150 Predictive and/or diagnostic significance of serum soluble mesothelin related proteins (SMR) in asbestos-related pleural malignant mesothelioma: Follow-up of a large population of workers previously exposed to asbestos

Malignant pleural mesothelioma shows marked cytoarchitectural diversity. The aim of the study was to evaluate how morphological phenotype impacted upon overall survival. 191 cases of malignant pleural mesothelioma with available follow-up were identified, examined and classified according to histological types. The epithelioid mesotheliomas were further subdivided according to morphological subtypes: myxoid, microcystic, tubulopapillary, solid epithelioid, micropapillary and pleomorphic; biphasic mesotheliomas were divided into epithelioid component dominant and sarcomatoid component dominant; pure sarcomatoid mesotheliomas were divided into not otherwise specified, leiomyoid, desmoplastic and heterologous. All cases were confirmed by two experienced observers. Myxoid variant malignant pleural epithelioid mesothelioma was observed to have a favourable overall survival compared with pleomorphic form (p=0.00008). Pleomorphic phenotype had the worst overall survival. Morphological phenotype is an important histological factor that should be included in pathology reports to convey potential favourable prognostic subgroups of patients with mesothelioma.

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Incidence of Dilated Cardiomyopathy and Detection of HIV in the Myocardial Cells in a Large Population of HIV-positive Subjects: A Long-term Clinical and Echocardiographic Follow-up

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84182-4 ◽

1998 ◽

Vol 31 (2) ◽

pp. 109A-110A

Author(s):

G Barbaro

Keyword(s):

Dilated Cardiomyopathy ◽

Large Population ◽

Hiv Positive ◽

Myocardial Cells

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Stage IV Pleural Malignant Mesothelioma AJCC v7

10.32388/9dyxb9 ◽

2020 ◽

Author(s):

Keyword(s):

Malignant Mesothelioma ◽

Stage Iv ◽

Pleural Malignant Mesothelioma

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Does parental permissiveness toward cigarette smoking and alcohol use influence illicit drug use among adolescents? A longitudinal study in seven European countries

Social Psychiatry and Psychiatric Epidemiology ◽

10.1007/s00127-021-02118-5 ◽

2021 ◽

Author(s):

Emina Mehanović ◽

Federica Vigna-Taglianti ◽

Fabrizio Faggiano ◽

Maria Rosaria Galanti ◽

Barbara Zunino ◽

...

Keyword(s):

Alcohol Use ◽

Drug Use ◽

Cigarette Smoking ◽

Longitudinal Data ◽

Illicit Drug ◽

Large Population ◽

Illicit Drug Use ◽

European Countries ◽

The Impact

Abstract Purpose Adolescents’ perceptions of parental norms may influence their substance use. The relationship between parental norms toward cigarette and alcohol use, and the use of illicit substances among their adolescent children is not sufficiently investigated. The purpose of this study was to analyze this relationship, including gender differences, using longitudinal data from a large population-based study. Methods The present study analyzed longitudinal data from 3171 12- to 14-year-old students in 7 European countries allocated to the control arm of the European Drug Addiction Prevention trial. The impact of parental permissiveness toward cigarettes and alcohol use reported by the students at baseline on illicit drug use at 6-month follow-up was analyzed through multilevel logistic regression models, stratified by gender. Whether adolescents’ own use of cigarette and alcohol mediated the association between parental norms and illicit drug use was tested through mediation models. Results Parental permissive norms toward cigarette smoking and alcohol use at baseline predicted adolescents’ illicit drug use at follow-up. The association was stronger among boys than among girls and was mediated by adolescents’ own cigarette and alcohol use. Conclusion Perceived parental permissiveness toward the use of legal drugs predicted adolescents’ use of illicit drugs, especially among boys. Parents should be made aware of the importance of norm setting, and supported in conveying clear messages of disapproval of all substances.

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P24.05 Malignant Mesothelioma Related to Environmental Asbestos Exposure in a Rural Area: 30-year Follow-up

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2021.01.614 ◽

2021 ◽

Vol 16 (3) ◽

pp. S379

Author(s):

G. Ak ◽

S. Metintas ◽

E. Dundar ◽

M. Metintas

Keyword(s):

Rural Area ◽

Malignant Mesothelioma ◽

Asbestos Exposure

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Bioabsorbable Implant for Treatment of Nasal Valve Collapse with or without Concomitant Procedures

Facial Plastic Surgery ◽

10.1055/s-0041-1726464 ◽

2021 ◽

Author(s):

Douglas M. Sidle ◽

Pablo Stolovitzky ◽

Ellen M. O'Malley ◽

Randall A. Ow ◽

Nathan E. Nachlas ◽

...

Keyword(s):

Adverse Events ◽

Nasal Obstruction ◽

Large Population ◽

Inferior Turbinate ◽

Nasal Valve ◽

Serious Adverse Events ◽

Vas Scores ◽

Nasal Implant ◽

Nasal Valve Collapse

AbstractThe aim of the study is to report outcomes after treatment of nasal valve collapse with a bioabsorbable nasal implant. It involves two prospective, multicenter, post-market studies evaluating long-term effectiveness of the LATERA implant for severe to extreme nasal obstruction. Participants underwent implant alone or with concomitant inferior turbinate reduction (ITR) and/or septoplasty. Outcome measures included the change from baseline Nasal Obstruction Symptom Evaluation (NOSE) scores, NOSE responder rates, visual analog scale (VAS) scores, and adverse events. A total cohort of 277 participants (109 implants only, 67 implants + ITR, 101 implants + septoplasty + ITR) enrolled at 19 U.S. centers was available for analysis with 177 participants (69 implants only, 39 implants + ITR, 69 implants + septoplasty + ITR) available at 2 years. The mean changes from baseline in NOSE scores and VAS scores were statistically significant (p < 0.001) at all follow-up periods. The baseline NOSE score of 77.8 ± 13.6 was improved to 24.2 ± 23.6 at 24 months. Greater than 90% of participants were NOSE responders across all follow-up periods, 6.1% withdrew for lack of treatment effect. The baseline VAS score of 66.7 ± 18.8 was improved to 21.1 ± 23.9 at 24 months. There were no serious adverse events related to the device or implant procedure. Implant retrieval rate was 4.0% (22/543 implants). Nonserious adverse events were mild to moderate in severity, typically occurred within 6 months of implant, and resolved or were stable. Significant reductions in NOSE and VAS scores and high responder rates from our large population of patients with nasal obstruction who had nasal valve implants confirm sustained effectiveness at 24 months after treatment. The studies are registered on www.clinicaltrials.gov (NCT02952313 and NCT02964312).

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Immunogenetic Predictors of Severe COVID-19

Vaccines ◽

10.3390/vaccines9030211 ◽

2021 ◽

Vol 9 (3) ◽

pp. 211

Author(s):

Anna Malkova ◽

Dmitriy Kudlay ◽

Igor Kudryavtsev ◽

Anna Starshinova ◽

Piotr Yablonskiy ◽

...

Keyword(s):

Genetic Factors ◽

Virus Disease ◽

Analysis Data ◽

Published Data ◽

Diagnostic Significance ◽

Life Threatening ◽

Coronavirus Infection ◽

Angiotension Converting Enzyme ◽

Related Proteins

According to an analysis of published data, only 20% of patients with the new coronavirus infection develop severe life-threatening complications. Currently, there are no known biomarkers, the determination of which before the onset of the disease would allow assessing the likelihood of its severe course. The purpose of this literature review was to analyze possible genetic factors characterizing the immune response to the new coronavirus infection that could be associated with the expression of angiotension-converting enzyme 2 (ACE-2) and related proteins as predictors of severe Corona virus disease 2019 (COVID-19). We analyzed original articles published in Medline, PubMed and Scopus databases from December 2019 to November 2020. For searching articles, we used the following keywords: New coronavirus infection, Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), COVID-19, severe course, complications, thrombosis, cytokine storm, ACE-2, biomarkers. In total, 3714 publications were selected using the keywords, of which 8 were in congruence with all the criteria. The literature analysis of the association of immunogenic characteristics and the expression of ACE-2 and related proteins with the development of severe COVID-19 revealed following genetic factors: HLA-B*46:01 genotype, CXCR6 gene hypoexpression, CCR9 gene expression, TLR7, rs150892504 mutations in the ERAP2 gene, overexpression of wild-type ACE-2, TMPRSS2 and its different polymorphisms. Genes, associated with the severe course, are more common among men. According to the analysis data, it can be assumed that there are population differences. However, the diagnostic significance of the markers described must be confirmed with additional clinical studies.

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