The Effect of Univalent Cation Salts on the Stability and on Certain Physical Properties of Pyruvate Kinase

Under the tuning of an external electric field, the variation of the geometric structures and the band gaps of the wurtzite semiconductors ZnS, ZnO, BeO, AlN, SiC and GaN have been investigated by the first-principles method based on density functional theory. The stability, density of states, band structures and the charge distribution have been analyzed under the electric field along (001) and (00[Formula: see text]) directions. Furthermore, the corresponding results have been compared without the electric field. According to our calculation, we find that the magnitude and the direction of the electric field have a great influence on the electronic structures of the wurtzite materials we mentioned above, which induce a phase transition from semiconductor to metal under a certain electric field. Therefore, we can regulate their physical properties of this type of semiconductor materials by tuning the magnitude and the direction of the electric field.

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Effect of Lactic Acid Content into on during Miconazole Eye Drops to be Used for Infection Preventive

Journal of Drug Research and Development ◽

10.16966/2470-1009.160 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Yoshimura K ◽

Inoue Y ◽

Koizumi A ◽

Suzuki M ◽

Itakura S ◽

...

Keyword(s):

Lactic Acid ◽

Physical Properties ◽

Acid Content ◽

Eye Drops ◽

Lactic Acid Content ◽

The Stability

Purpose: The aims of this study were to prepare a 0.1% Miconazole (MCZ) eye-drop solution and to evaluate the stability and physical properties of the preparation.

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Effect of the Surfactant Concentration on Sinking Electric Discharge Machining Performance with Water-in-Oil Emulsion as Dielectric

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.189-193.3153 ◽

2011 ◽

Vol 189-193 ◽

pp. 3153-3157

Author(s):

Yan Zhen Zhang ◽

Yong Hong Liu ◽

Ren Jie Ji ◽

Bao Ping Cai

Keyword(s):

Physical Properties ◽

Electric Discharge ◽

Surfactant Concentration ◽

Emulsion Stability ◽

Experimental Results ◽

Machining Performance ◽

Electric Discharge Machining ◽

Oil Emulsion ◽

The Stability ◽

Water In Oil Emulsion

In this paper, the EDM performance of water-in-oil (W/O) emulsions dielectric with different surfactant concentration is investigated by correlated to its physical properties, such as viscosity and droplets size, which is predominantly determined by the surfactant concentration. Experimental results show that the stability of the W/O emulsions increases with increasing surfactant concentration, whereas the EDM performance deteriorates with increasing surfactant concentration. So, taking a comprehensively consideration of the emulsion stability and EDM performance, the concentration of surfactant must be appropriately selected.

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In SilicoInvestigation of Potential Pyruvate Kinase M2 Regulators from Traditional Chinese Medicine against Cancers

BioMed Research International ◽

10.1155/2014/189495 ◽

2014 ◽

Vol 2014 ◽

pp. 1-14 ◽

Cited By ~ 1

Author(s):

Kuan-Chung Chen ◽

Kuen-Bao Chen ◽

Hsin-Yi Chen ◽

Calvin Yu-Chian Chen

Keyword(s):

Virtual Screening ◽

Drug Development ◽

Pyruvate Kinase ◽

Md Simulation ◽

Docking Simulation ◽

Target Protein ◽

Binding Affinities ◽

Pyruvate Kinase M2 ◽

Lead Compounds ◽

The Stability

A recent research in cancer research demonstrates that tumor-specific pyruvate kinase M2 (PKM2) plays an important role in chromosome segregation and mitosis progression of tumor cells. To improve the drug development of TCM compounds, we aim to identify potent TCM compounds as lead compounds of PKM2 regulators. PONDR-Fit protocol was utilized to predict the disordered disposition in the binding domain of PKM2 protein before virtual screening as the disordered structure in the protein may cause the side effect and downregulation of the possibility of ligand to bind with target protein. MD simulation was performed to validate the stability of interactions between PKM2 proteins and each ligand after virtual screening. The top TCM compounds, saussureamine C and precatorine, extracted fromLycium chinenseMill. andAbrus precatoriusL., respectively, have higher binding affinities with target protein in docking simulation than control. They have stable H-bonds with residues A:Lys311 and some other residues in both chains of PKM2 protein. Hence, we propose the TCM compounds, saussureamine C and precatorine, as potential candidates as lead compounds for further study in drug development process with the PKM2 protein against cancer.

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Novel approach for overcoming the stability challenges of lipid-based excipients. Part 1: Screening of solid-state and physical properties of polyglycerol esters of fatty acids as advanced pharmaceutical excipients

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2020.01.012 ◽

2020 ◽

Vol 148 ◽

pp. 134-147 ◽

Cited By ~ 2

Author(s):

Carolina Corzo ◽

Diogo Gomes Lopes ◽

Dirk Lochmann ◽

Sebastian Reyer ◽

Michael Stehr ◽

...

Keyword(s):

Fatty Acids ◽

Solid State ◽

Physical Properties ◽

Pharmaceutical Excipients ◽

Novel Approach ◽

The Stability ◽

Polyglycerol Esters

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Kinetochore-microtubule stability governs the metaphase requirement for Eg5

Molecular Biology of the Cell ◽

10.1091/mbc.e14-03-0785 ◽

2014 ◽

Vol 25 (13) ◽

pp. 2051-2060 ◽

Cited By ~ 26

Author(s):

A. Sophia Gayek ◽

Ryoma Ohi

Keyword(s):

Physical Properties ◽

Human Cell ◽

Mitotic Spindle ◽

Mammalian Cells ◽

Human Cell Lines ◽

Bipolar Spindle ◽

Daughter Cells ◽

Microtubule Stability ◽

The Stability ◽

Bipolar Spindles

The mitotic spindle is a bipolar, microtubule (MT)-based cellular machine that segregates the duplicated genome into two daughter cells. The kinesin-5 Eg5 establishes the bipolar geometry of the mitotic spindle, but previous work in mammalian cells suggested that this motor is unimportant for the maintenance of spindle bipolarity. Although it is known that Kif15, a second mitotic kinesin, enforces spindle bipolarity in the absence of Eg5, how Kif15 functions in this capacity and/or whether other biochemical or physical properties of the spindle promote its bipolarity have been poorly studied. Here we report that not all human cell lines can efficiently maintain bipolarity without Eg5, despite their expressing Kif15. We show that the stability of chromosome-attached kinetochore-MTs (K-MTs) is important for bipolar spindle maintenance without Eg5. Cells that efficiently maintain bipolar spindles without Eg5 have more stable K-MTs than those that collapse without Eg5. Consistent with this observation, artificial destabilization of K-MTs promotes spindle collapse without Eg5, whereas stabilizing K-MTs improves bipolar spindle maintenance without Eg5. Our findings suggest that either rapid K-MT turnover pulls poles inward or slow K-MT turnover allows for greater resistance to inward-directed forces.

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From the results of the stability of soil structure studies and the physical characteristics of the black meadow soil of the mountain meadow in the limited national park (gorkhi-terelj national park)

Mongolian Journal of Agricultural Sciences ◽

10.5564/mjas.v22i03.951 ◽

2018 ◽

Vol 22 (03) ◽

pp. 89-95

Author(s):

Lkhamsuren B ◽

Odgerel B ◽

Purevsuren Sh

Keyword(s):

Physical Properties ◽

Vegetation Cover ◽

National Park ◽

Soil Structure ◽

Soil Stabilization ◽

Meadow Soil ◽

Mountain Meadow ◽

Stability And Stabilization ◽

The Stability ◽

Properties Of Soil

The study aims to investigate changes in the physical properties of soil depending on the utilization conditions of the Special Protected National Park compared to the area fenced for more than 10 years. The stability and stabilization of the stabilized mountain meadow soil stabilization and physical properties of soil in the Gorkhi-Terelj National Park (GTNP) resort and limited concentration of tourism. As a result of the study, the stability of the soil structure was 2.8 points in the area of vegetation cover 0-3 cm outside the fence, while the 2.6 layered soil layers above the soils of the vegetation cover. However, the area with vegetation cover within the fence is 4.2 points in soil 0-3 cm and 4 leaves in soil without vegetation cover.

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Φυσικές και χημικές επεξεργασίες οικολογικών κλωστοϋφαντουργικών υλών

10.12681/eadd/30481 ◽

2013 ◽

Author(s):

Γεώργιος Σαββίδης

Keyword(s):

Physical Properties ◽

Cotton Fabrics ◽

Partial Replacement ◽

Synthetic Dyes ◽

Natural Pigments ◽

Colour Measurements ◽

Application Techniques ◽

Digital Textile Printing ◽

Jet Printing ◽

The Stability

Various applications of natural pigments in cotton fabrics were studied.There was a research on the potentials of the plant colorant annatto on the cotton fabrics. Alumwas selected as a mordant. The study focused on the most important application techniques andconditions (temperature, pH, amount of alum) bearing in mind the new environmentalrequirements and the new technological possibilities.The aim was to standardize the whole procedure in order to form a regular protocol for the textiledyeing with natural dyes, thus achieving at least a partial replacement of synthetic dyes bynatural dyes. Quality control of all the dyeing performed was made using standard fastness testsand colour measurements.Another part of the study was the usage of 11 natural pigments for the preparation of printingpastes. The physical properties pH, conductivity, surface tension and viscosity of these pasteswere measured over a period of 16 days for the evaluation of the stability and suitability of themand they proved to be suitable and used for printing of cotton fabrics. The prints were subjectedto wash, light, rub, perspiration, dry clean, dry heat fixation, PVC migration, hypochlorite bleachand discharge fastness tests and colour measurements and they proved, to be satisfactory.The third section of the study involves four natural pigments, which were used as colorants forthe preparation of water-based ink jet inks for digital textile printing. The physical properties ofthe inks were estimated over a period of 90 days and were proved to be stable and suitable forink jet printing. The prints were subjected to wash, light and rub fastness tests and colourmeasurements. The results were promising and this paves the way for the production ofenvironmentally friendly cotton prints through the formulation of suitable printing techniques.

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