The juvenile Göttingen Minipig: role of organ development in view of food and drug safety in neonates, infants and toddlers

2021 ◽  
Vol 350 ◽  
pp. S22
Author(s):  
S.J. Van Cruchten
Keyword(s):  
Drug Safety ◽  
Organ Development ◽  
Infants And Toddlers ◽  
Göttingen Minipig

scholarly journals Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila

2021 ◽  
Vol 12 (9) ◽  
Author(s):  
Dae-Wook Yang ◽  
Jung-Wan Mok ◽  
Stephanie B. Telerman ◽  
Robert Amson ◽  
Adam Telerman ◽  
...  
Keyword(s):  
Cell Survival ◽  
Topoisomerase Ii ◽  
Wing Disc ◽  
Organ Development ◽  
Translationally Controlled Tumor Protein ◽  
Protein Levels ◽  
Eye Disc ◽  
Mutual Regulation

AbstractRegulation of cell survival is critical for organ development. Translationally controlled tumor protein (TCTP) is a conserved protein family implicated in the control of cell survival during normal development and tumorigenesis. Previously, we have identified a human Topoisomerase II (TOP2) as a TCTP partner, but its role in vivo has been unknown. To determine the significance of this interaction, we examined their roles in developing Drosophila organs. Top2 RNAi in the wing disc leads to tissue reduction and caspase activation, indicating the essential role of Top2 for cell survival. Top2 RNAi in the eye disc also causes loss of eye and head tissues. Tctp RNAi enhances the phenotypes of Top2 RNAi. The depletion of Tctp reduces Top2 levels in the wing disc and vice versa. Wing size is reduced by Top2 overexpression, implying that proper regulation of Top2 level is important for normal organ development. The wing phenotype of Tctp RNAi is partially suppressed by Top2 overexpression. This study suggests that mutual regulation of Tctp and Top2 protein levels is critical for cell survival during organ development.

Personal and environmental factors contributing to parenting stress among employed and nonemployed women

1993 ◽  
Vol 7 (2) ◽  
pp. 107-118 ◽  
Author(s):  
Deborah Kirby Forgays ◽  
Donald G. Forgays
Keyword(s):  
Environmental Factors ◽  
Parenting Stress ◽  
Employment Status ◽  
Somatic Complaints ◽  
Infants And Toddlers ◽  
Household Chores ◽  
The Past ◽  
Self Confidence ◽  
Additional Role

Over the past 20 years, significantly more women have returned to the workforce after the birth of their child. Despite gains made by the second women's movement and attendant socio‐political changes, women continue to bear the major parenting responsibilities in addition to household chores. Does this additional role of workforce member result in a more highly stressed mother? This study recruited 120 mothers of infants and toddlers from a range of occupations who provided information on their adjustment to parenting as well as individual difference factors such as maternal self‐confidence, somatic complaints, and Type A behaviour. The results suggest that the level of parenting stress is not related to employment status alone. However, the factors contributing to reported parenting stress do vary by employment status. These results highlight the need to examine the interaction of personal and environmental dimensions when studying this complex area.

Are We Maximizing the Role of Caregivers’ Support Networks in Early Intervention?

2019 ◽  
Vol 42 (3) ◽  
pp. 203-223
Author(s):  
Nicole Megan Edwards
Keyword(s):  
Early Intervention ◽  
Ecological Systems ◽  
Strategy Use ◽  
Support Networks ◽  
Natural Environments ◽  
Infants And Toddlers ◽  
Part C ◽  
Home Based ◽  
Part C Early Intervention

Part C Early Intervention is intended to build capacity among caregivers of infants and toddlers with special needs to use tailored strategies in natural environments. Satisfaction and perceived strategy use, however, remain unclear. In a Northeastern home-based program, caregivers ( n = 195; 33% response) and providers ( n = 66; 33% response) answered questions on strategy use, whether others are asked to use strategies, and perceived compliance. A subset of providers participated in a focus group. Most providers were “somewhat confident” caregivers use recommended strategies. Half of providers consistently encouraged caregivers to ask others to use strategies, with this linked to familiarity with ecological systems theory. Despite 86.2% of caregivers asking one or more person to use strategies, there was little confidence in compliance. Findings and implications are discussed, including revisiting coaching practices, exploring variability in support networks, and promoting strategy use across key partners.

Quality not quantity: Key success factors from the first decade of safety reports from the Research on Adverse Drug Events and Reports project (RADAR)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6559-6559
Author(s):  
C. Bennett ◽  
B. J. Edwards ◽  
C. C. Tigue ◽  
D. W. Raisch ◽  
D. M. Courtney ◽  
...  
Keyword(s):  
Drug Safety ◽  
Success Factors ◽  
Adverse Drug Events ◽  
Case Reports ◽  
Signal Generation ◽  
Drug Reactions ◽  
High Quality ◽  
Key Success Factors ◽  
Safety Signals

6559 Background: RADAR is the only independent academic pharmacovigilance organization funded exclusively by peer-reviewed grants. We describe the role of high quality case reports in the detection of drug safety signals. Methods: RADAR has identified 11 cancer-related adverse drug reactions (ADRs). Initial reports for small numbers of cases were obtained from our own institution, NU, (4 ADRs) or from referral centers (7 ADRs). Clinicians at these centers voluntarily provided brief case reports to RADAR, who submitted detailed case reports to the FDA/manufacturer. Clinicians were promised that patient/provider data would be kept confidential and that these data would be submitted as peer-reviewed manuscripts. Results: See Table. Conclusions: RADAR was successful at signal generation and amplification because it focused on quality, not quantity of case reports. Pharmacovigilance efforts that allow clinicians to complete brief forms, maintain confidentiality of patient and provider, and result in submission of collaborative manuscripts may improve early detection of drug safety signals initiatives in oncology. [Table: see text] No significant financial relationships to disclose.

Drug Safety: The Role of Regulatory Authorities

2002 ◽  
Vol 29 ◽  
pp. 47-49
Author(s):  
Hans-Joachim Meencke
Keyword(s):  
Drug Safety ◽  
Regulatory Authorities

scholarly journals Infant Strangulation from an Amber Teething Necklace

CJEM ◽  
2016 ◽  
Vol 19 (5) ◽  
pp. 400-403 ◽  
Author(s):  
Catherine Cox ◽  
Neil Petrie ◽  
Katrina F. Hurley
Keyword(s):  
Time Use ◽  
Professional Organizations ◽  
Infants And Toddlers ◽  
Aspiration Risk ◽  
Health Canada ◽  
First Time

AbstractAmber teething necklaces supposedly provide analgesia for teething infants. Their use is becoming more widespread, despite lack of peer-reviewed evidence and warnings from Health Canada that they pose a strangulation and aspiration risk. To date, there have been no published reports of strangulation secondary to amber teething necklaces. In this report we present a case of non-fatal infant strangulation from the first time use of an amber teething necklace. We will also discuss the role of physicians as advocates in reporting similar cases and educating families. Finally, we will comment on the responsibility of all professionals and professional organizations that work with infants and toddlers to advocate for children by raising concerns and counselling parents.

scholarly journals Role of Pharmacy in the Promotion of Drug Safety in Pharmacotherapy

2018 ◽  
Vol 138 (2) ◽  
pp. 149-150
Author(s):  
Mitsutoshi Satoh
Keyword(s):  
Drug Safety
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