Food-pollen cross-reactivity in oral allergy syndrome and rhinitis

2003 ◽  
Vol 111 (2) ◽  
pp. S103
Author(s):  
F. Marcucci ◽  
G.W. Canonica ◽  
F. Frati ◽  
L. Sensi ◽  
A. Riccio ◽  
...  
Keyword(s):  
Cross Reactivity ◽  
Oral Allergy Syndrome

scholarly journals Sublingual Reactivity to rBET V1 and rPHL P1 in Patients with Oral Allergy Syndrome

2006 ◽  
Vol 19 (1) ◽  
pp. 205873920601900 ◽  
Author(s):  
F. Marcucci ◽  
L. Sensi ◽  
G. DI Cara ◽  
G. Gidaro ◽  
C. Incorvaia ◽  
...  
Keyword(s):  
Specific Ige ◽  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Control Group ◽  
Recombinant Allergens ◽  
Natural Extracts ◽  
Target Organs ◽  
High Concentrations

Oral Allergy Syndrome (OAS) in patients with pollen-induced rhinoconjunctivitis is caused by specific IgE recognizing cross-reacting epitopes of fruits and plants, which were clearly shown in vitro, but failed to be demonstrated in vivo by cross-challenges in the target organs. Considering the hypothesis of degradation of such epitopes in natural extracts, challenges with recombinant pollen allergens were done to evaluate the reactivity of the oral mucosa in OAS patients. Seventeen patients with OAS and rhinitis from birch (10) and grass pollen (7) and 10 non-atopic controls were studied by skin prick tests (SPT), allergen specific nasal challenges (ASNC) and allergen specific sublingual challenges (ASSC) with birch and timothy extracts and with rBet v1 and rPhl p1 at increasing concentrations from 1 to 1000 mcg/ml. None of the healthy subjects in the control group had any positive test for birch and timothy extracts or for recombinant allergens. In the OAS group the following results were observed: SPTs with recombinant allergens were positive in all patients, mostly at 10 mcg/ml concentration; ASNC with rBet v1 were positive in all patients, mostly at 100 mcg/ml; ASSC with natural pollen extracts were positive in only 2 of 17 patients, but in 15 of 17 with rBet v1 and rPhl p1, mostly at 500 mcg/ml and 1000 mcg/ml. ASSC with rBet v1 and rPhl p1 were positive with a mean concentration of 677 and 533 mcg/ml, respectively. The results of sublingual challenges with rBet v1 and rPhl p1 showed the in vivo cross-reactivity between pollens and foods in patients with OAS, but high concentrations of the recombinant allergens were needed to reproduce oral symptoms, thus explaining the failure of challenges performed with natural extracts, which have concentrations of major allergens lower than 50 mcg/ml. This indicates that sublingual mucosa is much less reactive to allergens than other surfaces, such as skin and nasal mucosa, probably because of its anatomic and immunologic peculiarity.

Evaluation of food-pollen cross-reactivity by nose-mouth cross-challenge in pollinosis with oral allergy syndrome

Allergy ◽  
2005 ◽  
Vol 60 (4) ◽  
pp. 501-505 ◽  
Author(s):  
F. Marcucci ◽  
F. Frati ◽  
L. Sensi ◽  
G. D. Cara ◽  
E. Novembre ◽  
...  
Keyword(s):  
Cross Reactivity ◽  
Oral Allergy Syndrome

scholarly journals Oral allergy syndrome in children with pollen sensitization in Tomsk region

2016 ◽  
Vol 13 (6) ◽  
pp. 58-62
Author(s):  
M M Fedotova ◽  
O S Fedorova ◽  
L M Ogorodova ◽  
T A Evdokimova
Keyword(s):  
Skin Prick Testing ◽  
Clinical Stage ◽  
Specific Ige ◽  
Cross Sectional Study ◽  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Pollen Allergens ◽  
Cross Sectional ◽  
Bet V 1 ◽  
Tomsk Region

Background. Oral allergy syndrome (OAS) is defined as immediate IgE-mediated allergic reaction localized in the oral mucosa and developing after consuming raw fruits, vegetables, nuts, legumes in pollen sensitized patients. Objective. To study the prevalence of OAS in children in the Tomsk region. Material. The cross-sectional study in random groups of primary schoolchildren aged 7-10 years (n=13 010) from the Tomsk region, Russia, was performed in frames of (EuroPrevall, № FP6-2006-TTC-TU-5 Proposal 045879). During the screening phase a survey with standardized questionnaire was carried out. Clinical stage (n=1288) included clinical interviewing with parents/guardians, the clinical examination of patients, skin prick testing with extracts of food and pollen allergens (ALK-Abello, Spain), measurement of specific IgE level in serum to food and pollen allergens, component resolved diagnostics (ImmunoCAP, Phadia, Sweden). Results. OAS registered in 13,71% of children with pollen sensitization. The main triggers were apples, carrots, peaches, peanuts. Main cause of OAS in the Tomsk region was cross-reactivity to Bet v 1 - homologues belonging to PR-10 family: to apple - Mal d 1 (r=0,92; p=0,01); to peach - Pru p1 (r=0,87; p=0,01); to peanut - Ara h 8 (r=0,74; p=0,01); to hazelnut - Cor a 1 (r=0,76; p=0,01); to carrot - Dau c 1 (r=0,54; p=0,01). Conclusion. OAS was observed in 13,71% of children with pollen sensitization and was developesed due to crossreactivity to the birch allergen Bet v 1.

Cross Reactivity in Mountain Cedar-Tomato Oral Allergy Syndrome

2007 ◽  
Vol 119 (1) ◽  
pp. S113
Author(s):  
R.S. Bonds ◽  
R. Tiwari ◽  
B. Ning ◽  
E.W. Czerwinski ◽  
R.G. Goldblum ◽  
...  
Keyword(s):  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Mountain Cedar

scholarly journals Crossreactive allergen-specific IgE in children with birch pollen allergic rhinitis

2017 ◽  
Vol 14 (2) ◽  
pp. 66-70
Author(s):  
P V Samoylikov ◽  
S A Mazurina ◽  
P I Gushchin ◽  
V B Gervazieva
Keyword(s):  
Allergic Rhinitis ◽  
Birch Pollen ◽  
Humoral Response ◽  
Specific Ige ◽  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Food Allergens ◽  
Homologous Proteins ◽  
Total Ige ◽  
Bet V 1

Objective. The aim of this study was to research a sIgE allergen profile of birch pollen and to evaluate a contribution of some homologous food allergens as well as latex allergen to the development of sensibility in allergic rhinitis (AR) / rhinoconjunctivitis patients, in focus of cross-reactivity and oral allergy syndrome.. Methods. Blood sera of 21 AR/rhinoconjunctivitis patients (at the age of 3 to 16) and 20 healthy persons without allergy symptoms were used. sIgE to birch pollen, soybean, latex, apple and celery as well as the total IgE levels were measured by the ImmunoCAP method (Phadia, Sweden) and the ELISA kits (Alkorbio, Russia). Results. We detected high total IgE levels, sIgE to allergens of birch pollen, apple, celery, as well as to recombinant allergens of birch Bet v 1, Bet v 2 and soybean - Gly m 4 in AR patients. Correlation analysis of IgE humoral response to homologous proteins showed the direct valid dependence between the sIgE levels to birch isoallergen Bet v 1 and soy isoallergen Gly m 4 (r=0,84; p

Allergenic cross-reactivity among peach, apricot, plum, and cherry in patients with oral allergy syndrome: An in vivo and in vitro study

1994 ◽  
Vol 94 (4) ◽  
pp. 699-707 ◽  
Author(s):  
Elide A. Pastorello ◽  
Claudio Ortolani ◽  
Laura Farioli ◽  
Valerio Pravettoni ◽  
Marco Ispano ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Cross Reactivity ◽  
Vitro Study ◽  
Oral Allergy Syndrome

scholarly journals Purification and Characterization of Pathogenesis Related Class 10 Panallergens

Foods ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 609 ◽  
Author(s):  
Jane K. McBride ◽  
Hsiaopo Cheng ◽  
Soheila J. Maleki ◽  
Barry K. Hurlburt
Keyword(s):  
Immunoglobulin E ◽  
Birch Pollen ◽  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Universal Method ◽  
Purification Method ◽  
Variable Binding ◽  
Pathogenesis Related ◽  
Immunocap Isac

Oral allergy syndrome (OAS) describes an allergic reaction where an individual sensitized by pollen allergens develops symptoms after eating certain foods. OAS is caused by cross-reactivity among a class of proteins ubiquitous in plants called pathogenesis related class 10 (PR-10) proteins. The best characterized PR-10 protein is Bet v 1 from birch pollen and its putative function is binding hydrophobic ligands. We cloned a subset of seven recombinant PR-10 proteins from pollens, peanuts, and hazelnuts and developed a standard purification method for them. Immunoglobulin E (IgE) binding of purified PR-10 proteins was analyzed by ImmunoCAP ISAC microarray and enzyme-linked immunosorbent assays (ELISAs) with sera from allergic patients. We investigated the binding activities of PR10s by testing 16 different ligands with each protein and compared their secondary structures using circular dichroism (CD). The PR-10s in this study had very similar CD spectra, but bound IgE with very different affinities. All seven proteins showed a similar pattern of binding to the polyphenol ligands (resveratrol, flavonoids, and isoflavones) and variable binding to other potential ligands (fatty acids, sterols, and plant hormones). We suggest our protocol has the potential to be a near-universal method for PR-10 purification that will facilitate further research into this important class of panallergens.

Cross-reactivity between raw mushroom and molds in a patient with oral allergy syndrome

2002 ◽  
Vol 89 (3) ◽  
pp. 319-321 ◽  
Author(s):  
Pierre-Alain L. Dauby ◽  
Bonnie A. Whisman ◽  
Larry Hagan
Keyword(s):  
Cross Reactivity ◽  
Oral Allergy Syndrome

scholarly journals Alergeny ziół kulinarnych i warzyw ważne dla pielęgniarki lub dietetyczki

2020 ◽  
Vol 5 (3) ◽  
pp. 117-136
Author(s):  
Krzysztof Buczyłko ◽  
Keyword(s):  
At Risk ◽  
Allergic Diseases ◽  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Molecular Allergology ◽  
Culinary Herbs

Introduction. New allergenic sources causing the oral allergy syndrome and other allergic diseases have been reported. Overview. The spices, vegetables and some culinary herbs allergenic mole-cules have been identified and presented with their cross-reactivity possibili-ties. Some of the molecules generally considered not to be at risk for severe reactions have been demonstrated to pose a threat for inducing generalized reactions. Conclusions. Molecular allergology basic rules are useful for nurses and dieti-tians as well.

Sign in / Sign up

Export Citation Format

Share Document