scholarly journals Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6233
Author(s):  
Abbas J. Kadhem ◽  
Guillermina J. Gentile ◽  
Maria M. Fidalgo de Cortalezzi
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Biomedical Applications ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Signaling Mechanisms ◽  
Sensing Platforms ◽  
Custom Made ◽  
Academic Laboratory ◽  
Biomedical Fields

Molecular imprinted polymers are custom made materials with specific recognition sites for a target molecule. Their specificity and the variety of materials and physical shapes in which they can be fabricated make them ideal components for sensing platforms. Despite their excellent properties, MIP-based sensors have rarely left the academic laboratory environment. This work presents a comprehensive review of recent reports in the environmental and biomedical fields, with a focus on electrochemical and optical signaling mechanisms. The discussion aims to identify knowledge gaps that hinder the translation of MIP-based technology from research laboratories to commercialization.

Removal of trace contaminants using molecularly imprinted polymers

2006 ◽  
Vol 53 (11) ◽  
pp. 205-212 ◽  
Author(s):  
M. Le Noir ◽  
B. Guieysse ◽  
B. Mattiasson
Keyword(s):  
Activated Carbon ◽  
Molecularly Imprinted Polymers ◽  
The Other ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Trace Contaminants ◽  
High Concentrations ◽  
Trace Concentrations ◽  
Granulated Activated Carbon

This work was conducted to study the potential of molecularly imprinted polymers (MIPs) for the removal of oestradiol at trace concentrations (1 ppm–1 ppb). An MIP synthesised with 17β-oestradiol as template was compared to non-imprinted polymers (NIP) synthesised under the same conditions but without template, a commercial C18 extraction phase and granulated activated carbon. At 1 ppb oestradiol was recovered by 98±2% when using the MIP, compared to 90±1, 79±1, and 84±2% when using the NIP, a C18 phase, or granulated activated carbon, respectively. According to these levels, the MIP was capable of producing an effluent with a quality 5–10 times higher than the other materials. The same levels of oestradiol recovery were achieved with the MIP when supplying 17β-oestradiol at 0.1 ppm. Phenolic compounds added as interferences bound less to the MIP than to the NIP, confirming the selectivity of the MIP. Oestradiol biodegradation was also demonstrated at high concentrations (50 ppm), showing the pollutants can be safely destructed after being enriched by molecular extraction. This study demonstrates the potential of molecular imprinted polymers as a highly efficient specific adsorbent for the removal of trace contaminants.

scholarly journals Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Katarzyna Kwaśniewska ◽  
Renata Gadzała-Kopciuch ◽  
Bogusław Buszewski
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Medical Diagnostics ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Isolation And Purification ◽  
Imprinted Polymers ◽  
Biological And Environmental Samples ◽  
Magnetite Particles ◽  
Interesting Alternative

AbstractTechnology of molecularly imprinted polymers (MIP) has become very popular in recent decades. MIPs are primarily used in medical diagnostics, chromatographic separation and solid phase extraction (SPE); also as sensors and catalysts. In recent years there have been reported benefits of combining molecular imprinted polymers with additional features, e.g. magnetic properties, through the build-up of this type of material on magnetite particles (Magnetic Molecularly Imprinted Polymer – MMIP). This method produces a multifunctional material which has high selectivity and the ability to isolate the analyte from biological and environmental samples, allowing effective purification from such interferents as proteins and fats. This developing branch of new materials for the preparation and purification of complex sample matrices is an interesting alternative to materials routinely used to date, particularly with regard to the immunosorbents. This paper summarizes recent reports regarding MMIP preparation and their application for purification and isolation of compounds from biological matrices.

Progress in Molecularly Imprinted Polymers for Biomedical Applications

2019 ◽  
Vol 22 (2) ◽  
pp. 78-88 ◽  
Author(s):  
Jane Ru Choi ◽  
Kar Wey Yong ◽  
Jean Yu Choi ◽  
Alistair C. Cowie
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Review Article ◽  
Future Perspectives ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Target Analytes ◽  
Methods Of Synthesis ◽  
Near Future

Background: Molecularly Imprinted Polymers (MIPs), a type of biomimetic materials have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favorable specificity and selectivity for target analytes, and long shelf life. These materials are able to mimic natural recognition entities, including biological receptors and antibodies, providing a versatile platform to achieve the desirable functionality for various biomedical applications. Objective: In this review article, we introduce the most recent development of MIPs to date. We first highlight the advantages of using MIPs for a broad range of biomedical applications. We then review their various methods of synthesis along with their latest progress in biomedical applications, including biosensing, drug delivery, cell imaging and drug discovery. Lastly, the existing challenges and future perspectives of MIPs for biomedical applications are briefly discussed. Conclusion: We envision that MIPs may be used as potential materials for diverse biomedical applications in the near future.

Recognition and Absorption of the Water-soluble X-ray Contrast Medium Iodixanol using Molecularly Imprinted Polymers for Biomedical Applications

2008 ◽  
Vol 1138 ◽  
Author(s):  
Zhan Liu ◽  
David G. Bucknall ◽  
Mark G. Allen
Keyword(s):  
Contrast Medium ◽  
Molecularly Imprinted Polymers ◽  
Biomedical Applications ◽  
Crosslink Density ◽  
Binding Capacity ◽  
Water Soluble ◽  
Spectrometric Analysis ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
X Ray

AbstractThis work presents the study on the recognition and absorption of the water-soluble X-ray contrast medium iodixanol in aqueous solution using synthetic molecularly imprinted polymers (MIPs). A non-covalent imprinting technique was applied to prepare iodixanol-imprinted polymers using 4-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The effects of quantity of iodixanol templates, the crosslink density, and the solvent were studied in terms of the binding capacity and imprint effect of the polymers. UV-vis spectrometric analysis shows that the highest binding capacity achieved is 284 mg iodixanol per gram of dry polymer, which is 8.8 times higher than the binding capacity of the non-imprinted control polymers (NIPs). SEM and BET surface analysis have also been performed to investigate the effect of morphology and porosity on the binding capacities of polymers.

Rapid microwave-assisted distillation–precipitation polymerization for the synthesis of magnetic molecular imprinted polymers coupled to HPTLC determination of perphenazine in human urine

2019 ◽  
Vol 43 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Mehdi Safdarian ◽  
Zahra Ramezani
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Atmospheric Pressure ◽  
Precipitation Polymerization ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymers ◽  
Distillation Precipitation Polymerization ◽  
Microwave Assisted

Microwave-assisted distillation–precipitation polymerization (MWDPP) for the synthesis of magnetic molecularly imprinted polymers (MMIPs) under atmospheric pressure is reported.

A Novel Method for Prepairing Higher Performance Picroside I Surface Molecularly Imprinted Polymers for TCM Research

2013 ◽  
Vol 785-786 ◽  
pp. 642-645
Author(s):  
Qing Shan Liu ◽  
Ke Qin Li ◽  
Jun Li ◽  
Xiao Ying Yin ◽  
Tian Hua Yan
Keyword(s):  
Electron Microscope ◽  
Molecularly Imprinted Polymers ◽  
Template Molecule ◽  
Functional Monomer ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Scatchard Equation ◽  
Novel Method ◽  
Scanning Electron

To establish a novel method for preparing molecularly imprinted polymers for Picroside I with better performance on TCM research contrast to previous studies, we have prepared novel surface molecular imprinted polymers (S-MIPs) using Picroside I as the template molecule, Acrylamide (AM) as the functional monomer, and silica gel as the carrier. The morphology of S-MIPs was characterized by scanning electron microscope (SEM) and its static adsorption capacity was measured by the Scatchard equation.

A Novel Method for Preparing the Surface Molecularly Imprinted Polymers to Target Isolate Ginsenoside Rg1 and its Analogues

2012 ◽  
Vol 535-537 ◽  
pp. 2400-2403 ◽  
Author(s):  
Qing Shan Liu ◽  
Li Na Yi ◽  
Qiu Juan Wang ◽  
Qing Long Guo ◽  
Yi Fan Jiang ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Template Molecule ◽  
Functional Monomer ◽  
Ginsenoside Rg1 ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Scatchard Equation ◽  
Novel Method ◽  
Scanning Electron

To establish a novel method for preparing molecularly imprinted polymers for ginsenoside Rg1 with better character contrast to previous studies, we have prepared novel surface molecular imprinted polymers (S-MIPs) using ginsenoside Rg1 as the template molecule, Acrylamide (AM) as the functional monomer, and silica gel as the carrier. The morphology of S-MIPs was characterized by scanning electron microscope (SEM) and its static adsorption capacity was measured by the Scatchard equation.

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