Vulnerability to noise-induced hearing loss in ‘middle-aged’ and young adult mice: a dose–response approach in CBA, C57BL, and BALB inbred strains

2000 ◽  
Vol 149 (1-2) ◽  
pp. 239-247 ◽  
Author(s):  
Kevin K Ohlemiller ◽  
James S Wright ◽  
Arnold F Heidbreder
Keyword(s):  
Hearing Loss ◽  
Young Adult ◽  
Dose Response ◽  
Inbred Strains ◽  
Noise Induced Hearing Loss ◽  
Middle Aged ◽  
Adult Mice

Hörgesundheit: lärminduzierter Hörverlust droht bei häufiger Lärmexposition

2019 ◽  
Vol 98 (03) ◽  
pp. 144-146
Author(s):  
Helmut Schaaf
Keyword(s):  
Hearing Loss ◽  
Young Adult ◽  
Noise Induced Hearing Loss ◽  
Early Indication

Hussain T et al. Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices. Ann Otol Rhinol Laryngol 2018; 127: 703–709 Tragbare Medienabspielgeräte haben eine enorme Anziehungskraft entwickelt, nicht zuletzt durch die Einführung des iPod von Apple im Jahr 2001. Die Integration solcher Abspielgeräte in Mobiltelefone hat ihre Verwendung insbesondere bei jungen Erwachsenen weiter erhöht, was Anlass zur Besorgnis hinsichtlich schädlicher Auswirkungen auf das Gehör gibt.

scholarly journals Association between Smoking and Noise-Induced Hearing Loss: A Meta-Analysis of Observational Studies

2020 ◽  
Vol 17 (4) ◽  
pp. 1201
Author(s):  
Xiaowen Li ◽  
Xing Rong ◽  
Zhi Wang ◽  
Aihua Lin
Keyword(s):  
Hearing Loss ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Noise Induced Hearing Loss ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Slow Decline ◽  
Former Smokers

The purpose of this study was to synthesize the results of previously published observational studies through meta-analysis to clarify the association between smoking and noise-induced hearing loss (NIHL). We searched several databases as of October 2019. Based on the results of heterogeneity analysis (Q statistic and I2 statistic), a fixed effect model (for no heterogeneity; Q test P > 0.1 and I2 ≤ 50%) or a random effects model (for heterogeneity) was used to calculate the pooled odds ratios (ORs). We explored the potential dose-response relationship between smoking and NIHL as well. In total, 27 studies involving 30,465 participants were included. Compared with non-smokers, the pooled OR of current smokers was 2.05 (95% Confidence interval (CI): 1.71–2.46), and of former smokers was 1.11 (95% CI: 1.05–1.18). We found a curve linear association between an increasing number of pack-years (packages/day × smoking years) and risk of NIHL. The dose-response meta-analysis suggested that when the number of pack-years was less than fifteen, the risk of NIHL was increasing, and the highest combined OR was 5.25 (95% CI: 2.30–11.96) for pack-years of fifteen. After fifteen pack-years, the pooled OR had a slow decline. Our study indicated that smoking is a risk factor for NIHL. Current smokers have a higher risk than former smokers, and there is a positive dose-response relationship between smoking and NIHL.

Abstract 123: Age-Related Diminishment of the Subventricular Zone Cytogenic Response and Its Contributions to Motor Recovery After Cortical Infarcts

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Michael R Williamson ◽  
Stephanie Le ◽  
Ronald L Franzen ◽  
Michael R Drew ◽  
Theresa A Jones
Keyword(s):  
Young Adult ◽  
Subventricular Zone ◽  
Motor Recovery ◽  
Lineage Tracing ◽  
Stem Cell Markers ◽  
Middle Aged ◽  
Reaching Task ◽  
Aged Mice ◽  
Adult Mice ◽  
Age Related

Stroke increases proliferation within the subventricular zone (SVZ) cytogenic niche and causes subsequent migration of newborn cells towards the site of injury. We investigated the functional consequences of age-related blunting of the SVZ cytogenic response to ischemia. We found that there was a marked reduction in proliferation and neural stem cell markers within the SVZ of middle aged (aged 12-16 months) versus young adult (aged 3-5 months) mice in the intact brain and after photothrombotic infarcts in motor cortex. Using an inducible, heritable lineage tracing system (Nestin-CreER T2 :: Ai14 mice) to quantify SVZ-derived neural precursor cells (NPCs) that migrated towards the infarct, we found that there was a considerable age-related reduction in the number of NPCs in peri-infarct cortex. These findings indicate a marked diminishment of SVZ NPC proliferation and migration after focal ischemia by middle age. Next, we assessed the contributions of the SVZ cytogenic response to recovery of skilled motor function. We used glial fibrillary acidic protein-thymidine kinase mice to conditionally ablate NPCs with ganciclovir administration. In young adult mice, NPC ablation significantly impaired recovery of motor performance on the single seed reaching task after motor cortical infarcts. By contrast, NPC ablation did not affect motor recovery in middle aged mice. Importantly, the magnitude of recovery was less in middle aged mice—regardless of NPC ablation—than in control young adult mice. Middle aged mice recovered similarly to young adult mice lacking NPCs. These results indicate that SVZ cytogenesis contributes to functional improvements after cortical infarcts and that the diminishment of the cytogenic response with age may be implicated in age-related worsening of outcome after stroke. Restoration of SVZ cytogenesis in aged animals might improve behavioral recovery.

Effect of epithelial stem cell transplantation on noise-induced hearing loss in adult mice

2011 ◽  
Vol 41 (2) ◽  
pp. 552-559 ◽  
Author(s):  
Jeremy M. Sullivan ◽  
Mauricio A. Cohen ◽  
Sonali R. Pandit ◽  
Raguwinder S. Sahota ◽  
Alexander A. Borecki ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Noise Induced Hearing Loss ◽  
Epithelial Stem Cell ◽  
Adult Mice

scholarly journals Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging

2020 ◽  
Author(s):  
Maria Gerasimenko ◽  
Olga Lopatina ◽  
Anna A. Shabalova ◽  
Stanislav M. Cherepanov ◽  
Alla B. Salmina ◽  
...  
Keyword(s):  
Body Weight ◽  
Young Adult ◽  
Social Behavior ◽  
Body Weight Gain ◽  
Male Mice ◽  
Aging Effects ◽  
Middle Aged ◽  
Nad Metabolism ◽  
Cd38 Expression ◽  
Adult Mice

Abstract The ability of CD38 and CD157 to consume nicotinamide adenine dinucleotide (NAD) has received much attention because aging-induced elevation of CD38 expression plays a role in the senescence-related decline in NAD levels. Therefore, it is of interest to examine and compare the effects of age-associated changes on the general health and brain function impairment of Cd157 and Cd38 knockout (CD157 KO and CD38 KO) mice. Body weight and behaviors were measured in 8-week-old (young adult) or 12-month-old (middle-aged) male mice of both KO strains. The locomotor activity, anxiety-like behavior, and social behavior of mice were measured in open field, and three-chamber tests. Middle-aged CD157 KO male mice gained more body weight than young adult mice, while little or no body weight gain was observed in middle-aged CD38 KO mice. Middle-aged CD157 KO mice displayed increased anxiety-like behavior and decreased sociability and interaction compared with young adult KO mice. Middle-aged CD38 KO mice showed less anxiety and hyperactivity than CD157 KO mice, similar to young adult CD38 KO mice. The results reveal marked age-dependent changes in male CD157 KO mice but not in male CD38 KO mice. We discuss the distinct differences in aging effects from the perspective of inhibition of NAD metabolism in CD157 and CD38 KO mice, which may contribute to differential behavioral changes during aging.

Coping strategies used by middle-aged males with noise-induced hearing loss, with and without tinnitus

1992 ◽  
Vol 7 (4) ◽  
pp. 273-288 ◽  
Author(s):  
Lillemor R.-M. Hallberg ◽  
Soly I. Erlandsson ◽  
Sven G. Carlsson
Keyword(s):  
Hearing Loss ◽  
Coping Strategies ◽  
Noise Induced Hearing Loss ◽  
Middle Aged

scholarly journals Healthy Brain Aging Modifies Microglial Calcium Signaling In Vivo

2019 ◽  
Vol 20 (3) ◽  
pp. 589 ◽  
Author(s):  
Maria Olmedillas del Moral ◽  
Nithi Asavapanumas ◽  
Néstor Uzcátegui ◽  
Olga Garaschuk
Keyword(s):  
Young Adult ◽  
Brain Aging ◽  
Critical Role ◽  
Low Grade ◽  
Middle Aged ◽  
Senescent Phenotype ◽  
Adult Mice ◽  
Age Related ◽  
Old Mice

Brain aging is characterized by a chronic, low-grade inflammatory state, promoting deficits in cognition and the development of age-related neurodegenerative diseases. Malfunction of microglia, the brain-resident immune cells, was suggested to play a critical role in neuroinflammation, but the mechanisms underlying this malfunctional phenotype remain unclear. Specifically, the age-related changes in microglial Ca2+ signaling, known to be linked to its executive functions, are not well understood. Here, using in vivo two-photon imaging, we characterize intracellular Ca2+ signaling and process extension of cortical microglia in young adult (2–4-month-old), middle-aged (9–11-month-old), and old (18–21-month-old) mice. Our data revealed a complex and nonlinear dependency of the properties of intracellular Ca2+ signals on an animal’s age. While the fraction of cells displaying spontaneous Ca2+ transients progressively increased with age, the frequencies and durations of the spontaneous Ca2+ transients followed a bell-shaped relationship, with the most frequent and largest Ca2+ transients seen in middle-aged mice. Moreover, in old mice microglial processes extending toward an ATP source moved faster but in a more disorganized manner, compared to young adult mice. Altogether, these findings identify two distinct phenotypes of aging microglia: a reactive phenotype, abundantly present in middle-aged animals, and a dysfunctional/senescent phenotype ubiquitous in old mice.

Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices

2018 ◽  
Vol 127 (10) ◽  
pp. 703-709 ◽  
Author(s):  
Timon Hussain ◽  
Carol Chou ◽  
Erika Zettner ◽  
Peter Torre ◽  
Stefan Hans ◽  
...  
Keyword(s):  
Young Adults ◽  
Hearing Loss ◽  
Young Adult ◽  
Occupational Safety ◽  
Objective Assessment ◽  
Pure Tone Audiometry ◽  
Subjective Assessment ◽  
Noise Induced Hearing Loss ◽  
Hearing Ability ◽  
Hearing Thresholds

Objectives: The recent integration of portable music players into cell phones has further increased the use of personal listening devices (PLD) among young adults, raising concerns about potentially hazardous effects on hearing. Methods: Assessment of young adults’ hearing ability and listening preferences by subjective and objective measurement. Young adult users of PLDs (n = 50; 30 females, 20 males; mean age = 24.1 ± 4.2 years; average PLD use = 6.1 ± 2.1 years) were included. Subjective assessment of listening preferences was performed via a questionnaire as well as objective assessment of preferred volume levels in different background noise environments and hearing tests. Results: Preferred volume levels were significantly correlated with hearing thresholds. Most participants exhibited safe listening behavior according to National Institute for Occupational Safety and Health criteria. We identified a substantial high-risk subgroup of PLD users (22% of participants, daily use ⩾2 h at ⩾91 dB) in which pure tone audiometry showed increased hearing thresholds at 4000 and 6000 Hz, potentially indicating an early manifestation of noise-induced hearing loss (NIHL). Conclusions: These findings suggest that preventive measures may be warranted to prevent a future increase of clinically relevant NIHL among heavy users of PLDs.

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