Clinical Syndromes Associated with Bicycle Seats

Human parechoviruses (HPeV) belonging to the family Picornaviridae are widespread enteric pathogens and are associated with various clinical syndromes in human. At present, 16 HPeV genotypes (HPeV1–16) are known. There is no report on the detection of HPeVs in Central Europe. Aims: The aim of the retrospective study was to detect and characterize HPeVs using molecular methods in cell cultures with “enterovirus-like” cytophatic effect (CPE) archived between 1990 and 2004, in two virology laboratories, in Hungary. Materials and methods: In Laboratory I, fecal samples from children with symptoms of gastroenteritis under the age of 10 years were cultured as a previous routine diagnostic laboratory protocol for “enterovirus”. Cell cultures indicating CPE were archived between 1990 and 2000. In Laboratory II, 2 fecal samples, a liquor and a nasopharyngeal aspirate were re-tested which contained an “enterovirus-like” virus in cell cultures and were positive by HPeV1 neutralization immunosera between 2000 and 2004. Specimens were tested retrospectively for HPeV by reverse transcription–PCR (RT-PCR) method using 5’UTR conserved primers. Specific primers were designed to determine the HPeV structural region (VP0-VP3-VP1). Results: 9 of the 66 archived samples (9.1%) from Laboratory I and all the 4 samples from Laboratory II were found to be HPeV-positive. 10 samples were identified as HPeV1, 2 were HPeV4 and 1 could not be determined. 3 HPeV1 clusters were identified in Laboratory I according to the isolation date originated from years 1990/1991, 1992/1995 and 1998. HPeV1 was detected in clinical syndromes: gastroenteritis (in a 24-years-old adult), recurrent stomatitis aphtosa (in a 42-years-old adult), encephalitis and ataxia cerebellaris acuta in infants and children in Laboratory II. Conclusions: This is the first detection of HPeVs in Central Europe. Detection and genetic characterization of HPeV in available historical samples infected with previously unidentifiable agents with “enterovirus-like” cytopathogenic effect may help to understand the clinical importance and spectrum of the infections and the genetic diversity and evolution of these viruses. Orv. Hetil., 2011, 152, 1007–1012.

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Acanthamoeba Species in Tap Water, Egypt

International Journal of Pharmaceutical and Clinical Research ◽

10.25258/ijpcr.v9i1.8259 ◽

2017 ◽

Vol 9 (1) ◽

Author(s):

Ahmad Z Al-Herrawy ◽

Mohamed A Marouf ◽

Mahmoud A. Gad

Keyword(s):

Water Samples ◽

Tap Water ◽

Pcr Analysis ◽

Pulmonary Infections ◽

Clinical Syndromes ◽

Acanthamoeba Species ◽

Amebic Encephalitis ◽

Acanthamoeba Culbertsoni ◽

Autumn And Winter

Genus Acanthamoeba causes 3 clinical syndromes amebic keratitis, granulomatous amebic encephalitis and disseminated granulomatous amebic disease (eg, sinus, skin and pulmonary infections). A total of 144 tap water samples were collected from Giza governorate, Egypt. Samples were processed for detection of Acanthamoeba species using non-nutrient agar (NNA) and were incubated at 30oC. The isolates of Acanthamoeba were identified to species level based on the morphologic criteria. Molecular characterization of the Acanthamoeba isolates to genus level was performed by using PCR. The obtained results showed that the highest occurrence percentage of Acanthamoeba species in water samples was observed in summer season (38.9%), then it decreased to be 30.6% in spring and 25% in each of autumn and winter. PCR analysis showed that 100% of 43 Acanthamoeba morphologically positive samples were positive by genus specific primer. In the present study eight species of Acanthamoeba can be morphologically recognized namely Acanthamoeba triangularis, Acanthamoeba echinulata, Acanthamoeba astronyxis, Acanthamoeba comandoni, Acanthamoeba griffini, Acanthamoeba culbertsoni, Acanthamoeba quina and Acanthamoeba lenticulata. In conclusion, the most common Acanthamoeba species in tap water was Acanthamoeba comandoni

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Surgical Case

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v9ispl1.1278 ◽

2018 ◽

Vol 9 (SPL1) ◽

Author(s):

Ali Hameed Al-Badri

Keyword(s):

Diagnostic Delay ◽

Small Population ◽

Negative Appendectomy ◽

Time Cost ◽

Voluntary Cough ◽

Suspected Appendicitis ◽

Sharp Pain ◽

Clinical Syndromes ◽

Negative Appendectomy Rate ◽

Classical Symptom

Appendicitis is a common and urgentsurgical illness with protean manifestations,generous overlap with other clinical syndromes,and significant morbidity,whichincreases with diagnostic delay. No single sign,symptom,or diagnostic test accurately confirms the diagnosis ofappendiceal inflammation in all cases. The surgeon's goals are to evaluate a relatively small population of patients referred for suspected appendicitis and to minimize the negative appendectomy rate without increasing the incidence of perforation. The emergency department clinician must evaluate the larger group of patients who present to the ED with abdominal pain of all etiologies with the goal of approaching 100% sensitivity for the diagnosis in a time-,cost-,and consultation-efficient manner.IN 1886Reginald fitz, pathologist 1st described the clinical condition of A.A.Fewyears laterCharles mcBurney describe the clinical finding ofA.A.55% of patients presented with classical symptom of A.A so complication occurbecauseof atypical presentation which due to variation in app. Position, age of patient & degree of inflammation.Migrating pain 80% sensitive and specific Vomiting 50% Nausea60 -90 %Anorexia 75 % Diarrhea18 % 32 % has similar attach 90 % RLQ tenderness Marklesign 74 %Dunphy's sign (sharp pain in the RLQ elicited by a voluntary cough) may be helpful in making the clinical diagnosis of localized peritonitis. Similarly,RLQ pain in response to percussion of a remote quadrant of the abdomen,or to firm percussion of the patient's heel,suggests peritoneal Inflammation

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PARALISIA BULBAR PROGRESSIVA (PBP): relato de caso

Psicologia e Saúde em Debate ◽

10.22289/2446-922x.v6n2a31 ◽

2020 ◽

Vol 6 (2) ◽

pp. 480-487

Author(s):

Heuler dos Reis Rodrigues ◽

Mariane Fernandes Ribeiro ◽

Carla Cristina Ferreira de Andrade

Keyword(s):

Blood Pressure ◽

Progressive Disease ◽

Rapid Evolution ◽

Peripheral Oxygen Saturation ◽

Course Of Action ◽

Clinical Syndromes ◽

Bulbar Paralysis ◽

Pressure Maximum ◽

Maximum Expiratory Pressure ◽

Object Of Study

Motor neuron disease is a term used in several clinical syndromes, among them Progressive Bulbar Paralysis, a rare degenerative and progressive disease of rapid evolution and loss of early respiratory muscle strength. The characteristics are dysphonia, dysphagia, dysarthria, inability in bronchial hygiene, wheezing breaths and atrophy of the tongue musculature, affecting chewing, the grinding of food is increasingly difficult, affecting chewing, causing a potentially disabling and debilitating disease. This study aimed to describe a clinical case of an individual with a clinical diagnosis of Progressive Bulbar Paralysis in Propaedeutics at the Clinical School of the Faculty of the Alto Paranaíba-MG region. The object of study was a 57-year-old male, who underwent an initial physical therapy evaluation and was collected with maximum physiological pressure: maximum inspiratory pressure, maximum expiratory pressure, Borg CR-10 scale, heart rate (HR), respiratory pressure (RF), systolic blood pressure (SBP), diastolic blood pressure (DBP), peripheral oxygen saturation (SPO2). Then, follow a course of action in accordance with the provisions of the literature on the performance of the disease. The results found in this study are satisfactory, for all eight variables analyzed, with the possibility of highlighting the variable Borg CR-10 as the most satisfactory variable compared.

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Leishmaniasis: clinical syndromes and treatment

QJM ◽

10.1093/qjmed/hct116 ◽

2013 ◽

Vol 107 (1) ◽

pp. 7-14 ◽

Cited By ~ 153

Author(s):

B. S. McGwire ◽

A. R. Satoskar

Keyword(s):

Clinical Syndromes

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Mitochondrial Syndromes Revisited

Journal of Clinical Medicine ◽

10.3390/jcm10061249 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1249

Author(s):

Daniele Orsucci ◽

Elena Caldarazzo Ienco ◽

Andrea Rossi ◽

Gabriele Siciliano ◽

Michelangelo Mancuso

Keyword(s):

Clinical Trials ◽

Genetic Basis ◽

Phenotypic Variability ◽

Mitochondrial Diseases ◽

Genetic Alterations ◽

Mitochondrial Disorders ◽

Single Mutation ◽

Multicenter Studies ◽

Future Studies ◽

Clinical Syndromes

In the last ten years, the knowledge of the genetic basis of mitochondrial diseases has significantly advanced. However, the vast phenotypic variability linked to mitochondrial disorders and the peculiar characteristics of their genetics make mitochondrial disorders a complex group of disorders. Although specific genetic alterations have been associated with some syndromic presentations, the genotype–phenotype relationship in mitochondrial disorders is complex (a single mutation can cause several clinical syndromes, while different genetic alterations can cause similar phenotypes). This review will revisit the most common syndromic pictures of mitochondrial disorders, from a clinical rather than a molecular perspective. We believe that the new phenotype definitions implemented by recent large multicenter studies, and revised here, may contribute to a more homogeneous patient categorization, which will be useful in future studies on natural history and clinical trials.

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Pathophysiology and therapy for haemoglobinopathies; Part II: thalassaemias

Expert Reviews in Molecular Medicine ◽

10.1017/s1462399406010805 ◽

2006 ◽

Vol 8 (10) ◽

pp. 1-26 ◽

Cited By ~ 13

Author(s):

Fabrizia Urbinati ◽

Catherine Madigan ◽

Punam Malik

Keyword(s):

Single Gene ◽

Globin Gene ◽

Marrow Transplant ◽

World Population ◽

Symptomatic Therapy ◽

Globin Genes ◽

Cell Disease ◽

Critical Function ◽

Single Gene Disorders ◽

Clinical Syndromes

Thalassaemias result from mutations of the globin genes that cause reduced or absent haemoglobin production and thus interfere with the critical function of oxygen delivery. They represent the most common single-gene disorders, with 4.83% of the world population carrying globin gene variants. Reduced or absent α-globin (α-thalassaemia) or β-globin (β-thalassaemia) leads to anaemia and multifaceted clinical syndromes. In this second of two reviews on the pathophysiology of haemoglobinopathies, we describe the clinical features, pathophysiology and molecular basis of α- and β-thalassaemias. We then discuss current targeted therapies, including the new oral iron chelators, which, along with chronic transfusions, constitute the mainstay of symptomatic therapy for the majority of patients. Finally, we describe potentially curative therapies, such as bone marrow transplant, and discuss some of the outstanding research studies and questions, including the upcoming field of gene therapy for β-thalassaemia. An accompanying article on haemoglobinopathies (Part I) focuses on sickle cell disease.

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