High Fluoride Exposure in Hemodialysis Patients

Due to practical difficulties in quantifying fluoride exposure, the ability of various biomarkers to predict exposure has been investigated previously. However, the results are inadequate for validation of their application and usefulness. This study aimed to investigate the association between contemporary/recent biomarkers of fluoride exposure and total daily fluoride intake (TDFI) of children with large differences in fluoride exposure through drinking water. TDFI was assessed in 61 healthy 4- to 5-year-old children who provided at least 1 biomarker sample; 32 lived in a low-fluoride area (0.04 mg F/L) and 29 lived in a high-fluoride area (3.05 mg F/L). Validated questionnaires were administered to evaluate fluoride intake from diets (including water) and toothpaste ingestion. Daily urinary fluoride excretion (UFE) and fluoride concentrations in plasma, fasting whole saliva, hair, and nails (toenails/fingernails) were evaluated and related to total fluoride exposure. TDFI, UFE, and fluoride concentrations of biomarkers were statistically significantly higher in the high-fluoride area than in the low-fluoride area. There was a strong statistically significant positive correlation between TDFI and UFE (ρ = 0.756, p < 0.001); plasma fluoride concentration (ρ = 0.770, p < 0.001); and toenail fluoride concentration (ρ = 0.604, p < 0.001). The statistically significant positive correlation between TDFI and fingernail fluoride concentration (ρ = 470, p < 0.001) as well as between TDFI and fasting whole saliva fluoride concentration (ρ = 0.453, p = 0.001) was moderate, whereas it was weak between TDFI and hair fluoride concentration (ρ = 0.306, p = 0.027). In conclusion, the current study confirmed the suitability of 24-h urine samples for estimating fluoride exposure in children. The strong correlations between TDFI and fluoride in plasma and toenails also suggest these biomarkers may be considered for health risk assessments of fluoride in children who are susceptible to development of dental fluorosis.

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Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2021.113006 ◽

2021 ◽

Vol 228 ◽

pp. 113006

Author(s):

Jinge Xin ◽

Ning Sun ◽

Hesong Wang ◽

Hailin Ma ◽

Bangyuan Wu ◽

...

Keyword(s):

Network Analysis ◽

Renal Injury ◽

Lactobacillus Johnsonii ◽

Colonic Microbiota ◽

Fluoride Exposure ◽

High Fluoride ◽

Preventive Effects

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Preliminary Evidence of an Association Between COL1A2 Polymorphisms and Dental Fluorosis in a Population with High Fluoride Exposure

Journal of Evidence Based Dental Practice ◽

10.1016/j.jebdp.2010.02.007 ◽

2010 ◽

Vol 10 (2) ◽

pp. 96-98 ◽

Cited By ~ 2

Author(s):

Deborah V. Dawson

Keyword(s):

Dental Fluorosis ◽

Preliminary Evidence ◽

Fluoride Exposure ◽

High Fluoride

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Quantitative Assessment of HCV Load in Chronic Hemodialysis Patients

Infection Control and Hospital Epidemiology ◽

10.1017/s0195941700070004 ◽

1999 ◽

Vol 20 (02) ◽

pp. 123

Author(s):

Gina Pugliese ◽

Martin S. Favero

Keyword(s):

Quantitative Assessment ◽

Hemodialysis Patients ◽

Chronic Hemodialysis

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A cost effective decision analysis model comparing two strategies for maintaining hepalitis B immunity in hemodialysis patients

Gastroenterology ◽

10.1016/s0016-5085(01)82763-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A556-A556

Author(s):

S WESTON ◽

S SAAB ◽

D LY ◽

M BREZINA ◽

H YEE ◽

...

Keyword(s):

Decision Analysis ◽

Cost Effective ◽

Hemodialysis Patients ◽

Decision Analysis Model ◽

Analysis Model ◽

Effective Decision

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Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000604 ◽

2019 ◽

pp. 1-7

Author(s):

Hadeer Zakaria ◽

Tarek M. Mostafa ◽

Gamal A. El-Azab ◽

Nagy AH Sayed-Ahmed

Keyword(s):

Fatty Acids ◽

Vitamin E ◽

Fish Oil ◽

Wheat Germ ◽

Hemodialysis Patients ◽

Nutritional Indices ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Wheat Germ Oil ◽

Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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