The effect of dietary calcium content and oral vitamin D3 supplementation on mineral homeostasis in a subterranean mole-rat Cryptomys damarensis

A diet based on field peas and barley can satisfy the mineral requirements of growing pigs provided that calcium is supplemented at least to the level of dietary phosphorus present, and that vitamin D3 supplementation is greater than Agricultural Research Council recommendations. Bone fragility and lameness observed in pigs on a low calcium-low vitamin D3 diet was overcome by increasing either of these components, and this was accompanied by increased metacarpal ash and femur breaking strength. A similar response could also be produced by increasing dietary phosphorus levels. Plasma calcium and phosphate concentrations were significantly influenced by changes in the dietary calcium/phosphorus ratio, whereas vitamin D3 changes had a minimal influence. Parathyroid activity appeared to reflect the plasma calcium concentration. There did not appear to be any relationship between plasma concentrations and bone fragility or lameness.In order to ensure adequate bone development in pigs offered a diet of plant origin, vitamin D3 supplementation and elevation of dietary calcium to the level of total phosphorus present is a minimum requirement.

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Assessment of the efficacy of 400 IU of oral Vitamin D3 supplementation for term healthy breastfed Indian infants

Indian Journal of Child Health ◽

10.32677/ijch.2021.v08.i03.004 ◽

2021 ◽

Vol 8 (3) ◽

pp. 122-126

Author(s):

Kaifi Siddiqui ◽

Anwar Hasan Siddiqui ◽

Sheeba Farooqui ◽

Pradeep Kumar Ranbijuli

Keyword(s):

Vitamin D3 ◽

Oral Vitamin ◽

Vitamin D3 Supplementation

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Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis

Osteoporosis International ◽

10.1007/s00198-019-05102-7 ◽

2019 ◽

Vol 30 (11) ◽

pp. 2183-2193 ◽

Cited By ~ 6

Author(s):

N. Charoenngam ◽

P. Rujirachun ◽

M.F. Holick ◽

P. Ungprasert

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Vitamin D3 ◽

Meta Analysis ◽

Fibroblast Growth Factor 23 ◽

Fibroblast Growth ◽

Oral Vitamin ◽

Vitamin D3 Supplementation

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Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

Nutrients ◽

10.3390/nu13072170 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2170

Author(s):

Shaun Sabico ◽

Mushira A. Enani ◽

Eman Sheshah ◽

Naji J. Aljohani ◽

Dara A. Aldisi ◽

...

Keyword(s):

Clinical Trial ◽

Vitamin D ◽

Randomized Clinical Trial ◽

Vitamin D3 ◽

Sensory Loss ◽

Vitamin D Status ◽

Oral Vitamin ◽

Increased Risk ◽

Vitamin D3 Supplementation ◽

Group Comparisons

Objective: Vitamin D deficiency has been associated with an increased risk of COVID-19 severity. This multi-center randomized clinical trial aims to determine the effects of 5000 IU versus 1000 IU daily oral vitamin D3 supplementation in the recovery of symptoms and other clinical parameters among mild to moderate COVID-19 patients with sub-optimal vitamin D status. Study Design and Setting: A total of 69 reverse transcriptase polymerase chain reaction (RT-PCR) SARS-CoV-2 positive adults who were hospitalized for mild to moderate COVID-19 disease were allocated to receive once daily for 2 weeks either 5000 IU oral vitamin D3 (n = 36, 21 males; 15 females) or 1000 IU oral vitamin D3 (standard control) (n = 33, 13 males; 20 females). Anthropometrics were measured and blood samples were taken pre- and post-supplementation. Fasting blood glucose, lipids, serum 25(OH)D, and inflammatory markers were measured. COVID-19 symptoms were noted on admission and monitored until full recovery. Results: Vitamin D supplementation for 2 weeks caused a significant increase in serum 25(OH)D levels in the 5000 IU group only (adjusted p = 0.003). Within-group comparisons also showed a significant decrease in BMI and IL-6 levels overtime in both groups (p-values < 0.05) but was not clinically significant in between-group comparisons. Kaplan–Meier survival analysis revealed that the 5000 IU group had a significantly shorter time to recovery (days) than the 1000 IU group in resolving cough, even after adjusting for age, sex, baseline BMI, and D-dimer (6.2 ± 0.8 versus 9.1 ± 0.8; p = 0.039), and ageusia (loss of taste) (11.4 ± 1.0 versus 16.9 ± 1.7; p = 0.035). Conclusion: A 5000 IU daily oral vitamin D3 supplementation for 2 weeks reduces the time to recovery for cough and gustatory sensory loss among patients with sub-optimal vitamin D status and mild to moderate COVID-19 symptoms. The use of 5000 IU vitamin D3 as an adjuvant therapy for COVID-19 patients with suboptimal vitamin D status, even for a short duration, is recommended.

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The efficacy of vitamin D3 supplementation in increasing 25-hydroxyvitamin D levels in childhood vitiligo patients receiving 308-nm-excimer light phototherapy

Dermatology Reports ◽

10.4081/dr.2019.8049 ◽

2019 ◽

Author(s):

Reiva Farah Dwiyana ◽

Pramita K.C. Nugrahaini ◽

D.P. Larasati ◽

Inne Arline Diana ◽

Reti Hindritiani ◽

...

Keyword(s):

Vitamin D ◽

Combination Therapy ◽

Vitamin D3 ◽

Vitamin D Supplementation ◽

Oral Vitamin ◽

Once Daily ◽

Hydroxyvitamin D ◽

Group I ◽

Vitamin D3 Supplementation ◽

25 Hydroxyvitamin D

Vitamin D deficiency is a condition often found in various autoimmune diseases, including vitiligo. There were clinical improvements in autoimmune patients who had been given oral vitamin D supplementation, as well as vitiligo patients. This study aimed to analyze the comparison effect of a combination therapy of 308-nmexcimer light phototherapy and vitamin D3 supplementation toward 308-nm-excimer light phototherapy alone to increase of serum 25-(OH)D levels in childhood vitiligo patients. Subjects consisted of 16 childhood vitiligo patients that divided into two groups; group I was given a combination of 308-nm-excimer light phototherapy and 5000 IU of vitamin D3 supplement once daily, while group II was given monotherapy of excimer light. There were highly significant increase of 25-(OH)D serum in both groups which were 324.00±119.066% and 29.84±36.106%, respectively. The very significant result was seen in a comparison of average increased of serum 25-(OH)D levels between both groups. The study concluded that combination of 308-nm-excimer light phototherapy and vitamin D3 supplementation gave a better effect than phototherapy only to increase of serum 25- (OH)D levels in childhood vitiligo patients.

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