A novel, one-pot preparation ofN-methyl-α-amino acid dipeptides from oxazolidinones and amino acids

1999 ◽  
Vol 40 (3) ◽  
pp. 467-470 ◽  
Author(s):  
R.L. Dorow ◽  
Diane E. Gingrich
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
One Pot

A facile one pot route for the synthesis of imide tethered peptidomimetics

2016 ◽  
Vol 14 (2) ◽  
pp. 556-563 ◽  
Author(s):  
Veladi Panduranga ◽  
Girish Prabhu ◽  
Roopesh Kumar ◽  
Basavaprabhu Basavaprabhu ◽  
Vommina V. Sureshbabu
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Efficient Method ◽  
One Pot ◽  
Protected Amino Acid

A simple and efficient method for the synthesis of N,N’-orthogonally protected imide tethered peptidomimetics is presented. The imide peptidomimetics were synthesized by coupling the in situ generated selenocarboxylate of Nα-protected amino acids with Nα-protected amino acid azides in good yields.

scholarly journals Biocatalytic stereoinversion ofd-para-bromophenylalanine in a one-pot three-enzyme reaction

2017 ◽  
Vol 19 (2) ◽  
pp. 503-510 ◽  
Author(s):  
Fahimeh Khorsand ◽  
Cormac D. Murphy ◽  
Andrew J. Whitehead ◽  
Paul C. Engel
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Enzyme Reaction ◽  
One Pot ◽  
Phenylalanine Dehydrogenase

d-Amino acid transaminase plus mutant phenylalanine dehydrogenase offer an effective one-pot system for 100% conversion ofdl-amino acids to thel-form.

Microwave-assisted one pot-synthesis of amino acid ionic liquids in water: simple catalysts for styrene carbonate synthesis under atmospheric pressure of CO2

2014 ◽  
Vol 4 (4) ◽  
pp. 963-970 ◽  
Author(s):  
Kuruppathparambil Roshith Roshan ◽  
Tharun Jose ◽  
Dongwoo Kim ◽  
Kathalikkattil Amal Cherian ◽  
Dae Won Park
Keyword(s):  
Amino Acids ◽  
Ionic Liquids ◽  
Amino Acid ◽  
Atmospheric Pressure ◽  
Microwave Energy ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Styrene Carbonate

A novel variety of ionic liquids based on amino acids is synthesized in water using microwave energy.

scholarly journals One-Pot Ring-Opening Peptide Synthesis Using α,α-Difluoro-β-Lactams

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3657-3666 ◽  
Author(s):  
Masaaki Omote ◽  
Atsushi Tarui ◽  
Masakazu Ueo ◽  
Marino Morikawa ◽  
Masahiko Tsuta ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Ester ◽  
Peptide Synthesis ◽  
Ring Opening ◽  
Reactive Intermediates ◽  
One Pot ◽  
Open Chain ◽  
Lactam Ring

α,α-Difluoro-β-lactams successfully underwent ring-opening aminolysis with various amino acids in 2,2,2-trifluoroethanol to afford fluorine-containing peptides. In this aminolysis, it was found that 2,2,2-trifluoroethanol first attacked the α,α-difluoro-β-lactams with cleavage of lactam ring to form the corresponding open-chain 2,2,2-trifluoroethyl esters as reactive intermediates. The trifluoroethyl esters were more electrophilic compared with the corresponding methyl ester and thereby accelerated the aminolysis with various amino acids to form β-amino acid peptides with α,α-difluoromethylene unit.

One-pot synthesis of β-amino acid derivatives from α-amino acids

2006 ◽  
Vol 47 (49) ◽  
pp. 8757-8760 ◽  
Author(s):  
Carlos J. Saavedra ◽  
Rosendo Hernández ◽  
Alicia Boto ◽  
Eleuterio Álvarez
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
One Pot Synthesis

Straightforward Synthesis of Succinimide-Fused Pyrrolizidines by A Three-Component Reaction of α-Diketone, Amino Acid, and Maleimide

Synthesis ◽  
2020 ◽  
Author(s):  
Hua Zhao ◽  
Hongbin Zhai ◽  
Peng Shen ◽  
Yeting Guo ◽  
Jian Wei ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Functional Group ◽  
High Efficiency ◽  
Cycloaddition Reaction ◽  
Azomethine Ylide ◽  
High Yield ◽  
One Pot ◽  
Keto Ester ◽  
Three Component Reaction

AbstractAn efficient, one-pot, three-component [3+2] cycloaddition reaction of azomethine ylide obtained from α-dicarbonyl compounds (cyclic and acyclic diketone or keto ester) and amino acids with maleimides under catalyst-free conditions has been developed. This cascade protocol shows high efficiency and remarkable functional group tolerance, and the ubiquitous succinimide-fused pyrrolizidines with a highly compact and strained scaffold were obtained with high yield and excellent diastereoselectivity. Furthermore, this novel and atom-economical strategy could be performed on a gram scale with comparable reaction efficiency.

One-Pot Synthesis of β-Amino Acid Derivatives from α-Amino Acids.

ChemInform ◽  
2007 ◽  
Vol 38 (13) ◽  
Author(s):  
Carlos J. Saavedra ◽  
Rosendo Hernandez ◽  
Alicia Boto ◽  
Eleuterio Alvarez
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals Asymmetric synthesis of quaternary aryl amino acid derivatives via a three-component aryne coupling reaction

2011 ◽  
Vol 7 ◽  
pp. 1570-1576 ◽  
Author(s):  
Elizabeth P Jones ◽  
Peter Jones ◽  
Andrew J P White ◽  
Anthony G M Barrett
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Coupling Reaction ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
Aryl Group ◽  
Hydrolysis Of

A method was developed for the synthesis of α-alkyl, α-aryl-bislactim ethers in good to excellent yields and high diastereoselectivities, consisting of a facile one-pot procedure in which the aryl group is introduced by means of a nucleophilic addition to benzyne and the alkyl group by alkylation of a resultant benzylic anion. Hydrolysis of the sterically less hindered adducts gave the corresponding quaternary amino acids with no racemization, whereas hydrolytic ring opening gave the corresponding valine dipeptides from bulkier bislactims.

Stereoselective syntheses of α-amino acid and peptide derivatives by the U-4CR of 5-desoxy-5-thio-D-xylopyranosylamine

2001 ◽  
Vol 79 (12) ◽  
pp. 1934-1939 ◽  
Author(s):  
Günther Ross ◽  
Ivar Ugi
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
Chiral Amine ◽  
Peptide Derivatives ◽  
Stereoselective Syntheses

Since 1961, the synthesis of α-amino acids derivatives by the four-component reaction of isocyanides (U-4CR) as a one-pot reaction has been developed. Only recently it was found that a variety of these α-amino acids compounds can be formed stereoselectively by the U-4CR using 1-amino-5-deoxy-5-thio-2,3,4-tri-O-isobutanoyl-β-D-xylopyranose as the amine component. The stereoselectivity inducing auxiliary 5-desoxy-5-thio-D-xylopyranosyl group of the so-formed products can be replaced selectively by hydrogen.Key words: stereoselective U-4CR, chiral amine component, amino carbohydrate, α-amino acid derivatives.

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