A history of recurrent spontaneous abortion increases the likelihood of fetal autosomal trisomy at time of genetic amniocentesis

1997 ◽  
Vol 176 (1) ◽  
pp. S94
Author(s):  
M. Adams ◽  
K. Steinhaus ◽  
M. Bocian ◽  
BA. Meyer ◽  
K. Martin
Keyword(s):  
Spontaneous Abortion ◽  
Recurrent Spontaneous Abortion ◽  
Autosomal Trisomy ◽  
Genetic Amniocentesis ◽  
History Of

scholarly journals iTRAQ and PRM-based quantitative proteomics in early recurrent spontaneous abortion: biomarkers discovery

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Ying Cui ◽  
Ling He ◽  
Chun-Yan Yang ◽  
Qian Ye
Keyword(s):  
Spontaneous Abortion ◽  
Early Stage ◽  
Pregnancy Termination ◽  
Diagnostic Value ◽  
Differentially Expressed ◽  
Recurrent Spontaneous Abortion ◽  
Control Group ◽  
Case Group ◽  
Differentially Expressed Proteins ◽  
History Of

Abstract Background Early recurrent spontaneous abortion (ERSA) is a common condition in pregnant women. To prevent ERSA is necessary to look for abortion indicators, such as hormones and proteins, in an early stage. Methods Thirty patients with ERSA were enrolled in the case group. In the control group, we recruited 30 healthy women without a history of miscarriage undergoing voluntary pregnancy termination. The differentially expressed proteins in the serum were identified between the two groups using PRM and iTRAQ. Results Seventy-eight differentially expressed proteins were identified. Using GO functional annotation and KEGG pathway analysis, we detected that the most significant changes occurred in the pathway of Fc gamma R-mediated phagocytosis. Meanwhile, using PRM, we identified three proteins that were closely related to abortion, B4DTF1 (highly similar to PSG1), P11464 (PSG1), and B4DF70 (highly similar to Prdx-2). The levels of B4DTF1 and P11464 were down-regulated, while the level of B4DF70 was up-regulated. Conclusions CD45, PSG1, and Prdx-2, were significantly dysregulated in the samples of ERSA and could become important biomarkers for the prediction and diagnosis of ERSA. Larger‑scale studies are required to confirm the diagnostic value of these biomarkers.

scholarly journals Parental HLA Sharing, Feto-Maternal Compatibility and Neonatal Birthweight in Families With a History of Recurrent Spontaneous Abortion

1993 ◽  
Vol 11 (2-3) ◽  
pp. 125-130 ◽  
Author(s):  
D. C. Kilpatrick ◽  
W. A. Liston
Keyword(s):  
Spontaneous Abortion ◽  
Placental Weight ◽  
Normal Families ◽  
Recurrent Spontaneous Abortion ◽  
Hla Antigen ◽  
History Of ◽  
The Mean ◽  
High Degree ◽  
First Time ◽  
Hla Compatibility

The mean birthweight of babies eventually born to couples with a history of recurrent spontaneous abortion (RSA) is allegedly lower if the parents have a high degree of HLA antigen sharing (Reznikoff-Etievantet al., 1991), but this relationship has not been independently confirmed. We have re-investigated this question by analysing data from 36 families. In 22 instances, we were able to relate birthweight directly to feto-maternal HLA compatibility for the first time in such families. We were unable to confirm any appreciable influence of paternal or feto-maternal HLA sharing on birthweight or placental weight and conclude that RSA families do not differ markedly from normal families in this respect.

scholarly journals Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Jing Yang ◽  
Yan Wang ◽  
Xiao-ye Wang ◽  
Yan-yu Zhao ◽  
Jing Wang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cesarean Section ◽  
Spontaneous Abortion ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
First Trimester ◽  
Recurrent Spontaneous Abortion ◽  
Study Group ◽  
History Of ◽  
Adverse Pregnancy

Although a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of subsequent pregnancy outcome is not clearly elucidated. Here, a retrospective analysis was performed on the clinical data of 492 singleton pregnant women. 164 of them with the history of FRSA were enrolled in study group, compared to 328 deliveries without the history of FRSA. For maternal outcomes, patients in the study group delivered earlier with mean gestational age and the incidences of cesarean section and postpartum hemorrhage were higher compared to the control group. For placental outcomes, the incidence of placenta-mediated pregnancy complications (PMPC) in the study group increased in terms of late-onset preeclampsia, oligohydramnios, early-onset fetal growth restriction, and second-trimester abortion. Patients in the study group were more likely to suffer from placenta accreta, placenta increta, and placenta percreta. For perinatal outcomes, the proportion of birth defects of newborns in the study group was greater. At last, logistic regression analyses showed that the history of FRSA was an independent risk factor for cesarean section and pregnancy complications. In conclusion, women with the history of FRSA are often exposed to an elevated incidence of maternal-placental-perinatal adverse pregnancy outcomes.

Time to pregnancy after pre-gestational allogeneic immunotherapy and peripheral blood cell cytokine profile in women with a history of recurrent spontaneous abortion

2021 ◽  
Vol 1_2021 ◽  
pp. 79-87
Author(s):  
Nikolaeva M.A. Nikolaeva ◽  
Arefieva A.S. Arefieva ◽  
Stepanova E.O. Stepanova E ◽  
Golubeva E.L. Golubeva E ◽  
Vtorushina V.V. Vtorushina V ◽  
...  
Keyword(s):  
Blood Cell ◽  
Spontaneous Abortion ◽  
Peripheral Blood ◽  
Peripheral Blood Cell ◽  
Cytokine Profile ◽  
Recurrent Spontaneous Abortion ◽  
Time To Pregnancy ◽  
History Of
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