Biosynthesis of some sulfur-containing natural products investigations of the mechanism of carbon-sulfur bond formation

Tetrahedron ◽  
1983 ◽  
Vol 39 (8) ◽  
pp. 1215-1238 ◽  
Author(s):  
Ronald J. Parry
Keyword(s):  
Natural Products ◽  
Bond Formation ◽  
Sulfur Containing ◽  
Sulfur Bond

A Review on Thiocyanation of Indoles

2020 ◽  
Vol 17 ◽  
Author(s):  
Chitteti Divyavani ◽  
Pannala Padmaja ◽  
Vinod G. Ugale ◽  
Pedavenkatagari Narayana Reddy
Keyword(s):  
Bond Formation ◽  
Building Blocks ◽  
Biologically Active ◽  
Indole Derivatives ◽  
Pharmacological Activities ◽  
New Methods ◽  
Sulfur Containing ◽  
Biological And Pharmacological Activities ◽  
Sulfur Bond

Background:: The thiocyanation of indoles is a direct way for carbon sulfur bond formation to access 3- thiocyanato-indoles. 3-Thiocyanato-indoles exhibit potent biological and pharmacological activities and also serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives. Objective:: The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on the scope and mechanism. Conclusion:: In this review, we have summarized various methods for the thiocyanation of indoles. Selected new methods for the preparation of 3-thiocyanato-indoles will be highlighted. The mechanistic aspects and significance of the methods are briefly discussed.

Formation of Carbon-Oxygen Bond Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions

2020 ◽  
Vol 17 ◽  
Author(s):  
Ayesha Jalil ◽  
Yaxin O Yang ◽  
Zhendong Chen ◽  
Rongxuan Jia ◽  
Tianhao Bi ◽  
...  
Keyword(s):  
Natural Products ◽  
Bond Formation ◽  
Building Blocks ◽  
Review Article ◽  
Hypervalent Iodine ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
The Past ◽  
Oxygen Bond ◽  
Privileged Scaffolds

: Hypervalent iodine reagents are a class of non-metallic oxidants have been widely used in the construction of several sorts of bond formations. This surging interest in hypervalent iodine reagents is essentially due to their very useful oxidizing properties, combined with their benign environmental character and commercial availability from the past few decades ago. Furthermore, these hypervalent iodine reagents have been used in the construction of many significant building blocks and privileged scaffolds of bioactive natural products. The purpose of writing this review article is to explore all the transformations in which carbon-oxygen bond formation occurred by using hypervalent iodine reagents under metal-free conditions

scholarly journals Lewis acid / Base-free Strategy for the Synthesis of 2-Arylthio and Selenyl Benzothiazole / Thiazole and Imidazole

2021 ◽  
Vol 27 (1) ◽  
pp. 17-23
Author(s):  
Guniganti Balakishan ◽  
Gullapalli Kumaraswamy ◽  
Vykunthapu Narayanarao ◽  
Pagilla Shankaraiah
Keyword(s):  
Lewis Acid ◽  
Bond Formation ◽  
Acid Base ◽  
Mechanistic Pathway ◽  
Wide Range ◽  
Acid And Base ◽  
Lewis Acid And Base ◽  
Sulfur Bond

Abstract A Cu(II)-catalyzed Csp2-Se and Csp2-Sulfur bond formation was achieved with moderate to good yields without the aid of Lewis acid and base. The reaction is compatible with a wide range of heterocycles such as benzothiazole, thiazole, and imidazole. Also, this typical protocol is found to be active in thio-selenation via S-H activation. Additionally, we proposed a plausible mechanistic pathway involving Cu(III) putative intermediate.

scholarly journals Chemical Investigations Into the Biosynthesis of the Gymnastatin and Dankastatin Alkaloids

2021 ◽  
Author(s):  
Bingqi Tong ◽  
Bridget Belcher ◽  
Daniel Nomura ◽  
Thomas Maimone
Keyword(s):  
Natural Products ◽  
Protein Function ◽  
Bond Formation ◽  
Covalent Bond ◽  
Fungal Strain ◽  
Fertile Ground ◽  
Covalent Bond Formation

Electrophilic natural products have provided fertile ground for understanding how nature inhibits protein function using covalent bond formation. The fungal strain Gymnascella dankaliensis has provided an especially interesting collection of...

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