QTc prolongation in type II diabetic patients with hypertension and ischemic heart disease

2000 ◽  
Vol 50 ◽  
pp. 287
Author(s):  
M Khelashvili ◽  
R Kurashvili ◽  
T Akhobadze ◽  
M Dundua ◽  
E Shelestova
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Diabetic Patients ◽  
Type Ii ◽  
Qtc Prolongation

scholarly journals COMPARATIVE STUDY OF LEVELS OF SELECTIVE OXIDATIVE STRESS MARKERS (MALONDIALDEHYDE, ZINC, AND ANTIOXIDANT VITAMINS A, E, AND C) IN ISCHEMIC AND NON-ISCHEMIC HEART DISEASE PATIENTS SUFFERING FROM TYPE- 2 DIABETES

2018 ◽  
Vol 11 (8) ◽  
pp. 508
Author(s):  
Abd Elgadir A Altoum ◽  
Ahmed L Osman ◽  
Asaad Ma Babker
Keyword(s):  
Oxidative Stress ◽  
Heart Disease ◽  
Vitamin A ◽  
Ischemic Heart Disease ◽  
Serum Vitamin ◽  
Antioxidant Vitamins ◽  
Ischemic Heart ◽  
Diabetic Patients ◽  
Oxidative Stress Markers ◽  
Stress Markers

Objective: The objective of the current study is to compare the levels of oxidative stress markers malondialdehyde (MDA), zinc, and antioxidant Vitamins (A, E, and C) in ischemic heart disease (IHD) and non-IHD patients with diabetes mellitus.Method: This is cross-sectional study group, conducted in the advanced diagnostic center (Khartoum- Sudan) from the period May 2013 to August 2015. Comprised 100 healthy subjects were, control group with mean (fasting blood sugar) 5.61=m mol/L, the age ranged from 22 to 78 years old, the average of the age was 50.1 years. 300 patients (78 IHD and 222 without) as cases groups, the ages ranged from 30 to 80 years. The age average was 51.2 years, all samples were in a state of fasting for 12 h, and the data were collected using a structured questionnaire and direct interview to collect information. Blood specimens were collected from both groups, and plasma levels of MDA, zinc, and antioxidant Vitamins (A, E, and C) were determined.Results: There was a significant difference between the level of serum Vitamin A, E, and MDA in diabetic patients with IHD and those diabetic without IHD (p<0.05). No significant differences in serum Vitamin C level between both groups (p>0.05).Conclusion: Due to the significant differences in serum Vitamin A, E, Zinc, and MDA between diabetics with IHD and diabetics without IHD, these parameters can be used as prognostic markers for prediction of oxidative stress and antioxidant stress of diabetic patients with IHD complications.

Plasma C3d Levels and Ischemic Heart Disease in Type II Diabetes

Diabetes Care ◽  
1993 ◽  
Vol 16 (2) ◽  
pp. 445-449 ◽  
Author(s):  
A. Figueredo ◽  
J. L. Ibarra ◽  
J. Bagazgoitia ◽  
A. Rodriguez ◽  
A. M. Molino ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Type Ii Diabetes ◽  
Ischemic Heart ◽  
Type Ii

scholarly journals Comparative Study of Triglyceride Level in Ischemic Heart Disease Patients in different age groups of Patients in south east Rajasthan

2018 ◽  
Vol 6 (2) ◽  
pp. 92-99
Author(s):  
Darab Singh Underwal ◽  
Sushma Pandey ◽  
Deepak Gupta
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Triglyceride Level ◽  
Colorimetric Method ◽  
Serum Triglyceride ◽  
Ischemic Heart ◽  
Diabetic Patients ◽  
Serum Triglyceride Level ◽  
Elderly Male ◽  
Male Patients

Backgrounds: Elevated body triglycerides have been implicated as a risk factor of ischemic heart disease (IHD).Objectives: To study the association of serum triglyceride with ischemic heart disease and to assess the relationship of serum triglyceride with other established conventional risk factors.Methods: A cross sectional case-control study of 75 cases of IHD and 75 controls without having any evidence of IHD/CHD between age group 30-70 years. Serum triglyceride levels were estimated by using Colorimetric Method and other risk factors by enzymatic methods.Results: Mean serum triglyceride (263.674 ± 89.029mg/dl) was significantly higher in cases than controls (98.833 ± 62.682mg/dl). Amongst the patients of IHD, significantly higher level of Serum triglyceride was found in diabetics (340.63±90.78mg/dl) than non-diabetics (225.19±58.30mg/dl), male elderly (>60years of age) smokers (304.20±88.60mg/dl) compared to non smoker (206.37±48.88mg/dl), elderly male with high (>150mg/dl) LDL (323.48±86.73mg/dl) compared to patients with normal (<150mg/dl) LDL (249.33±66.12 mg/dl). Similarly male patients of IHD with high (>40mg/dl) VLDL had significantly higher serum triglyceride (326.49±77.95mg/dl) compared to male patients with normal (<40mg/dl) VLDL (257.18±85.46mg/dl).Conclusion: High serum triglyceride level (>200mg/dl) may provide a cost effective tool for predicting an impending ischemic heart disease especially in diabetic patients, male elderly smokers, elderly males with high LDL, male patients of ischemic heart disease with high VLDL level.

scholarly journals Incidence of Heart Failure among Diabetic Patients with Ischemic Heart Disease: A Cohort Study

2020 ◽  
Author(s):  
Senbeta Guteta Abdissa ◽  
Wakgari Deressa ◽  
Amit J Shah
Keyword(s):  
Heart Failure ◽  
Risk Factor ◽  
Cohort Study ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Independent Risk Factor ◽  
Cox Regression ◽  
Addis Ababa ◽  
Ischemic Heart ◽  
Diabetic Patients

Abstract Background: In population studies of heart failure (HF), diabetes has been shown to be an independent risk factor. However, the evidence evaluating diabetes mellitus (DM) as an independent risk factor in incident HF in patients with ischemic heart disease (IHD) is scarce. Our study aimed to assess the incidence of HF in diabetic IHD patients compared to non-diabetic IHD patients in Ethiopia.Methods: A retrospective cohort study was conducted among 306 patients with IHD followed-up at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia. The IHD patients who did not have HF at baseline were followed for 24 months beginning from November 30, 2015. We assessed the incidence of HF in patients with diabetic IHD versus the non-diabetic IHD. Cox proportional hazards models were used to assess the association between diabetic IHD and HF after controlling for important covariates. Hypertension was examined as a possible effect modifier as well.Results: The mean age was 56.8 years, 69% were male, and 31% were diabetic. During the 24 months follow-up period, 196 (64.1%) had incident HF. On multivariate Cox regression, DM was significantly associated with incident HF [Hazard Ratio = 2.04, 95% confidence interval (CI): 1.32-3.14, p = 0.001]. Furthermore, when the patients were stratified by hypertension (HTN), DM was associated with worse prognosis, the strongest association being in those with co-existing DM and HTN [HR = 2.57,95% CI =1.66-3.98, p<0.0001] followed by the presence of DM without HTN [HR 2.27, 95% CI = 1.38-3.71, p=0.001] (compared to those with neither). Conclusion: DM is the strongest predictor of incident HF, compared to other traditional risk factors, in Ethiopian patients with IHD. Those with both DM and HTN are at the highest risk.

scholarly journals Plasma levels of pentosidine in diabetic patients: an advanced glycation end product.

1998 ◽  
Vol 9 (9) ◽  
pp. 1681-1688
Author(s):  
S Sugiyama ◽  
T Miyata ◽  
Y Ueda ◽  
H Tanaka ◽  
K Maeda ◽  
...  
Keyword(s):  
Renal Function ◽  
Regression Analysis ◽  
Heart Disease ◽  
Serum Creatinine ◽  
Ischemic Heart Disease ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Ischemic Heart ◽  
Diabetic Patients ◽  
Advanced Glycation

Nonenzymatic reactions between glucose and proteins yield advanced glycation end products (AGE) such as pentosidine. AGE accumulate in diabetic patients, alter the structure and function of tissue proteins, stimulate cellular response, and have thus been implicated in diabetic tissue damage. The present study was undertaken to assess the factors determining plasma total pentosidine level in diabetic patients and the possible relation between plasma pentosidine level and diabetic complications. In diabetic patients, including patients with renal failure, plasma pentosidine levels, assessed by HPLC assay, were correlated with serum creatinine (P < 0.0001). In patients with normal renal function, pentosidine levels were correlated with blood glucose control (hemoglobin Alc: P = 0.0028; fructoselysine: P = 0.0133), serum creatinine (P = 0.029), patient age (P = 0.0416), duration of diabetes (P = 0.0431), and total cholesterol (P = 0.0056) and LDL-cholesterol (P = 0.0208). Multiple regression analysis revealed an independent influence of hemoglobin Alc and serum creatinine on pentosidine levels (r2 = 0.216, P = 0.0026). Pentosidine levels were higher in patients with than in those without hypertension (P = 0.043) or ischemic heart diseases (P = 0.0061). No such differences were observed between patients with and without albuminuria or retinopathy. Multiple regression analysis revealed an independent influence of plasma pentosidine on the presence of hypertension (r2 = 0.129, P = 0.0382) and of plasma pentosidine and HDL-cholesterol on the presence of ischemic heart disease (r2 = 0.326, P = 0.0012). The present study demonstrated that plasma pentosidine level was significantly influenced by the quality of glycemic control and renal function. Pentosidine level was also correlated with hypertension and ischemic heart disease, and might be taken as a biomarker of diabetic cardiovascular risk.

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