368: The Analysis of Vitamin D Receptor and Retinoid X Receptor in Renal Cell Carcinoma

In this meta-analysis, we investigated the association of methylenetetrahydrofolate reductase, vitamin D receptor, and interleukin-16 gene polymorphisms with the risk of renal cell carcinoma. We searched the PubMed and Cochrane Library databases up to July 1, 2017, and included 12 eligible case–control studies in our analysis. The vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype were all associated with the risk of renal cell carcinoma in Asian populations. However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma. Our study indicates that the vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype are associated with renal cell carcinoma risk.

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388: Prognostic Significance of Vitamin D Receptor and Retinoid X-Receptors Expression in Renal Cell Carcinoma

The Journal of Urology ◽

10.1016/s0022-5347(18)32644-2 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 127-127

Author(s):

Wataru Obara ◽

Ryuichiro Kanda ◽

Shuntaro Akasaka ◽

Akira Sugawara ◽

Tomoaki Fujioka

Keyword(s):

Renal Cell Carcinoma ◽

Vitamin D ◽

Cell Carcinoma ◽

Vitamin D Receptor ◽

Renal Cell ◽

Prognostic Significance ◽

Retinoid X Receptors ◽

X Receptors

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Vitamin D receptor suppresses proliferation and metastasis in renal cell carcinoma cell lines via regulating the expression of the epithelial Ca2+ channel TRPV5

PLoS ONE ◽

10.1371/journal.pone.0195844 ◽

2018 ◽

Vol 13 (4) ◽

pp. e0195844 ◽

Cited By ~ 4

Author(s):

YongMing Chen ◽

XinYu Liu ◽

FaBiao Zhang ◽

ShanFan Liao ◽

XiYuan He ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Vitamin D ◽

Cell Carcinoma ◽

Cell Lines ◽

Vitamin D Receptor ◽

Renal Cell ◽

Carcinoma Cell ◽

Renal Cell Carcinoma Cell ◽

Carcinoma Cell Lines ◽

Proliferation And Metastasis

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MiR-125b promotes migration and invasion by targeting the vitamin D receptor in renal cell carcinoma

International Journal of Medical Sciences ◽

10.7150/ijms.49328 ◽

2021 ◽

Vol 18 (1) ◽

pp. 150-156

Author(s):

Xiyuan He ◽

Shangfan Liao ◽

Dongming Lu ◽

Fabiao Zhang ◽

Yingming Sun ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Vitamin D ◽

Cell Carcinoma ◽

Vitamin D Receptor ◽

Renal Cell ◽

Migration And Invasion

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Expression of vitamin D receptor in clear cell papillary renal cell carcinoma

Annals of Diagnostic Pathology ◽

10.1016/j.anndiagpath.2018.06.007 ◽

2018 ◽

Vol 36 ◽

pp. 1-4

Author(s):

Yiqiu Wang ◽

Ying Ding ◽

Chao Qin ◽

Min Gu ◽

Zengjun Wang ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Vitamin D ◽

Cell Carcinoma ◽

Vitamin D Receptor ◽

Renal Cell ◽

Clear Cell ◽

Papillary Renal Cell Carcinoma

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MiR-125b promotes migration and invasion by targeting vitamin D receptor in renal cell carcinoma

10.21203/rs.3.rs-19608/v1 ◽

2020 ◽

Author(s):

XiYuan He ◽

ShangFan Liao ◽

DongMing Lu ◽

FaBiao Zhang ◽

yongyang wu

Keyword(s):

Renal Cell Carcinoma ◽

Vitamin D ◽

Cell Carcinoma ◽

Cell Lines ◽

Vitamin D Receptor ◽

Cell Apoptosis ◽

Renal Cell ◽

Migration And Invasion ◽

Proliferation And Metastasis ◽

And Behavior

Abstract Background To investigate the expression of miR-125b and vitamin D receptor (VDR) in renal cell carcinoma (RCC) and assess the possible association between them. Then, to elucidate whether miR-125b can regulate the expression of VDR and affect proliferation and metastasis in RCC. Methods The expression of miR-125b was detected by quantitative real-time polymerase chain reaction (RT-PCR) in RCC cell lines. MiR-125b mimic and inhibitor were employed to measure the function and behavior of miR-125b in RCC cell lines. The relationship between miR-125 and VDR was verified using luciferase assays, and their expression was also examined in primary tumor and normal peritumoral kidney tissues in 20 clear cell RCC (ccRCC) samples. Results Overexpression of miR-125b promoted migration and invasion and reduced cell apoptosis in ACHN cells, while inhibition of miR-125b suppressed migration and invasion and induced cell apoptosis in 786-O cells. Overexpression of miR-125b decreased VDR expression via targeting VDR. Expression of miR-125b mRNA was significantly higher in ccRCC tissues than in normal adjacent tissues, and the expression of miR-125b mRNA negatively correlated with that of VDR (r=-0.444, p=0.04). Conclusion Overexpression of miR-125b decreased the expression of VDR and the promoted migration and invasion of RCC cells; in addition, there was a negative correlation between miR-125b and VDR expression in ccRCC.

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