scholarly journals Potential Short-Term Cost-Savings in the Management of Diminutive Distal Colorectal Polyps: Data From a ‘Real-Life’ Dutch Cohort

2011 ◽  
Vol 140 (5) ◽  
pp. S-202-S-203
Author(s):  
Mariëlle Bouwens ◽  
Eveline Rondagh ◽  
Brigitte Essers ◽  
Ad Masclee ◽  
Silvia Sanduleanu
2018 ◽  
Vol 60 (3) ◽  
Author(s):  
Bruno Lumbroso ◽  
Marco Rispoli ◽  
M. Cristina Savastano
Keyword(s):  

Author(s):  
A. Seetharaman ◽  
Nitin Patwa ◽  
Simon Lai Koek Wai ◽  
Ahammed Shamir

The evolution of the Internet has revolutionised the sourcing and procurement processes in organisations in every industry. The focus of this paper is to analyse the perception of business users on the factors which impact the usage of eprocurement systems in the biomedical industry. There are four factors identified in this research: i.e. control and compliance, cost savings, process automation, and improvements and transparency. The benefit of achieving process automation is the first biggest factor, followed by the need for control and compliance, and transparency, being the second and third factors respectively. The fourth factor, cost savings, is ignored because the users perceived that cost savings will not be realised in the short term, and the returns from the investment could be a couple of years after the eprocurement system has been fully operational. The research also concludes that the ability to perform business analytics and to strengthen the supply chain are the most important factors in measuring the success in the adoption of e-procurement systems


Computers ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 79
Author(s):  
Henry Clausen ◽  
Gudmund Grov ◽  
David Aspinall

Anomaly-based intrusion detection methods aim to combat the increasing rate of zero-day attacks, however, their success is currently restricted to the detection of high-volume attacks using aggregated traffic features. Recent evaluations show that the current anomaly-based network intrusion detection methods fail to reliably detect remote access attacks. These are smaller in volume and often only stand out when compared to their surroundings. Currently, anomaly methods try to detect access attack events mainly as point anomalies and neglect the context they appear in. We present and examine a contextual bidirectional anomaly model (CBAM) based on deep LSTM-networks that is specifically designed to detect such attacks as contextual network anomalies. The model efficiently learns short-term sequential patterns in network flows as conditional event probabilities. Access attacks frequently break these patterns when exploiting vulnerabilities, and can thus be detected as contextual anomalies. We evaluated CBAM on an assembly of three datasets that provide both representative network access attacks, real-life traffic over a long timespan, and traffic from a real-world red-team attack. We contend that this assembly is closer to a potential deployment environment than current NIDS benchmark datasets. We show that, by building a deep model, we are able to reduce the false positive rate to 0.16% while effectively detecting six out of seven access attacks, which is significantly lower than the operational range of other methods. We further demonstrate that short-term flow structures remain stable over long periods of time, making the CBAM robust against concept drift.


2021 ◽  
pp. 112067212110523
Author(s):  
Martin Stattin ◽  
Anna-Maria Haas ◽  
Daniel Ahmed ◽  
Alexandra Graf ◽  
Katharina Krepler ◽  
...  

Purpose A model was calculated during the first Austrian coronavirus disease-2019 (COVID-19) pandemic lockdown to estimate the effect of a short-term treatment interruption due to healthcare restrictions on visual acuity (VA) in neovascular age-related macular degeneration (nAMD). The model was compared to the real-life outcomes before treatment re-started. Methods Retrospective data-collection of 142 eyes in 142 patients receiving repeated intravitreal injections with anti-VEGF at a retina unit in Vienna in a personalized pro-re-nata regimen prior to the COVID-19 associated lockdown, when treatment was deferred between March 16 and May 4, 2020. During the lockdown, the preliminary data was integrated into pre-existing formulae based on the natural course of the disease in untreated eyes in the long term. Patients were re-scheduled and treated after gradually opening operating rooms. The calculation model was compared to the effective VA change. Results The model calculated an overall VA loss of 3.5 ± 0.8 letters early treatment diabetes retinopathy study (ETDRS) ( p < 0.001 [95% CI:3.3;3.6]) on average compared to 2.5 ± 6 letters ETDRS ( p < 0.001 [95% CI:1.5;3.5]) as measured with a mean treatment delay of 61 ± 14 days after previously scheduled appointments. The total difference between the model exercise and the real-life outcomes accounted for 1 ± 5.9 letters ETDRS ( p = 0.051 [95% CI: 0.1;1.9]). Conclusion The herein presented calculation model might not be suitable to estimate the effective VA loss correctly over time, although untreated eyes and eyes under therapy show similarities after short-term treatment interruption. However, this study demonstrated the potentially negative impact of the COVID-19 pandemic lockdown on patients compromised by nAMD.


ORiON ◽  
2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Petrus Potgieter ◽  
Bronwyn Howell

The non-rival, non-excludable and infinitely expansible characteristics of digital goods with marginal cost of zero strongly favours the use of bundling strategies. Theoretical tractability requires most models in the current literature to make highly stylized assumptions, rarely observed or anticipated in the real-life situations, motivating inquiry. This paper considers a competition model in which: * the firms, consumers and differentiated products are finite in number; * prices are discrete and not continuous; * consumers may purchase multiple items in a single product category where the degree of complementarity or substitutability of the product categories can also vary across consumers; and * where consumer-specific cost savings are obtained when purchasing multiple items from the same firm. Approximate solutions are obtained through numerical simulation. Firms act in concert to maximise the total firm revenue. Our main finding is that the interplay between maximal firm revenue, consumer surplus and prices is very complex and that high firm revenue and high consumer surplus are not antithetic. It suggests also that consumer surplus and market concentration are not necessarily related. Many market outcomes that are observed may be due to chance rather than design as diverse outcomes can accompany situations that are, to the firms, difficult to distinguish.


2020 ◽  
Vol 13 (4) ◽  
pp. 309-323
Author(s):  
Zsolt Sándor

This article presents the anticipated safety effects of the implantation of section control in Hungary. The proposed results were originated from international studies and the local circumstances. Effects are depending on the control coverage and the magnitude of the sanctions. Direct (short term benefits) and indirect effects (long term benefits) can be identified. Direct effects are the decreasing of accident numbers, while indirect effects are the decrease of other externalities of transport like environmental loads. Based on the results the implementation cost of the enforcement system is measureable with the proposed social cost savings come from the decreasing number of accidents.


Author(s):  
A. Seetharaman ◽  
Nitin Patwa ◽  
Simon Lai Koek Wai ◽  
Ahammed Shamir

The evolution of the Internet has revolutionised the sourcing and procurement processes in organisations in every industry. The focus of this paper is to analyse the perception of business users on the factors which impact the usage of eprocurement systems in the biomedical industry. There are four factors identified in this research: i.e. control and compliance, cost savings, process automation, and improvements and transparency. The benefit of achieving process automation is the first biggest factor, followed by the need for control and compliance, and transparency, being the second and third factors respectively. The fourth factor, cost savings, is ignored because the users perceived that cost savings will not be realised in the short term, and the returns from the investment could be a couple of years after the eprocurement system has been fully operational. The research also concludes that the ability to perform business analytics and to strengthen the supply chain are the most important factors in measuring the success in the adoption of e-procurement systems


2020 ◽  
Vol 92 (6) ◽  
pp. 1276-1277 ◽  
Author(s):  
Kenichiro Imai ◽  
Kinichi Hotta ◽  
Sayo Ito ◽  
Yuichiro Yamaguchi ◽  
Yoshihiro Kishida ◽  
...  

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Dana P. Goldman ◽  
Darius N. Lakdawalla ◽  
James R. Baumgardner ◽  
Mark T. Linthicum

AbstractMedical innovation has generated significant gains in health over the past decades, but these advances have been accompanied by rapid growth in healthcare spending. Faced with a growing number of high-cost but high-impact innovations, some have argued to constrain prices for new therapies – especially through global caps on pharmaceutical spending and limits on prices for individual drugs. We show that applying this threshold to past innovations would have limited access to many highly valuable drugs such as statins and anti-retrovirals. We also argue that budget caps violate several important principles of health policy. First, budget caps treat healthcare spending as a consumption good, like going to a movie or buying a meal. However, healthcare spending should be viewed as an investment, whose benefits accrue over many years – much like spending on education. Second, budgetary cost is a poor indicator of value, thereby distorting coverage decisions. Third, affordability arguments often use a short-term horizon, thereby missing that long-term health is society’s ultimate goal. Fourth, assessments of benefit should incorporate not just the immediate clinical benefit to patients, but also long-term health improvements, cost savings, and increased productivity. Fifth, global budget caps arbitrarily anchor spending on the status quo, thereby setting too stringent a threshold for socially-desirable innovation. In sum, a solitary focus on short-term costs can be detrimental to population health in the long-run. When medical treatment decisions are properly viewed as investments, budget caps are not the answer; rather, we need to find mechanisms to encourage spending decisions based on long-term value. Only then can we generate health returns to societal investments, while also encouraging the new research and development necessary to extend the gains of recent decades.


2006 ◽  
Vol 18 (6) ◽  
pp. 326-326
Author(s):  
MG Harris ◽  
C Mihalopoulos ◽  
LP Henry ◽  
SM Harrigan ◽  
SF Farrelly ◽  
...  

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