Long-term prognostic significance of isolated minor electrocardiographic T-wave abnormalities in middle-aged men free of clinical cardiovascular disease (The Multiple Risk Factor Intervention Trial [MRFIT])

2002 ◽  
Vol 90 (12) ◽  
pp. 1391-1395 ◽  
Author(s):  
Ronald J Prineas ◽  
Greg Grandits ◽  
Pentti M Rautaharju ◽  
Jerome D Cohen ◽  
Zhu Ming Zhang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Prognostic Significance ◽  
Multiple Risk Factor ◽  
Intervention Trial ◽  
Middle Aged ◽  
T Wave ◽  
Multiple Risk

The National Cooperative Trial on Multifactorial Prevention of First Heart Attacks and Coronary Mortality in Free-Living, High-Risk, Middle-Aged American Men, Also Known as JUMBO: A Short Story

2019 ◽  
Vol 189 (6) ◽  
pp. 491-498 ◽  
Author(s):  
Henry Blackburn
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Multiple Risk Factor ◽  
Intervention Trial ◽  
Heart Attacks ◽  
Heart Institute ◽  
National Heart ◽  
Multiple Risk ◽  
National Cooperative

Abstract The concept of a multiple risk-factor intervention trial (MRFIT) originated in mid-20th century efforts to determine whether modifying the “risk factors” established by cardiovascular disease epidemiology would prevent heart attacks. The term “MRFIT” probably first appeared in the 1968 report to the National Heart Institute from investigators of the National Diet-Heart Feasibility Study. Based on their pilot experience, they recommended a trial of diet alone. Aware, however, that authorities might agree with the rationale but not the implementation of such a massive and risky undertaking, they also proposed an alternative: whether coronary heart disease was preventable at all by simultaneous intervention on several risk factors; that is, a multiple risk-factor intervention trial. After some years agonizing by serial expert committees, the National Heart Institute opted against an explanatory diet trial and for a pragmatic multiple risk-factor intervention, one designed by Institute staff and operated under contract. Meanwhile, an impatient community of investigators met together in the Makarska Conference, outlined a broad cardiovascular disease prevention policy, and submitted their idealized version of a multiple risk-factor trial, called JUMBO. But the National Heart Institute, because of the plan for its own trial, had no funds left for an investigator-initiated proposal. Hence, this background and story of the MRFIT that wasn’t.

A long-term nutrition intervention experience: Lipid responses and dietary adherence patterns in the Multiple Risk Factor Intervention Trial

1986 ◽  
Vol 86 (6) ◽  
pp. 752-758
Author(s):  
Therese A. Dolecek ◽  
N. Carole Milas ◽  
Linda V. Van Horn ◽  
Marilyn E. Farrand ◽  
Diane D. Gorder ◽  
...  
Keyword(s):  
Risk Factor ◽  
Nutrition Intervention ◽  
Multiple Risk Factor ◽  
Dietary Adherence ◽  
Intervention Trial ◽  
Multiple Risk
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