6 Molecularly Imprinted Polymers—Preparation, Biomedical Applications and Technical Challenges

Background: Molecularly Imprinted Polymers (MIPs), a type of biomimetic materials have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favorable specificity and selectivity for target analytes, and long shelf life. These materials are able to mimic natural recognition entities, including biological receptors and antibodies, providing a versatile platform to achieve the desirable functionality for various biomedical applications. Objective: In this review article, we introduce the most recent development of MIPs to date. We first highlight the advantages of using MIPs for a broad range of biomedical applications. We then review their various methods of synthesis along with their latest progress in biomedical applications, including biosensing, drug delivery, cell imaging and drug discovery. Lastly, the existing challenges and future perspectives of MIPs for biomedical applications are briefly discussed. Conclusion: We envision that MIPs may be used as potential materials for diverse biomedical applications in the near future.

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Recognition and Absorption of the Water-soluble X-ray Contrast Medium Iodixanol using Molecularly Imprinted Polymers for Biomedical Applications

MRS Proceedings ◽

10.1557/proc-1138-ff09-13 ◽

2008 ◽

Vol 1138 ◽

Cited By ~ 2

Author(s):

Zhan Liu ◽

David G. Bucknall ◽

Mark G. Allen

Keyword(s):

Contrast Medium ◽

Molecularly Imprinted Polymers ◽

Biomedical Applications ◽

Crosslink Density ◽

Binding Capacity ◽

Water Soluble ◽

Spectrometric Analysis ◽

Molecularly Imprinted ◽

Imprinted Polymers ◽

X Ray

AbstractThis work presents the study on the recognition and absorption of the water-soluble X-ray contrast medium iodixanol in aqueous solution using synthetic molecularly imprinted polymers (MIPs). A non-covalent imprinting technique was applied to prepare iodixanol-imprinted polymers using 4-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The effects of quantity of iodixanol templates, the crosslink density, and the solvent were studied in terms of the binding capacity and imprint effect of the polymers. UV-vis spectrometric analysis shows that the highest binding capacity achieved is 284 mg iodixanol per gram of dry polymer, which is 8.8 times higher than the binding capacity of the non-imprinted control polymers (NIPs). SEM and BET surface analysis have also been performed to investigate the effect of morphology and porosity on the binding capacities of polymers.

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Quantum and carbon dots conjugated molecularly imprinted polymers as advanced nanomaterials for selective recognition of analytes in environmental, food and biomedical applications

TrAC Trends in Analytical Chemistry ◽

10.1016/j.trac.2021.116306 ◽

2021 ◽

pp. 116306

Author(s):

Monika Sobiech ◽

Piotr Luliński ◽

Piotr Paweł Wieczorek ◽

Mariusz Marć

Keyword(s):

Molecularly Imprinted Polymers ◽

Carbon Dots ◽

Biomedical Applications ◽

Selective Recognition ◽

Molecularly Imprinted ◽

Imprinted Polymers

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Molecularly Imprinted Polymers (PIMs) in Biomedical Applications

Biopolymers ◽

10.5772/10278 ◽

2010 ◽

Cited By ~ 7

Author(s):

Francesco Puoci ◽

Giuseppe ◽

Manuela Curcio ◽

Francesca Iemma ◽

Ortensia Ilaria Parisi ◽

...

Keyword(s):

Molecularly Imprinted Polymers ◽

Biomedical Applications ◽

Molecularly Imprinted ◽

Imprinted Polymers

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Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review

Molecules ◽

10.3390/molecules26206233 ◽

2021 ◽

Vol 26 (20) ◽

pp. 6233

Author(s):

Abbas J. Kadhem ◽

Guillermina J. Gentile ◽

Maria M. Fidalgo de Cortalezzi

Keyword(s):

Molecularly Imprinted Polymers ◽

Biomedical Applications ◽

Molecular Imprinted Polymers ◽

Molecularly Imprinted ◽

Imprinted Polymers ◽

Signaling Mechanisms ◽

Sensing Platforms ◽

Custom Made ◽

Academic Laboratory ◽

Biomedical Fields

Molecular imprinted polymers are custom made materials with specific recognition sites for a target molecule. Their specificity and the variety of materials and physical shapes in which they can be fabricated make them ideal components for sensing platforms. Despite their excellent properties, MIP-based sensors have rarely left the academic laboratory environment. This work presents a comprehensive review of recent reports in the environmental and biomedical fields, with a focus on electrochemical and optical signaling mechanisms. The discussion aims to identify knowledge gaps that hinder the translation of MIP-based technology from research laboratories to commercialization.

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