Cross-sectional and longitudinal associations of lifestyle factors with depressive symptoms in ≥53-year old Taiwanese — Results of an 8-year cohort study

Abstract Background Large population-based cohort studies of neuropsychological factors that characterise or precede depressive symptoms are rare. Most studies use small case-control or cross-sectional designs, which may cause selection bias and cannot test temporality. In a large UK population-based cohort, we investigated cross-sectional and longitudinal associations between inhibitory control of positive and negative information and adolescent depressive symptoms. Methods Cohort study of 2328 UK adolescents who completed an affective go/no-go task at age 18. Depressive symptoms were assessed with the Clinical Interview Schedule Revised (CIS-R) and short Mood and Feeling Questionnaire (sMFQ) at age 18, and with the sMFQ 1 year later (age 19). Analyses were multilevel and traditional linear regressions, before and after adjusting for confounders. Results Cross-sectionally, we found little evidence that adolescents with more depressive symptoms made more inhibitory control errors [after adjustments, errors increased by 0.04% per 1 s.d. increase in sMFQ score (95% confidence interval 0.02–0.06)], but this association was not observed for the CIS-R. There was no evidence for an influence of valence. Longitudinally, there was no evidence that reduced inhibitory control was associated with future depressive symptoms. Conclusions Inhibitory control of positive and negative information does not appear to be a marker of current or future depressive symptoms in adolescents and would not be a useful target in interventions to prevent adolescent depression. Our lack of convincing evidence for associations with depressive symptoms suggests that the affective go/no-go task is not a promising candidate for future neuroimaging studies of adolescent depression.

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Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort

Psychological Medicine ◽

10.1017/s0033291719000308 ◽

2019 ◽

Vol 50 (4) ◽

pp. 556-565 ◽

Cited By ~ 4

Author(s):

B. I. Perry ◽

G. M. Khandaker ◽

S. Marwaha ◽

A. Thompson ◽

S. Zammit ◽

...

Keyword(s):

Insulin Resistance ◽

Young People ◽

Birth Cohort ◽

Lifestyle Factors ◽

Low Grade ◽

Cross Sectional ◽

Parents And Children ◽

Show Evidence ◽

Longitudinal Associations ◽

And Gender

AbstractBackgroundDepression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people.MethodsUsing the Avon Longitudinal Study of Parents and Children birth cohort, we used regression analyses to examine: (1) cross-sectional and (2) longitudinal associations between measures of DGIH [insulin resistance (IR); impaired glucose tolerance] and body mass index (BMI) at ages 9 and 18 years, and depression (depressive symptoms and depressive episode) at age 18 years and (3) whether sociodemographics, lifestyle factors or inflammation [interleukin-6 (IL-6) at age 9 years] confounded any such associations.ResultsWe included 3208 participants. At age 18 years, IR and BMI were positively associated with depression. These associations may be explained by sociodemographic and lifestyle factors. There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.ConclusionsYoung people with depression show evidence of DGIH and raised BMI, which may be related to sociodemographic and lifestyle effects such as deprivation, smoking, ethnicity and gender. In future, studies with larger samples are required to confirm this. Preventative strategies for the poorer physical health outcomes associated with depression should focus on malleable lifestyle factors.

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O20-6 Exhaustion and diurnal levels of saliva cortisol: cross-sectional and longitudinal associations in a large two-panel cohort study

10.1136/oemed-2016-103951.105 ◽

2016 ◽

Author(s):

Sigurd Mikkelsen ◽

Julie Lyng Forman ◽

Jens Peter Bonde ◽

Marianne Agergaard Vammen ◽

Åse Marie Hansen ◽

...

Keyword(s):

Cohort Study ◽

Cross Sectional ◽

Saliva Cortisol ◽

Longitudinal Associations

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Cross-Sectional and Longitudinal Associations of Neighborhood Cohesion and Stressors with Depressive Symptoms in the Multiethnic Study of Atherosclerosis

Annals of Epidemiology ◽

10.1016/j.annepidem.2008.10.002 ◽

2009 ◽

Vol 19 (1) ◽

pp. 49-57 ◽

Cited By ~ 79

Author(s):

Christina Mair ◽

Ana V. Diez Roux ◽

Mingwu Shen ◽

Steven Shea ◽

Theresa Seeman ◽

...

Keyword(s):

Depressive Symptoms ◽

Cross Sectional ◽

Neighborhood Cohesion ◽

Longitudinal Associations

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Age and gender specific association between obesity and depressive symptoms: a large-scale cross-sectional study

BMC Public Health ◽

10.1186/s12889-020-09664-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Wei Liao ◽

Zhicheng Luo ◽

Yitan Hou ◽

Ningning Cui ◽

Xiaotian Liu ◽

...

Keyword(s):

Clinical Trial ◽

Cohort Study ◽

Depressive Symptoms ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Age And Gender ◽

Specific Association ◽

And Gender ◽

Gender Specific

Abstract Background This is a cross-sectional study to explore the age and gender specific association between obesity and depression in Chinese rural adults. Methods A total of 29,900 eligible participants from the Henan Rural Cohort Study were included. Standard anthropometric measurements were undertaken to obtain data on body mass index (BMI) and waist circumference (WC). The Patient Health Questionnaire-2 (PHQ-2) was utilized to discover depressive symptoms. Logistic regression was performed to explore the association between obesity (independent variable) and depressive symptoms (dependent variable). Results There were 1777 subjects with depressive symptoms, accounting for 5.94%. After multivariable adjustment, compared with normal weight group, the odds ratios (ORs) [95% confidence interval (CI)] for depressive symptoms in underweight, overweight and general obese groups were 1.41 (1.08–1.84), 0.87 (0.78–0.97) and 0.86 (0.74–0.99), respectively. Similarly, the OR (95% CI) of abdominal obesity group was 0.84 (0.76–0.93). Besides, there was linear decreasing trend of WC with depressive symptoms, but not BMI. Moreover, the inverse association between obesity and depressive symptoms was stronger in men and the elderly than that in women and the young. Conclusion Underweight was associated with a higher prevalence of depressive symptoms, which indicated that health care should pay attention to underweight as well as obesity, especially for women and the young. Clinical trial registration The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 2015-07-06.

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