Sa025 THE IMPACT OF BARIATRIC SURGERY ON COLORECTAL CANCER RISK: A MATCHED ANALYSIS USING A NATIONWIDE U.S. COHORT

Colorectal cancer (CRC) dominants in incidence and mortality among all malignant tumors, it is observed both globally and different regions of Russia. The results of analytical epidemiological study «case-control» on the impact of the colorectal cancer risk factors are presented. Considered risk factors were associated with the sources of water consumption and the some features of diet in Permski Krai. Questionnaire surveys of 200 patients with CRC and 200 healthy individuals were performed. Observation and control groups were spread evenly by sex, age and ethnicity. It was determined following risk factors: consumption of municipal unboiled water and well water, sour cream intake, high concentration of salt in the food, fat, fried and spicy meal as well. There were protective factors such us consumption of municipal boiled water and intake of total dairy products more than 1000 g per week.

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Long-term incidence of colorectal cancer after bariatric surgery or usual care in the Swedish Obese Subjects study

PLoS ONE ◽

10.1371/journal.pone.0248550 ◽

2021 ◽

Vol 16 (3) ◽

pp. e0248550

Author(s):

Magdalena Taube ◽

Markku Peltonen ◽

Kajsa Sjöholm ◽

Richard Palmqvist ◽

Johanna C. Andersson-Assarsson ◽

...

Keyword(s):

Colorectal Cancer ◽

Bariatric Surgery ◽

Rectal Cancer ◽

Cancer Risk ◽

Colorectal Cancer Risk ◽

Control Group ◽

Surgery Group ◽

Obese Subjects

Bariatric surgery in patients with obesity is generally considered to reduce cancer risk in patients with obesity. However, for colorectal cancer some studies report an increased risk with bariatric surgery, whereas others report a decreased risk. These conflicting results demonstrate the need of more long-term studies analyzing the effect of bariatric surgery on colorectal cancer risk. Therefore, data from the Swedish Obese Subjects (SOS) study, ClinicalTrials.gov identifier: NCT01479452, was used to examine the impact of bariatric surgery on long-term incidence of colorectal cancer. The SOS study includes 2007 patients who underwent bariatric surgery and 2040 contemporaneously matched controls who received conventional obesity treatment. Patients in the surgery group underwent gastric bypass (n = 266), banding (n = 376) or vertical banded gastroplasty (n = 1365). Information on colorectal cancer events was obtained from the Swedish National Cancer Registry. Median follow-up was 22.2 years (inter-quartile range 18.3–25.2). During follow up there were 58 colorectal cancer events in the surgery group and 67 colorectal cancer events in the matched control group with a hazard ratio (HR) of 0.79 (95% CI:0.55–1.12; p = 0.183). After adjusting for age, body mass index, alcohol intake, smoking status, and diabetes, the adjusted HR was 0.89 (95% CI:0.62–1.29; p = 0.551). When analyzing rectal cancer events separately- 19 events in the surgery group and 31 events in the control group-a decreased risk of rectal cancer with surgery was observed (HR = 0.56; 95% CI:0.32–0.99; p = 0.045, adjusted HR = 0.61 (95% CI:0.34–1.10; p = 0.099), while the risk of colon cancer was unchanged. To conclude- in this long-term, prospective study, bariatric surgery was not associated with altered colorectal cancer risk.

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Dietary Patterns and Colorectal Cancer Risk

Current Developments in Nutrition ◽

10.1093/cdn/nzaa044_053 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 354-354

Author(s):

Hui Sun ◽

Zhi-gui He ◽

Dong Zhao

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Dietary Patterns ◽

New Technologies ◽

Science And Technology ◽

Intestinal Flora ◽

Colorectal Cancer Risk ◽

Funding Sources ◽

Meta Analyses ◽

The Impact

Abstract Objectives Over the past decade, Multiple systematic reviews and meta- analyses have reported epidemiological associations between colorectal cancer and dietary patterns. while the use of new technologies, such as metabolomics, to analyze the effects of different dietary patterns on metabolites and intestinal flora, can provide further insights into the relationship between diet and cancer risk. In this Review, we summarize the current state of the field to assess the impact of various dietary patterns on colorectal cancer risk. Methods This review mainly adopts the literature research method. The references were collected from PubMed and Web of Science, with colon cancer, colorectal cancer, rectal cancer, Dietary patterns, Mediterranean Dietary patterns (MED), western Dietary patterns (WD), Plant-based Dietary patterns (PBD), Pro-inflammatory Dietary patterns (PID) and Dietary Approaches to Stop Hypertension (DASH) as the key words, and the publications of the last ten years were collected for analysis. Results The impact of different dietary patterns on colorectal cancer risk may depend on family history, gender, age and other lifestyle and intestinal flora factors. But overall, PBD, MED, DASH, and Antioxidant-rich diets (ARD) can reduce colorectal cancer risk. WD, PID, and Hyperinsulinaemic diet (HID) may increase the risk of colorectal cancer. Conclusions Increasing the proportion of whole fruits, grains, vegetables, olive oil, and fish in the diet, and reducing red and processed meats, fine grains, fruit juices, and alcohol intake can reduce the risk of colorectal cancer. Funding Sources This work was supported by Guilin Science and Technology Bureau [Science and Technology Breakthrough Project 20,170,103–4]. Zhi-gui He is the corresponding author.

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