Mammary gland differentiation in female rats after prenatal exposure to 3,3′,4,4′,5-pentachlorobiphenyl

Toxicology ◽  
2002 ◽  
Vol 177 (2-3) ◽  
pp. 197-205 ◽  
Author(s):  
Tomoko Muto ◽  
Shin Wakui ◽  
Noboru Imano ◽  
Kenji Nakaaki ◽  
Hiroyuki Takahashi ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Prenatal Exposure ◽  
Female Rats ◽  
Mammary Gland Differentiation

The effect of bromocriptine on mammary-gland ultrastructure of hyperprolactinemic rats

1984 ◽  
Vol 42 ◽  
pp. 204-205
Author(s):  
I.C. Murray
Keyword(s):  
Mammary Gland ◽  
Dopamine Agonist ◽  
Alveolar Epithelium ◽  
Mammary Glands ◽  
Female Rats ◽  
Control Group ◽  
Cell Hyperplasia ◽  
Once Daily ◽  
Long Evans

In women, hyperprolactinemia is often due to a prolactin (PRL)-secreting adenoma or PRL cell hyperplasia. RRL excess stimulates the mammary glands and causes proliferation of the alveolar epithelium. Bromocriptine, a dopamine agonist, inhibits PRL secretion and is given to women to treat nonpuerperal galactorrhea. Old female rats have been reported to have PRL cell hyperplasia or adenoma leading to PRL hypersecretion and breast stimulation. Herein, we describe the effect of bromocriptine and consequently the reduction in serum PRL levels on the ultrastructure of rat mammary glands.Female Long-Evans rats, 23 months of age, were divided into control and bromocriptine-treated groups. The control animals were injected subcutaneously once daily with a 10% ethanol vehicle and were later divided into a normoprolactinemic control group with serum PRL levels under 30 ng/ml and a hyperprolactinemic control group with serum PRL levels above 30 ng/ml.

Ultrastructural Changes in the Mammary Epithelial Cell Population During Neoplastic Development Induced by A Chemical Carcinogen.

1976 ◽  
Vol 34 ◽  
pp. 250-251 ◽  
Author(s):  
J. Russo ◽  
W. Isenberg ◽  
M. Ireland ◽  
I.H. Russo
Keyword(s):  
Mammary Gland ◽  
Cell Population ◽  
Virgin Female ◽  
Histological Change ◽  
Mammary Epithelial ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Chemical Carcinogen ◽  
Sprague Dawley

The induction of rat mammary carcinoma by the chemical carcinogen DMBA is used as a model for the study of the human disease (1). We previously described the histochemical changes that occur in the mammary gland of DMBA treated animals before the earliest manifested histological change, the intraductal proliferation (IDP), was observed (2). In the present work, we demonstrate that a change in the stable cell population found in the resting mammary gland occurs after carcinogen administration.Fifty-five day old Sprague-Dawley virgin female rats were inoculated intragastrically with 20mg of 7,12-dimethylbenz(a)anthracene (DMBA) in 1ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from control and inoculated rats were removed weekly from the time of inoculation until 60 days post-inoculation. For electron microscopy, the glands were immersed in Karnovsky's fixative, post-fixed in 1% OsO4, dehydrated, and embedded in an Epon-Araldite mixture. Thick (lμ) sections were stained with 1% toluidine blue and were used for selecting areas for ultrastructural study.

scholarly journals Inhibition of Mammary Gland Differentiation in Vitro by 5-Bromo-2'-deoxyuridine

1971 ◽  
Vol 246 (6) ◽  
pp. 1814-1819
Author(s):  
Roger W. Turkington ◽  
Gopal C. Majumder ◽  
Marie Riddle
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Differentiation

Mammary gland differentiation by early life exposure to enantiomers of the soy isoflavone metabolite equol

2010 ◽  
Vol 48 (11) ◽  
pp. 3042-3050 ◽  
Author(s):  
N.M. Brown ◽  
C.A. Belles ◽  
S.L. Lindley ◽  
L. Zimmer-Nechemias ◽  
D.P. Witte ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Early Life ◽  
Soy Isoflavone ◽  
Early Life Exposure ◽  
Mammary Gland Differentiation

scholarly journals Fennel (Foeniculum vulgare) leaf infusion effect on mammary gland activity and kidney function of lactating rats

2019 ◽  
Vol 11 (1) ◽  
pp. 101-105
Author(s):  
NAJDA RIFQIYATI ◽  
ANA WAHYUNI
Keyword(s):  
Uric Acid ◽  
Mammary Gland ◽  
Side Effects ◽  
Kidney Function ◽  
Uric Acid Level ◽  
Acid Level ◽  
Mammary Glands ◽  
Female Rats ◽  
Foeniculum Vulgare ◽  
Treatment Groups

Abstract. Rifqiyati N, Wahyuni A. 2019. Fennel (Foeniculum vulgare) leaf  infusion effect on mammary gland activity and kidney function of lactating rats. Nusantara Bioscience 11: 101-105. Fennel (Foeniculum vulgare Mill) leaf, traditionally, is believed to have a potential in increasing and smoothing breast milk production. This study aimed to determine the effect of fennel leaf infusion on milk production and to know the side effects of its use. The material used in the research was infusion of fennel leaves (Foeniculum vulgare Mill) collected from Kopeng, Central Java. The research utilized 12 female rats each with 5 newborns off springs. The experiment was designed in Completed Random Design (CRD) with 4 treatments and 3 replications. Histological preparation of mammary glands was set using paraffin method with HE staining. Kidney function was observed through uric acid level in the blood. The results showed that the diameter of lactiferous ducts and of its lumen diameter were significantly influenced by 15 days fennel leaf infusion treatment. The largest lactiferous duct diameter observed was on P3 treatment group (452.97 ± 75.033 µm) and the smallest was observed in control groups (273.17 ± 38.746 µm). The numbers of active alveoli observed in treatment groups, i.e., in P1 (20 g/300  mL), P2 (40 g/300  mL), and P3 (60 g/300  mL), increased than inactive alveoli. The blood uric acid level observed was 4.0-4.6 mg/dl. The results suggested that the infusion of fennel leaf with a treatment dose of 60 g infusion in 300  mL distilled water administered for 15 days can significantly increase the diameter of lactiferous lumen of female rat mammary glands, and increase the diameter of the alveoli and the number of active alveolar mammary glands. Histological picture of mammary gland also showed that the female rats treated with dose of 60g infusion per 300  mL aquadest increased milk secretion and than the other treatment groups. The treatment also showed no significant side effects.  

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