scholarly journals Fennel (Foeniculum vulgare) leaf infusion effect on mammary gland activity and kidney function of lactating rats

2019 ◽  
Vol 11 (1) ◽  
pp. 101-105
Author(s):  
NAJDA RIFQIYATI ◽  
ANA WAHYUNI
Keyword(s):  
Uric Acid ◽  
Mammary Gland ◽  
Side Effects ◽  
Kidney Function ◽  
Uric Acid Level ◽  
Acid Level ◽  
Mammary Glands ◽  
Female Rats ◽  
Foeniculum Vulgare ◽  
Treatment Groups

Abstract. Rifqiyati N, Wahyuni A. 2019. Fennel (Foeniculum vulgare) leaf  infusion effect on mammary gland activity and kidney function of lactating rats. Nusantara Bioscience 11: 101-105. Fennel (Foeniculum vulgare Mill) leaf, traditionally, is believed to have a potential in increasing and smoothing breast milk production. This study aimed to determine the effect of fennel leaf infusion on milk production and to know the side effects of its use. The material used in the research was infusion of fennel leaves (Foeniculum vulgare Mill) collected from Kopeng, Central Java. The research utilized 12 female rats each with 5 newborns off springs. The experiment was designed in Completed Random Design (CRD) with 4 treatments and 3 replications. Histological preparation of mammary glands was set using paraffin method with HE staining. Kidney function was observed through uric acid level in the blood. The results showed that the diameter of lactiferous ducts and of its lumen diameter were significantly influenced by 15 days fennel leaf infusion treatment. The largest lactiferous duct diameter observed was on P3 treatment group (452.97 ± 75.033 µm) and the smallest was observed in control groups (273.17 ± 38.746 µm). The numbers of active alveoli observed in treatment groups, i.e., in P1 (20 g/300  mL), P2 (40 g/300  mL), and P3 (60 g/300  mL), increased than inactive alveoli. The blood uric acid level observed was 4.0-4.6 mg/dl. The results suggested that the infusion of fennel leaf with a treatment dose of 60 g infusion in 300  mL distilled water administered for 15 days can significantly increase the diameter of lactiferous lumen of female rat mammary glands, and increase the diameter of the alveoli and the number of active alveolar mammary glands. Histological picture of mammary gland also showed that the female rats treated with dose of 60g infusion per 300  mL aquadest increased milk secretion and than the other treatment groups. The treatment also showed no significant side effects.  

scholarly journals Uric Acid Level Has a U-Shaped Association with Loss of Kidney Function in Healthy People: A Prospective Cohort Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0118031 ◽  
Author(s):  
Eiichiro Kanda ◽  
Toshitaka Muneyuki ◽  
Yoshihiko Kanno ◽  
Kaname Suwa ◽  
Kei Nakajima
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Kidney Function ◽  
Prospective Cohort Study ◽  
Uric Acid Level ◽  
Prospective Cohort ◽  
Acid Level ◽  
Healthy People

scholarly journals Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Zhenqiang You ◽  
Junying Sun ◽  
Feng Xie ◽  
Zhiqin Chen ◽  
Sheng Zhang ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Oxidative Dna Damage ◽  
Mammary Glands ◽  
Estradiol Benzoate ◽  
Female Rats ◽  
Control Group ◽  
High Dose ◽  
Protective Effects ◽  
Treatment Groups ◽  
Group A

Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs). Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration. FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum. Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands. Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG). These indices reverted to normal levels upon oral administration of a high dose of FPEs. Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.

scholarly journals Penatalaksanaan Hiperurisemia Pada Penyakit Ginjal Kronik (CKD)

2021 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Haidar Alatas
Keyword(s):  
Weight Loss ◽  
Uric Acid ◽  
Side Effects ◽  
Uric Acid Level ◽  
Alternative Treatment ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Meat Consumption ◽  
Not Given ◽  
High Fructose

Management of hyperuricemia in CKD includes non pharmacology and pharmacology. Non-pharmacological with lifestyle change interventions such as exercise, weight loss, low purine meat consumption, avoid high fructose, reduce alcohol and herbs. The treatment of asymptomatic hyperuricemia in CKD is still controversial. In Japan and Korea given uric acid-lowering drugs when the serum uric acid level (SUA)> 8 mg / dl but in America and Europe are not given drugs for fear of side effects. Soursop fruit consumption can be an alternative treatment for hyperuricemia in CKD both asymptomatic and symptomatic. The recommended drugs for hyperuricemia in CKD are allopurinol and febuxostat. Allopurinol is excreted through the kidneys so it is necessary to adjust the dose in CKD, starting from 50-100 mg / day, increasing it to 200-300 mg / day every 2-5 weeks until SUA <6 mg / dl. The dose may be> 300 mg / day if the patient is notified and the monitor may be toxic. In America, Europe and Japan recommend febuxostat only for the treatment of hyperuricemia.

scholarly journals Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hye Jin Joo ◽  
Gyu Ri Kim ◽  
Dong-Woo Choi ◽  
Jae Hong Joo ◽  
Eun-Cheol Park
Keyword(s):  
Uric Acid ◽  
Kidney Disease ◽  
Confidence Intervals ◽  
Kidney Function ◽  
National Health ◽  
Uric Acid Level ◽  
Acid Level ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Reduced Kidney Function

AbstractKidney disease is expected to become the fifth leading cause of premature death globally by 2040. Uric acid level is a risk factor for kidney disease. The current study aims to investigate the association between uric acid levels and kidney function in the Korean population. The data of 11,042 participants of the 2016–2017 Korea National Health and Nutrition Examination Survey were analysed. The estimated glomerular filtration rate was calculated using the modification of diet in renal disease formula for Koreans. For each sex, uric acid levels were divided into five subsequent categories of increasing levels (Q1, Q2, Q3, Q4, and hyperuricemia). The association between uric acid level and kidney function was investigated using multiple logistic regression. The results showed that the higher the uric acid levels, the greater the odds of reduced kidney function in both sexes. In men, the adjusted odds ratios (95% confidence intervals) for reduced eGFR comparing the hyperuricemia group to the lowest serum uric acid quartile was 5.55 (3.27–9.44), and in women, the odds ratios (95% confidence intervals) was 7.52 (4.39–12.87). Normal weight or underweight in men and overweight in women, as well as diabetes mellitus, hypertension, and physical inactivity were highly associated with reduced kidney function. Our study revealed a dose–response relationship between uric acid levels and kidney function. Therefore, high uric acid level should be considered as a factor that is potentially related to kidney dysfunction in the Korean population.

scholarly journals Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study

2018 ◽  
Vol 20 (4) ◽  
pp. 775-783 ◽  
Author(s):  
Stanford E. Mwasongwe ◽  
Tibor Fülöp ◽  
Ronit Katz ◽  
Solomon K. Musani ◽  
Mario Sims ◽  
...  
Keyword(s):  
Uric Acid ◽  
Kidney Disease ◽  
Kidney Function ◽  
Uric Acid Level ◽  
Acid Level ◽  
Jackson Heart Study ◽  
Heart Study ◽  
Kidney Function Decline

scholarly journals PENGARUH PEMBERIAN AIR REBUSAN DAUN SALAM (SYZYGIUM POLYANTHUM) TERHADAP PENURUNAN KADAR ASAM URAT

2018 ◽  
Vol 12 (3) ◽  
pp. 222 ◽  
Author(s):  
Aidaa - Andriani
Keyword(s):  
Uric Acid ◽  
Side Effects ◽  
Uric Acid Level ◽  
Acid Level ◽  
Sampling Method ◽  
The Body ◽  
P Value ◽  
Work Area ◽  
Before And After ◽  
Area Health

<p><em>Gout</em><em> is a disease because of abnormalities purine metabolism (hyperuricemia). </em><em>In gout treatment there are many different ways to lower uric acid levels one by utilizing existing natural vegetation. Plants or plants that can be used is the bay leaf (Syzygium polyanthum)</em><em>. Bay leaf contains flavonoids that can lower uric acid levels. This study intends to find out The Effect Of Water Decoction Bay Leaf </em><em>(Syzygium polyanthum)<strong> </strong></em><em>The Decrease</em><em> Uric Acid Levels In The Work Area Health Center Paninggahan Solok 2013.This research is the method of approach Preeksperimental pretest - posttest, using total sampling method with a sample size of 10 people.</em> <em>The data was collected</em><em> directly to the respondents by interview, observation and measurement sheet uric acid levels and blood sugar.The research found that there are differences in uric acid levels before and after giving the water decoction bay leaf. </em><em>Based on the result test T there are differences in uric acid levels before and after </em><em>giving the water decoction of bay leaf. Where the average uric acid levels before was 7.16 mg / dl, and after the uric acid level was 5.76 mg / dl. Then obtained p value = 0.000. Based on the results of this study concluded that consuming the water decoction of bay leaf can lower uric acid levels, because </em><em>leaves contains flavanoid </em><em>. For that</em><em> gout sufferers is recommended to consume the water decoction of bay leaf  to control uric acid levels in the body.</em> <em>it</em><em> is required to research more about the side effects and benefits of bay leaf.</em></p><p><em>Penyakit asam urat merupakan suatu penyakit karena kelainan metabolisme purin (hiperurisemia). </em><em>U</em><em>ntuk menurunkan kadar asam urat salah satunya dengan memanfaatkan tumbuhan alami yang ada. Tumbuhan atau tanaman yang dapat digunakan adalah daun salam. Daun salam memiliki kandungan flavonoid yang mampu menurunkan kadar asam urat. Penelitian ini bertujuan untuk mengetahui adanya Pengaruh Pemberian Air Rebusan Daun Salam Terhadap Penurunan Kadar Asam Urat .Jenis penelitian ini adalah Pre eksperimental dengan metode pendekatan Pretest – Posttest. dengan menggunakan metode total sampling dengan jumlah sampel sebanyak 10 orang. Pengumpulan data dilakukan secara langsung terhadap responden dengan wawancara, lembar observasi dan pengukuran kadar asam urat dan gula darah. Hasil penelitian ditemukan bahwa terdapat perbedaan kadar asam urat sebelum dan sesudah pemberian air rebusan daun salam. Berdasarkan hasil Uji T terdapat perbedaan kadar asam urat sebelum dan sesudah pemberian air rebusan daun salam. Dimana rata- rata kadar asam urat sebelum adalah 7,16 mg/dl, dan kadar asam urat sesudah adalah 5,76 mg/dl. Maka didapatkan nilai p= 0,000.Berdasarkan hasil penelitian dapat disimpulkan bahwa mengkonsumsi air rebusan daun salam dapat menurunkan kadar asam urat, karena </em><em>flavanoid yang terkandung dalam daun salam</em><em>. Untuk itu dibutuhkan penelitian lebih lanjut tentang efek samping dan manfaat lain dari daun salam. </em></p>

The effect of bromocriptine on mammary-gland ultrastructure of hyperprolactinemic rats

1984 ◽  
Vol 42 ◽  
pp. 204-205
Author(s):  
I.C. Murray
Keyword(s):  
Mammary Gland ◽  
Dopamine Agonist ◽  
Alveolar Epithelium ◽  
Mammary Glands ◽  
Female Rats ◽  
Control Group ◽  
Cell Hyperplasia ◽  
Once Daily ◽  
Long Evans

In women, hyperprolactinemia is often due to a prolactin (PRL)-secreting adenoma or PRL cell hyperplasia. RRL excess stimulates the mammary glands and causes proliferation of the alveolar epithelium. Bromocriptine, a dopamine agonist, inhibits PRL secretion and is given to women to treat nonpuerperal galactorrhea. Old female rats have been reported to have PRL cell hyperplasia or adenoma leading to PRL hypersecretion and breast stimulation. Herein, we describe the effect of bromocriptine and consequently the reduction in serum PRL levels on the ultrastructure of rat mammary glands.Female Long-Evans rats, 23 months of age, were divided into control and bromocriptine-treated groups. The control animals were injected subcutaneously once daily with a 10% ethanol vehicle and were later divided into a normoprolactinemic control group with serum PRL levels under 30 ng/ml and a hyperprolactinemic control group with serum PRL levels above 30 ng/ml.

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

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