Tu1806 YOUNG ONSET COLORECTAL CANCER RISK AMONG INDIVIDUALS WITH IRON DEFICIENCY ANEMIA AND HEMATOCHEZIA

2020 ◽  
Vol 158 (6) ◽  
pp. S-1169
Author(s):  
Joshua Demb ◽  
Lin Liu ◽  
Caitlin C. Murphy ◽  
Chyke Doubeni ◽  
Maria Elena Martinez ◽  
...  
2019 ◽  
Author(s):  
M Murzi-Pulgar ◽  
B Cuyàs Espí ◽  
S Bazaga Perez de Rozas ◽  
G Iborra Muñoz ◽  
D González-Juan ◽  
...  

Transfusion ◽  
2017 ◽  
Vol 57 (12) ◽  
pp. 3040-3048 ◽  
Author(s):  
MaríaJesús Laso-Morales ◽  
Carlos Jericó ◽  
Susana Gómez-Ramírez ◽  
Jordi Castellví ◽  
Lorenzo Viso ◽  
...  

Author(s):  
Stanislav Vydyborets ◽  
Artem Andriiaka

Colorectal cancer is an extremely urgent issue in modern medicine. This disease is often complicated by anemia, which has specific pathogenetics mechanisms of development and forms a mutual burden syndrome of diseases in cancer patients. The anemic syndrome is accompanied by the development of tissue hypoxia, which in turn activates the processes of oxidative stress and leads to increased release of biologically active compounds, in particular, biogenic amines. One of these is histamine. Its high concentrations cause spasm of the arterioles, which exacerbates tissue hypoxia. We have examined (n=153) patients with colorectal cancer without anemia, (n=75) patients with colorectal cancer complicated bymalignant tumor anemia, and (n=53) patients with iron deficiency anemia. The content of plasma free serotonin fractions was determined by the fluorometric method proposed by Mikhailychenko B.V., Vydyborets S.V. (1999). The patients with iron deficiency anemia and malignant tumor anemia have shown to have a significant increase in plasma free histamine, compared with the control group and the group of patients with colorectal cancer with out anemia. Plasma free histamine was increasing together with the severity of anemia. The article discusses the feasibility of using the content of plasma free histamine, as an option, to assess the state of compensation of secondary metabolic disorders in iron deficiency anemiaand malignant tumor anemia during treatment and its possible differential diagnostic value.


Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 5172-5172 ◽  
Author(s):  
Chia-Jen Liu ◽  
Kuo-Wei Chen ◽  
Yu-Wen Hu ◽  
Ying-Chung Hong ◽  
Yu-Chung Huang ◽  
...  

Abstract Abstract 5172 Background Iron deficiency anemia (IDA) is a common initial manifestation of gastrointestinal malignancies, but the relationship between chronic IDA and further cancer development is not established. Aims We would like to investigate the cancer risk of chronic IDA over a 10-year period in Taiwan. Methods We enrolled patients with iron deficiency anemia from a nationwide health registry in Taiwan during the period 2000–2009. All patients received at least 2 related examinations and were treated with iron supplement. Since IDA is an initial manifestation of many underlying malignancies, we excluded patients whose cancer developed within 1 year after IDA diagnosis. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of chronic IDA patients to general population. The specific types of cancer were addressed. Results A total of 4, 373 patient with IDA were identified, and 132 (3. 02%) IDA patients developed cancer 1 year after enrollment (SIR 1. 52; 95% confidence interval [CI] 1. 27 – 1. 80, p < 0. 001). The risks of kidney (SIR 5. 47, 95% CI 2. 73 – 9. 78), bladder (SIR 3. 6, 95% CI 1. 64 – 6. 83), liver (SIR 2. 80, 95% CI 1. 82 – 4. 13), and colorectal malignancies (SIR 1. 93, 95% CI 1. 22 – 2. 90) elevated. The risk of hematological malignancies were not increased in current study (SIR 1. 13, 95% CI 0. 31 – 2. 89, p = 0. 758). Conclusions After exclusion of cancer development within the first year, IDA patients still had increased risk of cancer, especially kidney, bladder, liver, and colorectal malignancies. Disclosures: No relevant conflicts of interest to declare.


2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15141-e15141
Author(s):  
Stuthi Perimbeti ◽  
Kevin Ye Hou ◽  
William May Lee ◽  
Erika Correa ◽  
Kathleen Degen ◽  
...  

e15141 Background: The Centers for Disease Control and Prevention has published data on incidence rates of colorectal cancer (CRC) referenced from the U.S. Cancer Statistics Working Group. Using data on admissions from the National Inpatient Sample (NIS) from 1999-2014. Iron deficiency anemia (IDA) is a commonly encountered comorbidity of CRC, particularly in late stage disease and is associated with higher rates of complications. Methods: Adult admissions with a primary diagnosis of CRC and secondary diagnosis of IDA were extracted from the NIS database using ICD-9 codes from 1999-2014 (N = 5,130, weighted N = 25,594). The sample was weighted to approximate the full inpatient population of the U.S. to analyze differences in regional distribution (Northeast, Midwest, South, and West) we assumed a normal distribution of 25% per region and then performed a chi squared analysis. Results: There were more cases of CRC with IDA in the South (38.32%) compared to the Midwest (22.76%), West (20.45%) and Northeast (18.46%) (p = 0.001). In addition, there were higher rates of mortality from CRC with IDA in the South (29.32%) compared to the Midwest (22.87%), West (21.43%) and Northeast (16.37%) (p < 0.0001). Conclusions: Our data demonstrates a correspondence between the prevalence of IDA associated CRC with a greater prevalence and increased risk of mortality in the South relative to other regions in the U.S.Regional differences in prevalence also corresponded to regional differences in mortality. Future research should investigate the factors that explain these regional disparities.


2013 ◽  
Vol 31 (31_suppl) ◽  
pp. 177-177
Author(s):  
Joanne E. Schottinger ◽  
Michael H. Kanter ◽  
Andrea Smith

177 Background: The Institute of Medicine report "To Err is Human" highlighted two vulnerabilities that introduce possible diagnostic errors — information overload and failure to follow up abnormal cases. The Southern California Permanente Regional Safety Net program was instituted to identify, using electonic medical records, instances where these inadvertent outpatient safety lapses may have occurred and intervene before patient harm develops. A centralized regional team catches the omission and intervenes to ensure necessary follow up care, early diagnosis, treatment monitoring, or preventing harmful interactions from medications. Methods: For colorectal cancer detection and prevention, a safety net system was already in place to ensure the prompt evaluation of a positive fecal occult blood screening test with colonoscopy. However, evaluation of late stages of colorectal cancer at presentation revealed that failure to diagnose/follow up signs of iron deficiency anemia or rectal bleeding (often attributed to hemorrhoids) were opportunities to intervene. The electronic medical record is mined for evidence of iron deficiency anemia in laboratory results or a diagnosis of rectal bleeding that was not followed by a colonoscopy in patients aged 50-75. A list of these patients is reviewed quarterly by a gastroenterologist, who contacts the primary care physician to arrange colonoscopy. Results: During the first six months of the program, 42 patients, aged 52-75, underwent colonoscopy for evaluation of either evidence of iron deficiency anemia or rectal bleeding. Polypectomies were performed in 17 patients (40%) with pathology revealing adenomas in 13 patients and one patient with a bleeding carcinoid tumor. Other findings included hyperplastic polyps, hemorrhoids, diverticular disease, colitis, ulcer, and angiodysplastic lesions. Conclusions: Using an electronic medical record system, an outpatient safety net function allows proactive identification of possible safety issues in the population, helping to avoid late stage diagnoses and adverse outcomes. This system currently encompasses other cancer screening tests, medication monitoring, avoiding harmful medication interactions, and immunizations.


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