EARLY ONSET OF SKIN AND ORAL CAVITY NEOPLASMS IN XERODERMA PIGMENTOSUM

ABSTRACT The xeroderma pigmentosum group G (XP-G) gene (XPG) encodes a structure-specific DNA endonuclease that functions in nucleotide excision repair (NER). XP-G patients show various symptoms, ranging from mild cutaneous abnormalities to severe dermatological impairments. In some cases, patients exhibit growth failure and life-shortening and neurological dysfunctions, which are characteristics of Cockayne syndrome (CS). The known XPG protein function as the 3′ nuclease in NER, however, cannot explain the development of CS in certain XP-G patients. To gain an insight into the functions of the XPG protein, we have generated and examined mice lacking xpg (the mouse counterpart of the humanXPG gene) alleles. The xpg-deficient mice exhibited postnatal growth failure and underwent premature death. SinceXPA-deficient mice, which are totally defective in NER, do not show such symptoms, our data indicate that XPG performs an additional function(s) besides its role in NER. Our in vitro studies showed that primary embryonic fibroblasts isolated from thexpg-deficient mice underwent premature senescence and exhibited the early onset of immortalization and accumulation of p53.

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Real-size CT Slices to Optimize Brachytherapy in the Plastic Tube Technique for Oral Cavity Neoplasms

Medical Dosimetry ◽

10.1016/s0958-3947(98)00007-7 ◽

1998 ◽

Vol 23 (2) ◽

pp. 109-111

Author(s):

A Rovirosa

Keyword(s):

Oral Cavity ◽

Plastic Tube ◽

Real Size ◽

Ct Slices ◽

Oral Cavity Neoplasms

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Periodontal disease in dogs and cats referred to the Veterinary Hospital of UFMT, Campus Sinop, MT

Scientific Electronic Archives ◽

10.36560/832015188 ◽

2015 ◽

Vol 8 (3) ◽

pp. 16-24

Author(s):

A. Camargo ◽

A. A. Novais ◽

D. Faria Júnior

Keyword(s):

Oral Health ◽

Oral Cavity ◽

Periodontal Disease ◽

Dental Care ◽

Early Onset ◽

Small Animal ◽

Predisposing Factor ◽

Animal Surgery ◽

Veterinary Hospital ◽

Interest And Knowledge

Canine and feline oral cavity was examined, referred to the small animal surgery and obstetric classes of the school veterinary hospital, between 2013, August and December. The study was conducted using a dental chart developed to enable proper oral assessment. The data were compared to the information relayed by the owners, mostly based on the type of food that was given to their pets and used dental care to keep the oral health of their animals. The results showed a lack of owners interest and knowledge about their pets dental care and, additionally, that most animals was not receiving adequate pet meal, what caused accumulation of food between the teeth and the early onset of periodontal disease. Finally, it was concluded that age is an important predisposing factor for the disease.

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“A HISTOPATHOLOGICAL STUDY OF TUMORS OF ORAL CAVITY”

10.36106/gjra/7400150 ◽

2021 ◽

pp. 1-5

Author(s):

P.V. Kala Chandra Sekhar ◽

B. victor Paul

Keyword(s):

Oral Cancer ◽

Oral Cavity ◽

Squamous Cell ◽

Tobacco Consumption ◽

Histopathological Study ◽

Invasive Squamous Cell Carcinoma ◽

College Hospital ◽

Oral Cancers ◽

Associated Risk Factors ◽

Oral Cavity Neoplasms

Background: The incidence of oral cavity neoplasms in the population has increased manifold over the years. Oral cancer is one of the common cancers in the world, common in India, and also in Bangladesh, Srilanka and Pakistan. Oral cancer is one of the few cancers, whose cause were known and hence it is possible to prevent. The real challenge in oral cancer lies in its prevention and early diagnosis. Objectives: 1.To study the morphological spectrum of neoplasms in oral cavity. 2.To study the age and gender incidence of various neoplasms. 3.To study the commonest sites of various neoplasms. 4.To evaluate or analyse the associated risk factors. Materials and methods: This is a prospective study of the cases attended to Government General Hospital, Vijayawada or Government Dental College Hospital Vijayawada, of oral cavity neoplasms. The biopsy of the tissues was carried out at the Department of Pathology, Siddhartha Medical College, Vijayawada. The study period was from June 2011 to August 2013 over a period of two years and three months. Results: The Study comprises a total of 74 surgical biopsies from oral cavity neoplasms received in the Department of Pathology, 52 of these were malignant lesions and 20 were benign tumour and 2 were premalignant conditions. The invasive squamous cell carcinoma was the most frequent histological type of oral cavity neoplasms. Among the oral cancers, peak age th th incidence was the 5 and 6 decade of life. There was signicant male preponderance. Tongue was the most common site involved. Smokeless tobacco consumption was the commonest associated habit which leads to malignancy. Conclusion:In thisa study we observed that among the oral cavity neoplasms, high incidence of carcinomas are seen, among these squamous cell carcinomas are predominant.

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Retrospective Study of Feline Oral Cavity Neoplasms and Non-neoplastic Lesions, Between 2010 and 2020

10.5152/actavet.2021.21018 ◽

2021 ◽

Author(s):

Hazal OZTURK GURGEN ◽

◽

Pembe Dilara KECICI ◽

Gulay YUZBASIOGLU ◽

Aydin GUREL ◽

...

Keyword(s):

Retrospective Study ◽

Oral Cavity ◽

Neoplastic Lesions ◽

Oral Cavity Neoplasms

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Novel variants in POLH and TREM2 genes associated with a complex phenotype of xeroderma pigmentosum variant type and early‐onset dementia

Molecular Genetics & Genomic Medicine ◽

10.1002/mgg3.1491 ◽

2020 ◽

Vol 8 (11) ◽

Author(s):

Izadora Fonseca Zaiden Soares ◽

Denise Maria Christofolini ◽

Lis Gomes Silva ◽

David Feder ◽

Alzira Alves Siqueira Carvalho

Keyword(s):

Early Onset ◽

Xeroderma Pigmentosum ◽

Complex Phenotype ◽

Early Onset Dementia ◽

Variant Type ◽

Novel Variants

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Study of Oral Cavity Neoplasms

International Journal of Science and Research (IJSR) ◽

10.21275/v5i7.art2016286 ◽

2016 ◽

Vol 5 (7) ◽

pp. 623-625

Keyword(s):

Oral Cavity ◽

Oral Cavity Neoplasms

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Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

American Journal of Speech-Language Pathology ◽

10.1044/2019_ajslp-19-00095 ◽

2020 ◽

Vol 29 (2) ◽

pp. 864-872

Author(s):

Fernanda Borowsky da Rosa ◽

Adriane Schmidt Pasqualoto ◽

Catriona M. Steele ◽

Renata Mancopes

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Oral Cavity ◽

Pulmonary Disease ◽

Thermal Sensation ◽

Sensory Function ◽

Control Group ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Age Related ◽

Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

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