P2-212 Age-related cortical grey matter reductions in nondemented down's syndrome adults determined by magnetic resonance imaging with voxel-based morphometry

2004 ◽  
Vol 25 ◽  
pp. S290 ◽  
Author(s):  
Stefan J. Teipel ◽  
Gene E. Alexander ◽  
Marc B. Schapiro ◽  
Hans-Jürgen Möller ◽  
Stanley I. Rapoport ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Grey Matter ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Voxel Based Morphometry ◽  
Resonance Imaging ◽  
Age Related ◽  
Cortical Grey Matter

scholarly journals Age‐related cortical grey matter reductions in non‐demented Down’s syndrome adults determined by MRI with voxel‐based morphometry

Brain ◽  
2004 ◽  
Vol 127 (4) ◽  
pp. 811-824 ◽  
Author(s):  
Stefan J. Teipel ◽  
Gene E. Alexander ◽  
Marc B. Schapiro ◽  
Hans‐Jürgen Möller ◽  
Stanley I. Rapoport ◽  
...  
Keyword(s):  
Grey Matter ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Voxel Based Morphometry ◽  
Age Related ◽  
Cortical Grey Matter

Clinical use of structural magnetic resonance imaging in the diagnosis of dementia in adults with Down's syndrome

2002 ◽  
Vol 19 (2) ◽  
pp. 60-63 ◽  
Author(s):  
Andre Strydom ◽  
Angela Hassiotis ◽  
Zuzana Walker
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Practice ◽  
Magnetic Resonance ◽  
Current Knowledge ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Brain Structures ◽  
Future Research ◽  
Resonance Imaging ◽  
Mri Studies

AbstractObjectives: Magnetic Resonance Imaging (MRI) has been used to assist the diagnosis of Alzheimer's Disease (AD) in adults with Down's syndrome (DS). However, the interpretation of the scans is difficult and clinical usefulness is uncertain. We aimed to summarise the current knowledge of MRI studies in adults with Down's syndrome with and without dementia and to discuss its implications for clinical practice.Method: We identified MRI studies in DS by a computerised literature search with Medline, Embase, and Psychlit from 1986 to 2001. We examined the references of identified articles and hand searched relevant journals. Structural MRI studies were selected as this type of imaging is most frequently used in clinical practice.Results: We included eight volumetric studies in adults with DS. Four of these included adults with DS and dementia. Overall, the size of brain structures such as cerebellum, hippocampus and cortex of adults with DS without dementia was significantly smaller than in normal controls. The basal ganglia were similar in size, and ventricles were enlarged. Furthermore, the size of brain structures in adults with DS and dementia was significantly different than in DS without dementia. In particular, ventricular and hippocampal volumes were affected.Conclusions: The change in brain structure associated with dementia can be detected on MRI of adults with DS. However, these may be difficult to interpret given the extent to which brain appearance in DS differs from that in the general population. Implications for clinical practice and future research directions are discussed.

scholarly journals Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry

2006 ◽  
Vol 188 (5) ◽  
pp. 484-485 ◽  
Author(s):  
Andrea G. Ludolph ◽  
Freimut D. Juengling ◽  
Gerhard Libal ◽  
Albert C. Ludolph ◽  
Jörg M. Fegert ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tourette Syndrome ◽  
Grey Matter ◽  
Imaging Study ◽  
Hippocampal Volume ◽  
Data Sets ◽  
Imaging Data ◽  
Voxel Based Morphometry ◽  
Resonance Imaging

SummaryThe genesis of Tourette syndrome is still unknown, but a core role for the pathways of cortico-striatal-thalamic-cortical circuitry (CSTC) is supposed. Volume-rendering magnetic resonance imaging data-sets were analysed in 14 boys with Tourette syndrome and 15 age-matched controls using optimised voxel-based morphometry. Locally increased grey-matter volumes (corrected P < 0.001) were found bilaterally in the ventral putamen. Regional decreases in grey matter were observed in the left hippocampal gyrus. This unbiased analysis confirmed an association between striatal abnormalities and Tourette syndrome, and the hippocampal volume alterations indicate an involvement of temporolimbic pathways of the CSTC in the syndrome.

Advanced magnetic resonance imaging of neuromyelitis optica: a multiparametric approach

2011 ◽  
Vol 18 (6) ◽  
pp. 817-824 ◽  
Author(s):  
A Pichiecchio ◽  
E Tavazzi ◽  
G Poloni ◽  
M Ponzio ◽  
F Palesi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Grey Matter ◽  
Diffusion Tensor ◽  
Healthy Controls ◽  
Voxel Based Morphometry ◽  
Resonance Imaging ◽  
Normal Appearing White Matter

Background: Several authors have used advanced magnetic resonance imaging (MRI) techniques to investigate whether patients with neuromyelitis optica (NMO) have occult damage in normal-appearing brain tissue, similarly to multiple sclerosis (MS). To date, the literature contains no data derived from the combined use of several advanced MRI techniques in the same NMO subjects. Objective: We set out to determine whether occult damage could be detected in the normal-appearing brain tissue of a small group of patients with NMO using a multiparametric MRI approach. Methods: Eight female patients affected by NMO (age range 44–58 years) and seven sex- and age-matched healthy controls were included. The techniques used on a 1.5 T MRI imaging scanner were magnetization transfer imaging, diffusion tensor imaging, tract-based spatial statistics, spectroscopy and voxel-based morphometry in order to analyse normal-appearing white matter and normal-appearing grey matter. Results: Structural and metabolic parameters showed no abnormalities in normal-appearing white matter of patients with NMO. Conversely, tract-based spatial statistics demonstrated a selective alteration of the optic pathways and the lateral geniculate nuclei. Diffusion tensor imaging values in the normal-appearing grey matter were found to be significantly different in the patients with NMO versus the healthy controls. Moreover, voxel-based morphometry analysis demonstrated a significant density and volume reduction of the sensorimotor cortex and the visual cortex. Conclusions: Our data disclosed occult structural damage in the brain of patients with NMO, predominantly involving regions connected with motor and visual systems. This damage seems to be the direct consequence of transsynaptic degeneration triggered by lesions of the optic nerve and spine.

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