Biodegradable polyanhydride devices of cefazolin sodium, bupivacaine, and taxol for local drug delivery: preparation, and kinetics and mechanism of in vitro release

ABSTRACTObjective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,32 mg and 48 mg) respectively beside to the combination effect of polymers on the release of the drug from the tablet.Results: In vitro release showed that formula 13 had the faster release (100% after 4 h) which contained acacia (1:1) and the lowest sustain releasewas showed for F7 (73% after 8 h) which contained HPMC K100M (1:1). Formula 1 was an 89 % release after 8 h which contain eudragit RS100; F4was a 100 % release after 5 h which contain Na CMC, F10 was a 100% after 8 h which contain xanthan gum and F16 was a 100 % release after 5 hwhich contain tragacanth polymer. Formula 9 had a lower release than F7 and F8 respectively. Formula 7 can be used for sustain oral drug delivery ofcandesartan cilexetil while Formula 13 can be used in contrary as fast release tablets for faster response.Conclusion: Controlled drug delivery system is promising for less dosing and higher patient compliance.Keywords: Angiotensin II receptor antagonist, Hypertension, Matrix system, Control release.

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Photo-Switchable Nanomechanical Systems Comprising a Nanocontainer (Montmorillonite) and Light-Driven Molecular Jack (Azobenzene-Imidazolium Ionic Liquids) as Drug Delivery Systems; Synthesis, Characterization, and in Vitro Release Studies

ACS Biomaterials Science & Engineering ◽

10.1021/acsbiomaterials.7b00621 ◽

2017 ◽

Vol 4 (1) ◽

pp. 184-192 ◽

Cited By ~ 8

Author(s):

Abdolrahim Abbaszad Rafi ◽

Nazila Hamidi ◽

Abdollah Bashir-Hashemi ◽

Mehrdad Mahkam

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Drug Delivery Systems ◽

In Vitro Release ◽

Delivery Systems ◽

Imidazolium Ionic Liquids ◽

Release Studies ◽

Nanomechanical Systems ◽

Vitro Release

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Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release

Journal of the European Ceramic Society ◽

10.1016/j.jeurceramsoc.2012.01.018 ◽

2012 ◽

Vol 32 (11) ◽

pp. 2679-2690 ◽

Cited By ~ 27

Author(s):

Hiva Baradari ◽

Chantal Damia ◽

Maggy Dutreih-Colas ◽

Etienne Laborde ◽

Nathalie Pécout ◽

...

Keyword(s):

Drug Delivery ◽

Calcium Phosphate ◽

Drug Delivery Systems ◽

Drug Carrier ◽

Drug Loading ◽

In Vitro Release ◽

Delivery Systems ◽

Vitro Release

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Nanostructured Lipid Carriers for Intranasal Administration of Olanzapine in the management of Schizophrenia

Current Molecular Pharmacology ◽

10.2174/1874467214666210120160016 ◽

2021 ◽

Vol 14 ◽

Author(s):

Sarbjot Kaur ◽

Ujjwal Nautiyal ◽

Pooja A. Chawla ◽

Viney Chawla

Keyword(s):

Drug Delivery ◽

Ex Vivo ◽

In Vitro Release ◽

Nanostructured Lipid Carriers ◽

Polydispersity Index ◽

Poloxamer 407 ◽

Ex Vivo Permeation ◽

Permeation Studies ◽

Vitro Release

Background: Background: Olanzapine belongs to a new class of dual spectrum antipsychotic agents. It is known to show promise in managing both the positive and negative symptoms of schizophrenia. Drug delivery systems based on nanostructured lipid carriers (NLC) are expected to provide rapid nose-to-brain transport of this drug and improved distribution into and within the brain. Objective: The present study deals with the preparation and evaluation of olanzapine loaded NLC via the intranasal route for schizophrenia. Methods: Olanzapine-NLC were formulated through the solvent injection method using isopropyl alcohol as the solvent, stearic acid as solid lipid, and oleic acid as liquid lipid, chitosan as a coating agent, and Poloxamer 407 as a surfactant. NLC were characterized for particle size, polydispersity index, entrapment efficiency, pH, viscosity, X-ray diffraction studies, in-vitro mucoadhesion study, in- vitro release and ex-vivo permeation studies. The shape and surface morphology of the prepared NLC was determined through transmission electron microscopy. To detect the interaction of the drug with carriers, compatibility studies were also carried out. Results: Average size and polydispersity index of developed formulation S6 was 227.0±6.3 nm and 0.460 respectively. The encapsulation efficiency of formulation S6 was found to be 87.25 %. The pH, viscosity, in-vitro mucoadhesion study, and in- vitro release of optimized olanzapine loaded NLC were recorded as 5.7 ± 0.05, 78 centipoise, 15±2 min, and 91.96 % respectively. In ex-vivo permeation studies, the percent drug permeated after 210 min was found to be 84.03%. Conclusion: These results reveal potential application of novel olanzapine-NLC in intranasal drug delivery system for treatment of schizophrenia.

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Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

Polymers ◽

10.3390/polym12071473 ◽

2020 ◽

Vol 12 (7) ◽

pp. 1473 ◽

Cited By ~ 1

Author(s):

Ioana A. Duceac ◽

Liliana Verestiuc ◽

Cristina D. Dimitriu ◽

Vasilica Maier ◽

Sergiu Coseri

Keyword(s):

Drug Delivery ◽

Wound Dressing ◽

In Vitro Release ◽

Local Drug Delivery ◽

Acrylic Polymers ◽

Modified Chitosan ◽

Porous Networks ◽

Preparation Conditions ◽

Swelling Mechanism

The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.

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Effect of Surfactants on Characteristic and In Vitro Release of Meloxicam Loaded in Deformable Liposomes

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.506.457 ◽

2012 ◽

Vol 506 ◽

pp. 457-460

Author(s):

Sureewan Duangjit ◽

Praneet Opanasopit ◽

Theerasak Rojanarata ◽

Tanasait Ngawhirunpat

Keyword(s):

Drug Delivery ◽

In Vitro Release ◽

Entrapment Efficiency ◽

Sodium Cholate ◽

Drug Delivery Carrier ◽

Release Study ◽

Water Insoluble Drug ◽

Vitro Release ◽

Potential Use

The aim of this study was to investigate the effect of surfactants on characteristic and in vitro release of liposomes containing meloxicam (MX), model of water insoluble drug. The potential use of deformable liposomes for drug delivery system was developed and investigated. The formulation composed of constant amount of phosphatidylcholine (PC) and MX and various amounts of cholesterol (Chol), sodium cholate (NaChol), sodium oleate (NaO) and stearylamine (SA) was formulated by reverse phase evaporation method. The vesicle size, zeta potential, morphology, entrapment efficiency, loading efficiency, stability andin vitrorelease study were evaluated. The result indicated that the entrapment efficiency andin vitrorelease study of vesicle formulations containing surfactants were significantly higher than the conventional liposome and MX suspension. The formulation of 10:2:2:5 PC/MX/Chol/NaO provided the maximum entrapment efficiency and drug release. Our research suggested that MX loaded in deformable liposomes containing surfactants can be potentially used as a drug delivery carrier for water insoluble drug.

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