽  
Future Design ◽  
Vehicle System ◽  
The Future ◽  
Conceptual Distinction

In the human-centered research on automated driving, it is common practice to describe the vehicle behavior by means of terms and definitions related to non-automated driving. However, some of these definitions are not suitable for this purpose. This paper presents an ontology for automated vehicle behavior which takes into account a large number of existing definitions and previous studies. This ontology is characterized by an applicability for various levels of automated driving and a clear conceptual distinction between characteristics of vehicle occupants, the automation system, and the conventional characteristics of a vehicle. In this context, the terms ‘driveability’, ‘driving behavior’, ‘driving experience’, and especially ‘driving style’, which are commonly associated with non-automated driving, play an important role. In order to clarify the relationships between these terms, the ontology is integrated into a driver-vehicle system. Finally, the ontology developed here is used to derive recommendations for the future design of automated driving styles and in general for further human-centered research on automated driving.

scholarly journals A Roadmap for the Future Design of Human-Robot Collaboration

2020 ◽  
Vol 53 (2) ◽  
pp. 10196-10201
Author(s):  
Hans-Jürgen Buxbaum ◽  
Sumona Sen ◽  
Ruth Häusler
Keyword(s):  
Future Design ◽  
The Future ◽  
Human Robot Collaboration

scholarly journals Tripeptide Self-Assembly into Bioactive Hydrogels: Effects of Terminus Modification on Biocatalysis

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 173
Author(s):  
Marina Kurbasic ◽  
Ana M. Garcia ◽  
Simone Viada ◽  
Silvia Marchesan
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Chemical Modifications ◽  
Ability To Work ◽  
Active Compounds ◽  
Future Design ◽  
Self Organized ◽  
The Future ◽  
Bio Material ◽  
Supramolecular Catalysts

Bioactive hydrogels based on the self-assembly of tripeptides have attracted great interest in recent years. In particular, the search is active for sequences that are able to mimic enzymes when they are self-organized in a nanostructured hydrogel, so as to provide a smart catalytic (bio)material whose activity can be switched on/off with assembly/disassembly. Within the diverse enzymes that have been targeted for mimicry, hydrolases find wide application in biomaterials, ranging from their use to convert prodrugs into active compounds to their ability to work in reverse and catalyze a plethora of reactions. We recently reported the minimalistic l-His–d-Phe–d-Phe for its ability to self-organize into thermoreversible and biocatalytic hydrogels for esterase mimicry. In this work, we analyze the effects of terminus modifications that mimic the inclusion of the tripeptide in a longer sequence. Therefore, three analogues, i.e., N-acetylated, C-amidated, or both, were synthesized, purified, characterized by several techniques, and probed for self-assembly, hydrogelation, and esterase-like biocatalysis. This work provides useful insights into how chemical modifications at the termini affect self-assembly into biocatalytic hydrogels, and these data may become useful for the future design of supramolecular catalysts for enhanced performance.

Damage Assessment of Historic Earthen Sites after the 2007 Earthquake in Peru

2010 ◽  
Vol 133-134 ◽  
pp. 665-670 ◽  
Author(s):  
N. Claudia ◽  
B. Cancino
Keyword(s):  
Multidisciplinary Team ◽  
Damage Assessment ◽  
Rapid Assessment ◽  
Future Design ◽  
The Future ◽  
Earthen Buildings

The Pisco earthquake of August 15, 2007 resulted in 519 deaths and 1366 injured, with a total of 650,000 people affected and 80,000 dwellings damaged. Preliminary reports indicated that significant earthen sites were damaged. A few months after the earthquake a rapid assessment to better understand the failure of the affected sites was performed by a multidisciplinary team convened by the Getty Conservation Institute (GCI) in response to a request from the Instituto Nacional de Cultura del Perú (INC). This paper presents the highlights of that evaluation and its implications for the future design and retrofit of earthen buildings.

The Android and the Animal

PMLA ◽  
2009 ◽  
Vol 124 (2) ◽  
pp. 503-510 ◽  
Author(s):  
Ursula K. Heise
Keyword(s):  
Science Fiction ◽  
Police Officer ◽  
Human Subject ◽  
Genetically Modified ◽  
Organic Life ◽  
The Future

Pixar's animated feature wall-E (2008) revolves around a sentient robot, a small trash compactor who faith fully continues his programmed duties seven hundred years into the future, after humans have long abandoned their polluted home planet. Landscaped into skyscrapers of compacted waste, Earth no longer seems to harbor any organic life other than a cockroach, Wall-E's only and constant friend. Similarly, in Mamoru Oshii's Ghost in the Shell 2: Innocence (2004; ), sequel to the groundbreaking first Ghost in the Shell anime, the love of the cyborg police officer Batou for his vanished colleague Motoko Kusanagi is surpassed only by the care and affection he displays for his pet basset hound. These films are two recent examples of works of science fiction in which the emergence of new kinds of humanoid consciousness in robots, cyborgs, or biotechnologically produced humans is accompanied by a renewed attention to animals. Why? In what ways does the presence of wild, domestic, genetically modified, or mechanical animals reshape the concerns about the human subject that are most centrally articulated, in many of these works, through technologically produced and reproduced human minds and bodies?

scholarly journals Design Principles: Literature Review, Analysis, and Future Directions

2016 ◽  
Vol 138 (10) ◽  
Author(s):  
Katherine K. Fu ◽  
Maria C. Yang ◽  
Kristin L. Wood
Keyword(s):  
Design Science ◽  
Design Principles ◽  
Grand Challenge ◽  
Formal Approach ◽  
Design Problems ◽  
Future Directions ◽  
Future Design ◽  
The Future ◽  
Tools And Techniques ◽  
Archival Practices

Design principles are created to codify and formalize design knowledge so that innovative, archival practices may be communicated and used to advance design science and solve future design problems, especially the pinnacle, wicked, and grand-challenge problems that face the world and cross-cutting markets. Principles are part of a family of knowledge explication, which also include guidelines, heuristics, rules of thumb, and strategic constructs. Definitions of a range of explications are explored from a number of seminal papers. Based on this analysis, the authors pose formalized definitions for the three most prevalent terms in the literature—principles, guidelines, and heuristics—and draw more definitive distinctions between the terms. Current research methods and practices with design principles are categorized and characterized. We further explore research methodologies, validation approaches, semantic principle composition through computational analysis, and a proposed formal approach to articulating principles. In analyzing the methodology for discovering, deriving, formulating, and validating design principles, the goal is to understand and advance the theoretical basis of design, the foundations of new tools and techniques, and the complex systems of the future. Suggestions for the future of design principles research methodology for added rigor and repeatability are proposed.

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