Cardiorespiratory and all-cause mortality after restrictions on sulphur content of fuel in Hong Kong: an intervention study

The Lancet ◽  
2002 ◽  
Vol 360 (9346) ◽  
pp. 1646-1652 ◽  
Author(s):  
Anthony Johnson Hedley ◽  
Chit-Ming Wong ◽  
Thuan Quoc Thach ◽  
Stefan Ma ◽  
Tai-Hing Lam ◽  
...  
2019 ◽  
Vol 31 (4) ◽  
pp. 561-581
Author(s):  
Carrie Lau ◽  
Ying Wang ◽  
Stephanie W Y Chan ◽  
Eva E Chen ◽  
Catherine McBride ◽  
...  

2017 ◽  
Vol 37 (5) ◽  
pp. 556-561 ◽  
Author(s):  
Ching-Shan Yeung ◽  
Chi-Yuen Cheung ◽  
Yiu-Han Chan ◽  
Wai-Leung Chak

BackgroundVancomycin-resistant Enterococcus (VRE) colonization is common among patients with chronic kidney disease. However, data concerning VRE colonization among patients receiving peritoneal dialysis (PD) is lacking. The aim of this study is to evaluate the risk factors and various clinical outcomes for VRE colonization among PD patients.MethodsThis is a retrospective cohort study of 166 PD patients who were hospitalized between 1 August 2013 and 31 July 2014. They were screened for VRE colonization status during a major VRE outbreak in Hong Kong in 2013 and were then categorized into 2 groups: VRE-positive and VRE-negative. The primary outcome was all-cause mortality while the secondary outcomes included VRE infection, PD-related peritonitis, and length of hospitalization.ResultsTwenty-eight patients (16.9%) belonged to the VRE-positive group. Multivariate analysis showed that previous contact with VRE-positive patients (odds ratio [OR]: 417.86; 95% confidence interval [CI]: 17.21 – 10,147.26, p < 0.01), vancomycin use in previous 3 months (OR: 130.32; 95% CI: 5.35 – 3,176.30, p < 0.01), and old age (OR: 1.13; 95% CI: 1.02 – 1.24, p = 0.02) were the independent risk factors for VRE colonization. Patients in the VRE-positive group had significantly longer length of hospitalization, but there was no significant difference in all-cause mortality and peritonitis-free survival.ConclusionVancomycin-resistant Enterococcus colonization is important among hospitalized PD patients. Cautious use of antibiotics and infection control measures are necessary to prevent VRE spreading, especially in high-risk patients.


2008 ◽  
Vol 24 (3) ◽  
pp. 238-246 ◽  
Author(s):  
Wing Yee So ◽  
Xilin Yang ◽  
Ronald C. W. Ma ◽  
Alice P. S. Kong ◽  
Christopher W. K. Lam ◽  
...  

2021 ◽  
Author(s):  
Ishan Lakhani ◽  
Jiandong Zhou ◽  
Sharen Lee ◽  
Ka Hou Christien Lee ◽  
Keith Sai Kit Leung ◽  
...  

Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a hereditary disease characterized by fibrofatty infiltration of the right ventricular myocardium that predisposes affected patients to malignant ventricular arrhythmias, dual-chamber cardiac failure and sudden cardiac death (SCD). The present study aims to investigate the risk of detrimental cardiovascular events in an Asian population of ARVC/D patients, including the incidence of malignant ventricular arrhythmias, new-onset heart failure with reduced ejection fraction (HFrEF), as well as long-term mortality. Methods and Results: This was a territory-wide retrospective cohort study of patients diagnosed with ARVC/D between 1997 and 2019 in Hong Kong. This study consisted of 109 ARVC/D patients (median age: 61 [46-71] years; 58% male). Of these, 51 and 24 patients developed incident VT/VF and new-onset HFrEF, respectively. Five patients underwent cardiac transplantation, and 14 died during follow-up. Multivariate Cox regression identified prolonged QRS duration as a predictor of VT/VF (p < 0.05). Female gender, prolonged QTc duration, the presence of epsilon waves and T-wave inversion (TWI) in any lead except aVR/V1 predicted new-onset HFrEF (P < 0.05. The presence of epsilon waves, in addition to the parameters of prolonged QRS duration and worsening ejection fraction predicted all-cause mortality (p<0.05). Clinical scores were developed to predict incident VT/VF, new-onset HFrEF and all-cause mortality, and all were significantly improved by machine learning techniques. Conclusion: Clinical and electrocardiographic parameters are important for assessing prognosis in ARVC/D patients and should in turn be used in tandem to aid risk stratification in the hospital setting.


2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 977-977
Author(s):  
D Jiang ◽  
L Warner ◽  
A Chong ◽  
T Li ◽  
J Wolff ◽  
...  

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