Fibrous papule: An immunohistochemical study with an antibody to S-100 protein

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

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Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature

International Journal of Dentistry ◽

10.1155/2009/143460 ◽

2009 ◽

Vol 2009 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Kayo Kuyama ◽

Sisilia Fusi Fifita ◽

Masamichi Komiya ◽

Yan Sun ◽

Yoshiaki Akimoto ◽

...

Keyword(s):

Oral Cavity ◽

Immunohistochemical Study ◽

Fat Cells ◽

Fatty Tissue ◽

Review Of The Literature ◽

Woven Bone ◽

Osteoid Tissue ◽

Spindle Cells ◽

S 100 ◽

Lipomatous Tumors

The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 & and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

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S-100 protein: an immunohistochemical study of fetal eccrine sweat glands and of sweat gland adenomas

Immunodermatology ◽

10.1016/b978-0-407-00338-5.50021-1 ◽

1984 ◽

pp. 65-70 ◽

Cited By ~ 1

Author(s):

N.S. Penneys ◽

M. Nadji ◽

B.E. Buck ◽

R. Kott-Blumenkranz

Keyword(s):

Sweat Gland ◽

Immunohistochemical Study ◽

Sweat Glands ◽

S 100 ◽

Eccrine Sweat Glands ◽

Eccrine Sweat

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Dual Immunologic Property of S-100 Protein in Normal Eyes and Eyes with Retinoblastoma: A Histopathological and Immunohistochemical Study of 88 Cases

Ophthalmologica ◽

10.1159/000310378 ◽

1993 ◽

Vol 206 (3) ◽

pp. 133-138 ◽

Cited By ~ 2

Author(s):

Wei He ◽

Hajime Inomata

Keyword(s):

Immunohistochemical Study ◽

S 100

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Atypical Polypoid Adenomyoma of the Uterus. An Immunohistochemical Study of a Case

Tumori Journal ◽

10.1177/030089168907500322 ◽

1989 ◽

Vol 75 (3) ◽

pp. 292-295 ◽

Cited By ~ 7

Author(s):

Silvana Di Palma ◽

Donatella Santini ◽

Giuseppe Martinelli

Keyword(s):

Differential Diagnosis ◽

Stromal Cells ◽

Immunohistochemical Study ◽

Invasive Adenocarcinoma ◽

S 100 ◽

Atypical Polypoid Adenomyoma

We studied one case of atypical polypoid adenomyoma of the uterus immunohistochemically using antisera against keratins, vimentin, S-100 protein, desmin and actin. The stromal cells were reactive with anti-actin and antidesmin antibodies suggesting a muscular phenotype and confirming previous ultrastructural data. Immunohistochemical investigations have proved to be useful in differential diagnosis of APA with invasive adenocarcinoma, adenosarcoma and adenofibroma of the endometrium.

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