T1222 Small Animal PET-CT as a Non-Invasive Method to Evaluate Terminal Ileal Inflammation in a Murine Model of Crohn's Disease

2010 ◽  
Vol 138 (5) ◽  
pp. S-514-S-515 ◽  
Author(s):  
Pieter Hindryckx ◽  
Steven Staelens ◽  
Steven Deleye ◽  
Harald Peeters ◽  
Debby Laukens ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Murine Model ◽  
Small Animal ◽  
Small Animal Pet ◽  
Animal Pet ◽  
Non Invasive ◽  
Pet Ct ◽  
Invasive Method

scholarly journals Suppression of 18F-FDG signal in the bladder on small animal PET-CT

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205610 ◽  
Author(s):  
Lorena Cussó ◽  
Manuel Desco
Keyword(s):  
Small Animal ◽  
Small Animal Pet ◽  
Animal Pet ◽  
Pet Ct ◽  
18F Fdg

Ansprechen auf eine Docetaxel-therapie im LNCaP-Prostata-karzinom-Xenograft-Mausmodell

2013 ◽  
Vol 52 (04) ◽  
pp. 141-147 ◽  
Author(s):  
M. Souvatzoglou ◽  
T. Schuster ◽  
R. Nawroth ◽  
G. Weirich ◽  
U. Treiber ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Line ◽  
Small Animal ◽  
Small Animal Pet ◽  
Control Group ◽  
Choline Uptake ◽  
Animal Pet ◽  
Choline Pet ◽  
Pet Ct ◽  
The Mean

SummaryThe aim of this study was to determine whether [11C]choline can be used for docetaxel therapy response assessment in a LNCaPprostate cancer xenograft mouse model using [11C]choline small-animal PET/CT. Animals, methods: The androgen-dependent human prostate cancer cell line LNCaP was implanted subcutaneously into the left flanks of 17 SCID-mice, 12.5 mg testosterone platelets were implanted in the neck wrinkle. All mice were injected 4–6 weeks after xenograft implantation with 37 MBq [11C]choline via the tail vein. Dynamic imaging was performed for 60 minutes with a small-animal PET/CT scanner. After the first [11C]choline PET/CT imaging 8 mice were subsequently injected intravenously with docetaxel twice (days 1 and 5) at a dose of 3 mg/kg body weight. 8 mice were treated with PBS as a control. [11C]choline PET/CT imaging was performed on day 7, 14 and 21 after treatment. Image analysis was performed using tumor/ muscle (T/M) ratios (ROIT/ROIM = T/M ratio). Results: All LNCaP tumours could be visualized by [11C]choline PET/CT. Before treatment the mean T/M ratio was 2.0 ± 0.2 in the docetaxel-treated group and 1.9 ± 0.2 in the control group (p = 0.837). There was a reduction in the mean [11C]choline uptake after docetaxel treatment of the tumours of the LNCaP cell line as early as 1 week after initiation of therapy (T/Mmean ratio 1.5 ± 0.2 after one week, 1.3 ± 0.2 after 2 weeks and 1.4 ± 0.2 after 3 weeks). There was no decrease in [11C]choline uptake in the control group. Conclusion: Our results show that [11C]choline has the potential for use in the early monitoring of the therapeutic effect of docetaxel in a LNCaP prostate cancer xenograft animal model.

Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT

2011 ◽  
Vol 69 (6) ◽  
pp. 852-857 ◽  
Author(s):  
Martin Walther ◽  
Peter Gebhardt ◽  
Philipp Grosse-Gehling ◽  
Lydia Würbach ◽  
Ingo Irmler ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
In Vivo Imaging ◽  
Small Animal ◽  
Small Animal Pet ◽  
Animal Pet ◽  
Pet Ct

scholarly journals Prototype Small-Animal PET-CT Imaging System for Image-Guided Radiation Therapy

IEEE Access ◽  
2019 ◽  
Vol 7 ◽  
pp. 143207-143216
Author(s):  
Ekaterina Mikhaylova ◽  
Jamison Brooks ◽  
Darren M. Zuro ◽  
Farouk Nouizi ◽  
Maciej Kujawski ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Imaging System ◽  
Small Animal ◽  
Ct Imaging ◽  
Small Animal Pet ◽  
Animal Pet ◽  
Image Guided Radiation Therapy ◽  
Image Guided ◽  
Pet Ct

Design study for the ClearPET/XPAD small animal PET/CT scanner

2007 ◽  
Author(s):  
M. Khodaverdi ◽  
S. Nicol ◽  
J. Loess ◽  
F. Cassol Brunner ◽  
S. Karkar ◽  
...  
Keyword(s):  
Small Animal ◽  
Small Animal Pet ◽  
Ct Scanner ◽  
Design Study ◽  
Animal Pet ◽  
Pet Ct

Comparative Visualization of Tracer Uptake in In Vivo Small Animal PET/CT Imaging of the Carotid Arteries

2013 ◽  
Vol 32 (3pt2) ◽  
pp. 241-250 ◽  
Author(s):  
S. Diepenbrock ◽  
S. Hermann ◽  
M. Schäfers ◽  
M. Kuhlmann ◽  
K. Hinrichs
Keyword(s):  
Carotid Arteries ◽  
Small Animal ◽  
Tracer Uptake ◽  
Ct Imaging ◽  
Small Animal Pet ◽  
Comparative Visualization ◽  
Animal Pet ◽  
Pet Ct
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