IL-7 Induced Traf1 Up-Regulation Restores HCV-Specific CD8 T Cell Reactivity in Mid-Lasting HCV Infection Featured by Presence of Directly Ex-Vivo Detectable Pentamer Binding Cells

The emergence of SARS-CoV-2 variants highlighted the need to better understand adaptive immune responses to this virus. It is important to address whether also CD4+ and CD8+ T cell responses are affected, because of the role they play in disease resolution and modulation of COVID-19 disease severity. Here we performed a comprehensive analysis of SARS-CoV-2-specific CD4+ and CD8+ T cell responses from COVID-19 convalescent subjects recognizing the ancestral strain, compared to variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C as well as recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines. Similarly, we demonstrate that the sequences of the vast majority of SARS-CoV-2 T cell epitopes are not affected by the mutations found in the variants analyzed. Overall, the results demonstrate that CD4+ and CD8+ T cell responses in convalescent COVID-19 subjects or COVID-19 mRNA vaccinees are not substantially affected by mutations found in the SARS-CoV-2 variants.

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Local CD4 and CD8 T-Cell Reactivity to HSV-1 Antigens Documents Broad Viral Protein Expression and Immune Competence in Latently Infected Human Trigeminal Ganglia

PLoS Pathogens ◽

10.1371/journal.ppat.1003547 ◽

2013 ◽

Vol 9 (8) ◽

pp. e1003547 ◽

Cited By ~ 59

Author(s):

Monique van Velzen ◽

Lichen Jing ◽

Albert D. M. E. Osterhaus ◽

Alessandro Sette ◽

David M. Koelle ◽

...

Keyword(s):

T Cell ◽

Protein Expression ◽

Viral Protein ◽

Cd8 T Cell ◽

Trigeminal Ganglia ◽

Immune Competence ◽

Cell Reactivity ◽

Viral Protein Expression ◽

Latently Infected ◽

T Cell Reactivity

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Rescue of memory CD8+ T cell reactivity in peptide/TLR9 ligand immunization by codelivery of cytokines or CD40 ligation

Virology ◽

10.1016/j.virol.2004.10.022 ◽

2005 ◽

Vol 331 (1) ◽

pp. 151-158 ◽

Cited By ~ 18

Author(s):

Felix N. Toka ◽

Małgorzata Gieryńska ◽

Susmit Suvas ◽

Stephen P. Schoenberger ◽

Barry T. Rouse

Keyword(s):

T Cell ◽

Cd8 T Cell ◽

Cd40 Ligation ◽

Cell Reactivity ◽

Tlr9 Ligand ◽

Memory Cd8 T Cell ◽

T Cell Reactivity

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P55. In situ molecular assessment of CD8+ T cell reactivity in NSCLC

European Journal of Cancer Supplements ◽

10.1016/j.ejcsup.2006.04.115 ◽

2006 ◽

Vol 4 (6) ◽

pp. 47

Author(s):

A. Trojan ◽

M. Montemurro ◽

R.A. Stahel ◽

D. Jäger

Keyword(s):

T Cell ◽

Cd8 T Cell ◽

Cell Reactivity ◽

Molecular Assessment ◽

T Cell Reactivity

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Profound CD8 T cell responses towards the SARS-CoV-2 ORF1ab in COVID-19 patients

10.21203/rs.3.rs-33197/v1 ◽

2020 ◽

Cited By ~ 2

Author(s):

Anastasia Gangaev ◽

Steven L. C. Ketelaars ◽

Sanne Patiwael ◽

Anna Dopler ◽

Olga I. Isaeva ◽

...

Keyword(s):

T Cell ◽

T Cell Responses ◽

Cd8 T Cell ◽

T Cell Response ◽

Clinical Activity ◽

Cell Reactivity ◽

T Cell Recognition ◽

Cell Responses ◽

T Cell Reactivity ◽

Very High

Abstract A large global effort is currently ongoing to develop vaccines against SARS-CoV-2, the causative agent of COVID-19. While there is accumulating evidence on the antibody response against SARS-CoV-2, little is known about the SARS-CoV-2 antigens that are targeted by CD8 T cells. To address this issue, we have analyzed samples from 20 COVID-19 patients for T cell recognition of 500 predicted MHC class I epitopes. CD8 T cell reactivity against SARS-CoV- 2 was common. Remarkably, a substantial fraction of the observed CD8 T cell responses were directed towards the ORF1ab polyprotein 1ab, and these CD8 T cell responses were frequently of a very high magnitude. The fact that a major part of the SARS-CoV-2 specific CD8 T cell response is directed against a part of the viral genome that is not included in the majority of vaccine candidates currently in development may potentially influence their clinical activity and toxicity profile.

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