scholarly journals Biomarkers for the Assessment of Fluoride Exposure in Children

2020 ◽  
Vol 54 (2) ◽  
pp. 134-143
Author(s):  
Oladipo S. Idowu ◽  
Ralph M. Duckworth ◽  
Ruth A. Valentine ◽  
Fatemeh Vida Zohoori
Keyword(s):  
Significant Positive Correlation ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Strong Correlations ◽  
Positive Correlation ◽  
Validated Questionnaires ◽  
Fluoride Exposure ◽  
Fluoride Intake ◽  
Whole Saliva ◽  
High Fluoride

Due to practical difficulties in quantifying fluoride exposure, the ability of various biomarkers to predict exposure has been investigated previously. However, the results are inadequate for validation of their application and usefulness. This study aimed to investigate the association between contemporary/recent biomarkers of fluoride exposure and total daily fluoride intake (TDFI) of children with large differences in fluoride exposure through drinking water. TDFI was assessed in 61 healthy 4- to 5-year-old children who provided at least 1 biomarker sample; 32 lived in a low-fluoride area (0.04 mg F/L) and 29 lived in a high-fluoride area (3.05 mg F/L). Validated questionnaires were administered to evaluate fluoride intake from diets (including water) and toothpaste ingestion. Daily urinary fluoride excretion (UFE) and fluoride concentrations in plasma, fasting whole saliva, hair, and nails (toenails/fingernails) were evaluated and related to total fluoride exposure. TDFI, UFE, and fluoride concentrations of biomarkers were statistically significantly higher in the high-fluoride area than in the low-fluoride area. There was a strong statistically significant positive correlation between TDFI and UFE (ρ = 0.756, p < 0.001); plasma fluoride concentration (ρ = 0.770, p < 0.001); and toenail fluoride concentration (ρ = 0.604, p < 0.001). The statistically significant positive correlation between TDFI and fingernail fluoride concentration (ρ = 470, p < 0.001) as well as between TDFI and fasting whole saliva fluoride concentration (ρ = 0.453, p = 0.001) was moderate, whereas it was weak between TDFI and hair fluoride concentration (ρ = 0.306, p = 0.027). In conclusion, the current study confirmed the suitability of 24-h urine samples for estimating fluoride exposure in children. The strong correlations between TDFI and fluoride in plasma and toenails also suggest these biomarkers may be considered for health risk assessments of fluoride in children who are susceptible to development of dental fluorosis.

scholarly journals Fluorosis in rats exposed to oscillating chronic fluoride doses

2010 ◽  
Vol 21 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Danilo Bonadia Catani ◽  
Livia Maria Andaló Tenuta ◽  
Fernanda Alcântara Andaló ◽  
Jaime Aparecido Cury
Keyword(s):  
Image Analysis ◽  
Research Group ◽  
Quantitative Method ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Experimental Period ◽  
Metabolic Effect ◽  
Fluoride Exposure ◽  
Constant Dose ◽  
The Mean

Considering that blood fluoride concentration varies according to fluoride exposure and that dental fluorosis is related to the amount of enamel formed under a given fluoride dose, the present study investigated whether the fluorosis produced by an oscillating chronic fluoride dose would be similar to that caused by exposure to a constant dose, representing the mean of the oscillation during a given time. Rats received during 78 days water with fluoride concentrations of 0, 12.5, 25 or 37.5 µg F/mL, or oscillating concentrations of 12.5 and 37.5 µg F/mL every 72 h (mean exposure=25 µg F/mL). The concentrations of fluoride in the plasma, femur and incisors of the rats were determined at the end of the experimental period. Also, the enamel dental fluorosis index was determined in the incisors using a quantitative method developed by our research group named Dental Fluorosis by Image Analysis (DFIA). Fluoride concentrations in plasma, femur and teeth, and DFIA increased linearly for constant fluoride concentrations in water (p<0.0001, r values=0.87-0.98). The results of the oscillating group and the groups receiving 25 µg F/mL did not differ significantly (p>0.05). The findings of this study suggest that in animals chronically exposed to symmetrically oscillating fluoride doses, the resulting dental fluorosis reflects the metabolic effect of the mean of the oscillating doses.

scholarly journals Evaluation of Physicochemical Characteristics in Drinking Water Sources Emphasized on Fluoride: A Case Study of Yancheng, China

2019 ◽  
Vol 16 (6) ◽  
pp. 1030 ◽  
Author(s):  
Yumin Wang ◽  
Ran Yu ◽  
Guangcan Zhu
Keyword(s):  
Cluster Analysis ◽  
Factor Analysis ◽  
Drinking Water ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Water Sources ◽  
Total Alkalinity ◽  
Drinking Water Sources ◽  
Fluoride Exposure ◽  
Exposure Levels

In this study, the concentration of fluoride and the associated health risks for infants, children, and adults were analyzed and compared for three drinking water sources in Yancheng City, Jiangsu Province, China. To analyze the relationship between the water quality parameters of pH, fluoride (F−), sulfate (SO42−), chloride (Cl−), total dissolved solids (TDS), total alkalinity (TAlk), sodium (Na+), and potassium (K+), statistical analyses including correlation analysis, R-mode cluster analysis and factor analysis were performed based on monthly data from the year 2010 to 2015. The results indicated: (1) Fluoride concentrations in the drinking water sources ranged from 0.38 to 1.00 mg L−1 (mean = 0.57 mg L−1) following the order of Tongyu River > Yanlong Lake > Mangshe River; (2) fluoride concentrations in 22.93% of the collected samples were lower than 0.5 mg L−1, which has the risk of tooth cavities, especially for the Mangshe River; (3) the fluoride exposure levels of infants were higher than children and adults, and 3.2% of the fluoride exposure levels of infants were higher than the recommended toxicity reference value of 122 μg kg−1 d−1 as referenced by Health Canada, which might cause dental fluorosis issues; (4) the physico-chemical characteristics are classified the into four groups reflecting F−- TAlk, Na+-K+, SO42−-Cl−, and pH-TDS, respectively, indicating that fluoride solubility in drinking water is TAlk dependent, which is also verified by R-mode cluster analysis and factor analysis. The results obtained supply useful information for the health department in Yancheng City, encouraging them to pay more attention to fluoride concentration and TAlk in drinking water sources.

Salt Fluoridation and General Health

1995 ◽  
Vol 9 (2) ◽  
pp. 138-143 ◽  
Author(s):  
K.E. Bergmann ◽  
R.L. Bergmann
Keyword(s):  
Drinking Water ◽  
Salt Intake ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Mineral Waters ◽  
Table Salt ◽  
Fluoride Level ◽  
Individual Level ◽  
Salt Consumption ◽  
Fluoride Intake

Salt fluoridation is a systemic form of fluoride supplementation, leaving it to the consumer whether he wants fluoride supplements or not, but thereafter not requiring special dependability for daily compliance. Most German drinking water has low fluoride concentrations. The estimated fluoride intake in German children is between 100 and 300 μg/day, and in adults, between 400 and 600 μg/day. Male subjects have higher mean intakes than females. From 70 to 90% of the salt intake of 10 to 13.5 g/day in German adults comes from commercially prepared foods. This leaves about 1 to 4 g of salt to be added as table salt at the individual level and to become the source of supplementary fluoride. To increase fluoride intake by at least 500 μg/d, and to prevent an additional intake of more than 3000 μg/day, it may be necessary to have salt at a fluoride level of around 500 μg/g or to include one commercial food to be prepared with fluoridated salt, e.g., bread. A salt fluoride concentration of 250 μg/g does not present a risk of dental fluorosis. However, clear recommendations about systemic fluoride supplementation must be given as long as there are fluoride tablets, fluoride-rich mineral waters, and fluoridated table salt available simultaneously. Persons at risk for hypertension from salt consumption require different means of fluoride supplementation. By and large, in areas of low drinking water fluoride, fluoridated table salt has the potential to become a means of systemic supplementation comparable with drinking water fluoridation.

Ultrastructure and Composition of Enamel in Human Dental Fluorosis

1989 ◽  
Vol 3 (2) ◽  
pp. 203-210 ◽  
Author(s):  
T. Yanagisawa ◽  
S. Takuma ◽  
O. Fejerskov
Keyword(s):  
Surface Layer ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Occlusal Caries ◽  
Electron Microscopic ◽  
High Fluoride Concentration ◽  
High Fluoride ◽  
Materials Used ◽  
High Degree ◽  
Hexagonal Crystals

Materials used in this work were 13 permanent molars exhibiting dental fluorosis (between 5 and 9 on the Thylstrup-Fejerskov scale, 1978) obtained from adults (aged 20-40 years) living in regions with 3.5 ppm fluoride in the water supplies. Small but deep occlusal caries lesions necessitated extraction. Light and polarized microscopic, microradiographic, electron microscopic, and electron-probe- and ion-micro-analytical studies were made. Enamel surfaces were generally cloudy to opaque, with several pits or defects of various sizes and degrees of brown-staining. An extensively hypomineralized area extended from the inner enamel to the surface layer, which was mineralized to a high degree. The hypomineralized area contained sparsely arranged, flattened, hexagonal crystals with either perforated centers or defects extending from the perimeter and indicating either no or low fluoride content. The highly mineralized surface layer, however, was composed of many large, flattened, hexagonal crystals and extremely small, irregularly shaped crystals. Both types were free of central perforations and defects. A high fluoride concentration was determined in the highly mineralized surface layer. These findings suggest that the hypomineralized area undergoes caries-like changes in terms of crystal dissolution and that the highly mineralized surface layer contains hydroxyapatite and fluoridated-hydroxyapatite, or fluorapatite, or both.

scholarly journals Association between Urine Fluoride and Dental Fluorosis as a Toxicity Factor in a Rural Community in the State of San Luis Potosi

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Lizet Jarquín-Yañez ◽  
José de Jesús Mejía-Saavedra ◽  
Nelly Molina-Frechero ◽  
Enrique Gaona ◽  
Diana Olivia Rocha-Amador ◽  
...  
Keyword(s):  
Rural Community ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
The State ◽  
High Positive Correlation ◽  
Fluoride Exposure ◽  
San Luis ◽  
San Luis Potosi ◽  
Toxicity Factor ◽  
San Luis Potosí

Objective. The aim of this study is to investigate urine fluoride concentration as a toxicity factor in a rural community in the state of San Luis Potosi, Mexico.Materials and Methods. A sample of 111 children exposed to high concentrations of fluoride in drinking water (4.13 mg/L) was evaluated. Fluoride exposure was determined by measuring urine fluoride concentration using the potentiometric method with an ion selective electrode. The diagnosis of dental fluorosis was performed by clinical examination, and the severity of damage was determined using Dean’s index and the Thylstrup-Fejerskov (TF) index.Results. The range of exposure in the study population, evaluated through the fluoride content in urine, was 1.1 to 5.9 mg/L, with a mean of 3.14 ± 1.09 mg/L. Dental fluorosis was present in all subjects, of which 95% had severe cases. Higher urine fluoride levels and greater degrees of severity occurred in older children.Conclusions. The results show that dental fluorosis was determined by the presence of fluoride exposure finding a high positive correlation between the severity of fluorosis and urine fluoride concentration and the years of exposure suggested a cumulative effect.

scholarly journals FLUORIDE IN GROUNDWATER AND ITS EFFECTS ON HUMAN HEALTH

2017 ◽  
Vol 6 (2) ◽  
pp. 51 ◽  
Author(s):  
Ayse Dilek ATASOY ◽  
Mehmet İrfan YEŞİLNACAR ◽  
Benan YAZICI ◽  
Müge ÖZDEMİR ŞAHİN
Keyword(s):  
Human Health ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
World Health ◽  
Negative Effects ◽  
School Students ◽  
The World ◽  
High Fluoride ◽  
Permissible Levels ◽  
Recommended Level

Fluoride contents higher than the permissible levels lead to negative effects on the human health. More than 200 million people in the world were adversely affected from the fluoride. Fluoride levels in water were higher than the World Health Organization’s (WHO) recommended level. Endemic fluorosis originating from the consumption of high fluorine water was observed also in some parts of Anatolia. Volcanic formations are found in areas with high fluoride concentrations in ground waters. In this study, fluoride concentration of water was researched in Şanlıurfa where comprised generally sedimental formations and where the fluorosis cases were identified on the primary school students. High fluoride levels were assigned in water samples from the wells in Sarım and Karataş villages in Şanlıurfa. Keywords: Fluoride, hydrogeochemistry, dental fluorosis, Şanlıurfa   

scholarly journals ASSESSMENT OF DENTAL FLUOROSIS IN CHILDREN OF JAIPUR DISTRICT, RAJASTHAN, INDIA

2017 ◽  
Vol 10 (8) ◽  
pp. 161
Author(s):  
Chetram Meena ◽  
Suman Rathore ◽  
Supriya Dwivedi ◽  
Zaozianlungliu Gonmei ◽  
Toteja Gs ◽  
...  
Keyword(s):  
Drinking Water ◽  
Risk Factor ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Study Finding ◽  
Hand Pump ◽  
Potential Association ◽  
High Fluoride ◽  
Tube Well

Objective: The objective of the present study was carried out to explore the potential association between fluoride concentration in drinking water and severity of dental fluorosis (DF) in the children.Methods: The study of dental fluorosis (DF) in the children (6-14 years old) was conducted in the two blocks (a) Jamwaramgarh block ;Heerawala, Palera ,Nayabas, Saipur and Birasana, (b) Amber block; Jugalpura, Chitanukalan, Sunder ka bas, Peelwa and Sirsali of Jaipur district, Rajasthan, India of the study villages. Total 150, children were surveyed. The role of fluoride (F) levels in drinking water in the etiology of dental fluorosis (DF) and the cases of dental fluorosis (DF) in both dentitions and teeth were also assessed using DEAN’S classification. The fluoride (F) concentration in source of drinking water was estimated by fluoride (F) ion specific electrode (Thermo Scientific Orion Star A329, USA).Results: The F concentration in (Tube well and Hand pump) water ranges from 0.7 to 15.0 parts per million (ppm) in Jamwaramgarh block and 1.40 to 5. 10 parts per million (ppm) in Amber block. Prevalence of dental fluorosis (DF) 27 (36%) in Jamwaramgar block and 26 (34.66%) in Amber block out of 75 children were examined in each block. Significantly increase in levels of F in drinking water is positively correlated with dental fluorosis.Conclusion: This study finding has shown the relation of dental fluorosis (DF) to high fluoride (F) levels in drinking water sources. A higher fluoride (F) levels in source of drinking water is a major risk factor for dental fluorosis. In view of the severity of the problem the intake of calcium rich foods and defluoridation techniques may help reducing risk of dental fluorosis (DF) in the children. 

scholarly journals Fluoride Concentration in Ground Water and Prevalence of Dental Fluorosis in Ethiopian Rift Valley: Systematic Review and Meta-Analysis

2019 ◽  
Author(s):  
Habtamu Demelash Enyew ◽  
Abebe Hailu Beyene ◽  
Zewdu Abebe ◽  
Addisu Dagnaw Melese
Keyword(s):  
Drinking Water ◽  
Ground Water ◽  
Rift Valley ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Ethiopian Rift ◽  
Pooled Prevalence ◽  
High Fluoride ◽  
The Mean ◽  
Mean Concentration

Abstract Background High fluoride concentrations in ground water is a serious health, social and economic problem in developing countries. The Ethiopian Rift Valley is associated with high fluoride levels in ground water where deep wells are the major source of drinking water supply. Many epidemiological studies on fluoride concentration and its adverse effects have been carried out. However, the result is scattered in different studies which needs systematically summarized for utilization.Objective The aim of this research is to estimate the pooled level of fluoride concentration in ground water and the prevalence of dental fluorosis in Ethiopian rift valley.Methods MEDLINE/PubMed, Cochrane library and Google scholar databases were systematically searched for studies reporting the mean concentration of fluoride in ground water and prevalence of dental fluorosis in Ethiopian Rift valley. We identified search terms by extracting key terms from reviews and selected relevant papers and review medical subject headings for relevant and appropriate terms.Results The mean concentration of fluoride in ground water and the prevalence of dental fluorosis were pooled from eleven and nine primary studies conducted in Ethiopian Rift Valley respectively. The pooled mean concentration of fluoride in ground water therefore was 6.03 mg/l (95% CI; 4.72–7.72, p < 0.001) and the pooled prevalence of dental fluorosis among residents in Ethiopian rift valley was 32% (95% CI: 25, 39%, p<0.001), 29% (95% CI: 22, 36%, p<0.001) and 24% (95% CI: 17, 32%, p<0.001 for mild, moderate and sever fluorosis respectively. The overall prevalence of dental fluorosis is 28% (95% CI: 24, 32%, p<0.001).Conclusions The mean concentration of fluoride in ground water in Ethiopian rift valley is nearly four times greater than the WHO guideline (1.5mg/l). Relatively high-level pooled prevalence of dental fluorosis was also seen in Ethiopian rift valley. Therefore, further studies covering the temperature, exposure time and other intake path ways including diet with large sample size is recommended. Interventional projects should conduct to decrease the concentration of fluoride in the ground drinking water source.

Fluoride Revolution and Dental Caries: Evolution of Policies for Global Use

2019 ◽  
Vol 98 (8) ◽  
pp. 837-846 ◽  
Author(s):  
H.P. Whelton ◽  
A.J. Spencer ◽  
L.G. Do ◽  
A.J. Rugg-Gunn
Keyword(s):  
Dental Caries ◽  
Public Perception ◽  
Tooth Development ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Caries Prevention ◽  
World Health ◽  
Caries Experience ◽  
Water Fluoridation ◽  
Fluoride Exposure

Epidemiological studies over 70 y ago provided the basis for the use of fluoride in caries prevention. They revealed the clear relation between water fluoride concentration, and therefore fluoride exposure, and prevalence and severity of dental fluorosis and dental caries. After successful trials, programs for water fluoridation were introduced, and industry developed effective fluoride-containing toothpastes and other fluoride vehicles. Reductions in caries experience were recorded in many countries, attributable to the widespread use of fluoride. This is a considerable success story; oral health for many was radically improved. While previously, water had been the only significant source of fluoride, now there are many, and this led to an increase in the occurrence of dental fluorosis. Risks identified for dental fluorosis were ingestion of fluoride-containing toothpaste, water fluoridation, fluoride tablets (which were sometimes ingested in areas with water fluoridation), and infant formula feeds. Policies were introduced to reduce excessive fluoride exposure during the period of tooth development, and these were successful in reducing dental fluorosis without compromising caries prevention. There is now a much better understanding of the public perception of dental fluorosis, with mild fluorosis being of no aesthetic concern. The advantages of water fluoridation are that it provides substantial lifelong caries prevention, is economic, and reduces health inequalities: it reaches a substantial number of people worldwide. Fluoride-containing toothpastes are by far the most important way of delivering the beneficial effect of fluoride worldwide. The preventive effects of conjoint exposure (e.g., use of fluoride toothpaste in a fluoridated area) are additive. The World Health Organization has informed member states of the benefits of the appropriate use of fluoride. Many countries have policies to maximize the benefits of fluoride, but many have yet to do so.

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