Tu1301 Helicobacter pylori Associated Gastric Mucosal Changes in High Risk Area of Gastric Cancer, Northwest Iran Prospective Cohort Study With 10 Years Follow Up

2016 ◽  
Vol 150 (4) ◽  
pp. S869
Author(s):  
Alireza Sadjadi ◽  
Alireza Delavari ◽  
Abbas Yazdanbod ◽  
Majid Boreiri ◽  
Masoud Sotoudeh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cohort Study ◽  
High Risk ◽  
Prospective Cohort ◽  
Risk Area ◽  
High Risk Area ◽  
Mucosal Changes ◽  
Gastric Mucosal Changes

scholarly journals Evolutionarily-Related Helicobacter pylori Genotypes and Gastric Intraepithelial Neoplasia in a High-Risk Area of Northern Italy

2020 ◽  
Vol 8 (3) ◽  
pp. 324
Author(s):  
Sonia Toracchio ◽  
Rosario Alberto Caruso ◽  
Silvia Perconti ◽  
Luciana Rigoli ◽  
Enrico Betri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Polymerase Chain Reaction ◽  
Helicobacter Pylori ◽  
High Risk ◽  
Intraepithelial Neoplasia ◽  
Northern Italy ◽  
Chain Reaction ◽  
Risk Area ◽  
High Risk Area ◽  
Polymerase Chain

Helicobacter pylori (Hp) is the major recognized risk factor for non-cardia gastric cancer (GC), but only a fraction of infected subjects develop GC, thus GC risk might reflect other genetic/environmental cofactors and/or differences in virulence among infectious Hp strains. Focusing on a high GC risk area of Northern Italy (Cremona, Lombardy) and using archived paraffin-embedded biopsies, we investigated the associations between the Hp vacA and cagA genotype variants and gastric intraepithelial neoplasia (GIN, 33 cases) versus non-neoplastic gastroduodenal lesions (NNGDLs, 37 cases). The glmM gene and the cagA and vacA (s and m) genotypes were determined by polymerase chain reaction (PCR) and sequencing. Hp was confirmed in 37/37 (100%) NNGDLs and detected in 9/33 GINs (27%), consistently with the well-known Hp loss in GC. CagA was detected in 4/9 Hp-positive GINs and in 29/37 NNGDLs. The vacA s1a and m1 subtypes were more common in GINs than in NNGDLs (6/7 vs. 12/34, p=0.014, for s1a; 7/7 vs. 18/34, p=0.020 for m1), with significant vacA s genotype-specific variance. The GIN-associated vacA s1a sequences clustered together, suggesting that aggressive Hp strains from a unique founder contribute to GC in the high-risk area studied.

Which genotype of Helicobacter pylori—cagA or cagE—Is better associated with gastric Cancer risk? Lessons from an extremely high-risk area in Iran

2020 ◽  
Vol 85 ◽  
pp. 104431 ◽  
Author(s):  
Seyedeh Zahra Bakhti ◽  
Saeid Latifi-Navid ◽  
Shokufe Gholizade Tobnagh ◽  
Kiana Yazdanbod ◽  
Abbas Yazdanbod
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
High Risk ◽  
Cancer Risk ◽  
Gastric Cancer Risk ◽  
Risk Area ◽  
High Risk Area

scholarly journals Gastric cancer occurrence in preneoplastic lesions: A long-term follow-up in a high-risk area in Spain

2010 ◽  
Vol 127 (11) ◽  
pp. 2654-2660 ◽  
Author(s):  
Carlos A. González ◽  
Maria Luisa Pardo ◽  
Juan Maria Ruiz Liso ◽  
Pablo Alonso ◽  
Catalina Bonet ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Preneoplastic Lesions ◽  
Risk Area ◽  
High Risk Area ◽  
Cancer Occurrence ◽  
Long Term Follow Up
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