scholarly journals EP-1258: Concurrent high-dose (60-70 Gy) radiation and chemotherapy for esophageal cancer: long-term results

2016 ◽  
Vol 119 ◽  
pp. S594
Author(s):  
T. Kondo ◽  
Y. Shibamoto ◽  
A. Hayashi ◽  
A. Miyakawa ◽  
T. Murai ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Long Term Results ◽  
High Dose

Short- and long-term outcomes in patients operated with total minimally invasive esophagectomy for esophageal cancer

2021 ◽  
Author(s):  
Tobias Hauge ◽  
Dag T Førland ◽  
Hans-Olaf Johannessen ◽  
Egil Johnson
Keyword(s):  
Overall Survival ◽  
Esophageal Cancer ◽  
Minimally Invasive ◽  
Minimally Invasive Esophagectomy ◽  
University Hospital ◽  
Long Term Results ◽  
Resection Margins ◽  
Invasive Esophagectomy ◽  
Short And Long Term

Summary At our hospital, the main treatment for resectable esophageal cancer (EC) has since 2013 been total minimally invasive esophagectomy (TMIE). The aim of this study was to present the short- and long-term results in patients operated with TMIE. This cross-sectional study includes all patients scheduled for TMIE from June 2013 to January 2016 at Oslo University Hospital. Data on morbidity, mortality, and survival were retrospectively collected from the patient administration system and the Norwegian Cause of Death Registry. Long-term postoperative health-related quality of life (HRQL) and level of dysphagia were assessed by patients completing the following questionaries: EORTC QLQ-OG25, QLQ-C30, and the Ogilvie grading scale. A total of 123 patients were included in this study with a median follow-up time of 58 months (1–88 months). 85% had adenocarcinoma, 15% squamous cell carcinoma. Seventeen patients (14%) had T1N0M0, 68 (55%) T2-T3N0M0, or T1-T2N1M0 and 38 (31%) had either T3N1M0 or T4anyNM0. Ninety-eight patients (80%) received neoadjuvant (radio)chemotherapy and 104 (85%) had R0 resection. Anastomotic leak rate and 90-days mortality were 14% and 2%, respectively. The 5-year overall survival was 53%. Patients with tumor free resection margins of >1 mm (R0) had a 5-year survival of 57%. Median 60 months (range 49–80) postoperatively the main symptoms reducing HRQL were anxiety, chough, insomnia, and reflux. Median Ogilvie score was 0 (0–1). In this study, we report relatively low mortality and good overall survival after TMIE for EC. Moreover, key symptoms reducing long-term HRQL were identified.

High dose rate brachytherapy and external beam: long-term results in cancer of the prostate

2003 ◽  
Vol 57 (2) ◽  
pp. S395-S396
Author(s):  
D.J Demanes ◽  
R.R Rodriguez ◽  
L Schour ◽  
D Brandt ◽  
J Quackenbush ◽  
...  
Keyword(s):  
Dose Rate ◽  
High Dose Rate ◽  
Long Term Results ◽  
High Dose ◽  
External Beam ◽  
High Dose Rate Brachytherapy ◽  
Cancer Of The Prostate

M1974 Clinicopathological Characteristics of Barrett's Esophageal Cancer in Japanese Patients and Long-Term Results of Therapy

2009 ◽  
Vol 136 (5) ◽  
pp. A-459
Author(s):  
Tomoyuki Koike ◽  
Toru Horii ◽  
Shuichi Ohara ◽  
Yasuhiko Abe ◽  
Katsunori Iijima ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Japanese Patients ◽  
Clinicopathological Characteristics ◽  
Long Term Results

Long-Term Results After High-Dose Radiotherapy and Adjuvant Hormones in Prostate Cancer: How Curable Is High-Risk Disease?

2011 ◽  
Vol 81 (5) ◽  
pp. 1279-1285 ◽  
Author(s):  
Almudena Zapatero ◽  
Feliciano García-Vicente ◽  
Carmen Martín de Vidales ◽  
Alfonso Cruz Conde ◽  
Yamile Ibáñez ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Long Term Results ◽  
High Dose ◽  
High Risk Disease

Outcome of patients with Hodgkin's disease failing after primary MOPP-ABVD.

1997 ◽  
Vol 15 (2) ◽  
pp. 528-534 ◽  
Author(s):  
V Bonfante ◽  
A Santoro ◽  
S Viviani ◽  
L Devizzi ◽  
M Balzarotti ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Complete Remission ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Response Duration ◽  
Long Term Results ◽  
High Dose ◽  
First Line ◽  
Disease Extent

PURPOSE This study analyzed long-term results in patients with Hodgkin's disease who were resistant to or relapsed after first-line treatment with MOPP and ABVD. Response to salvage treatments and prognostic factors were also evaluated. PATIENTS AND METHODS The study population included 115 refractory or relapsed patients among a total of 415 patients treated with alternating or hybrid MOPP-ABVD followed by radiotherapy (25 to 30 Gy) to initial bulky sites. The median follow-up duration of the present series was 91 months. Thirty-nine of 115 patients (34%) showed disease progression while on primary treatment (induction failures); 48 relapsed after complete remissions that lasted < or = 12 months and 28 after complete remission that lasted more than 12 months from the end of all treatments. RESULTS At 8 years, the overall survival rate was 27%, being 54% and 28% in patients whose initial complete remission was longer or shorter than 12 months, respectively, and 8% in induction failures (P < .001). Response to first-line chemotherapy and disease extent at first progression significantly influenced long-term results, as well as the incidence and duration of complete remission. CONCLUSION The present data confirm previous observations that showed the main prognostic factors to influence outcome after salvage treatment are response duration to first-line therapy and disease extent at relapse. The results indicate that patients who relapse after the alternating MOPP/ABVD regimen have a prognosis similar to that of patients who relapse after a four-drug regimen (MOPP or ABVD alone). Re-treatment with initial chemotherapy seems the treatment of choice for patients who relapse after an initial complete remission that lasts greater than 12 months, while the real impact of high-dose chemotherapy or new regimens should be assessed in resistant patients.

Leiomyoma of the Esophagus

1986 ◽  
Vol 72 (5) ◽  
pp. 503-506 ◽  
Author(s):  
Ferdinando Preda ◽  
Marco Alloisio ◽  
Cosimo Lequaglie ◽  
Mauro Ongari ◽  
Gianluigi Ravasi
Keyword(s):  
Esophageal Cancer ◽  
Differential Diagnosis ◽  
Preoperative Diagnosis ◽  
Long Term Results ◽  
Barium Swallow ◽  
Thoracic Esophagus ◽  
Esophageal Leiomyoma ◽  
Correct Preoperative Diagnosis ◽  
Clinical Records

A review of the clinical records from 1947 to 1984 of the Istituto Nazionale Tumori of Milan provided 20 cases (14 males and 6 females) of esophageal leiomyoma. Eighteen of the tumors were in the thoracic esophagus and 2 were at the cardiac level. The most frequent symptoms were dysphagia, slight epigastralgia and odynophagia. Differential diagnosis should be made with mediastinic neoplasms and esophageal cancer. Barium swallow and esophagoscopy are the most sensitive procedures for a correct preoperative diagnosis. Surgery is mandatory because of the tendency to a continuous endoluminal growth (in 97% of the cases) and a possible malignant transformation. However, surgery is conservative: extramucosal enucleation of the leiomyoma is the procedure of choice. The long-term results are excellent, and morbidity is acceptable.

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