EFFECT OF SUPPLEMENTED INTAKE OF DOCOSAHEXAENOIC AND EICOSAPENTAENOIC FATTY ACIDS ON VENTRICULAR ARRHYTHMIAS IN CORONARY HEART DISEASE PATIENT'S WITH IMPLANTABLE CARDIOVERTER DEFIBRILLATOR

Background When implantable cardioverter defibrillator (ICD) battery is depleted most patients undergo generator replacement (GR) even in the absence of persistent ICD indication. The aim of this study was to assess the incidence of ventricular arrhythmias and the overall prognosis of patients with and without persistent ICD indication undergoing GR. Predictors of 1‐year mortality were also analyzed. Methods and Results Patients with structural heart disease implanted with primary prevention ICD undergoing GR were included. Patients were stratified based on the presence/absence of persistent ICD indication (left ventricular ejection fraction ≤35% at the time of GR and/or history of appropriate ICD therapies during the first generator's life). The study included 371 patients (82% male, 40% with ischemic heart disease). One third of patients (n=121) no longer met ICD indication at the time of GR. During a median follow‐up of 34 months after GR patients without persistent ICD indication showed a significantly lower incidence of appropriate ICD shocks (1.9% versus 16.2%, P <0.001) and ICD therapies. 1‐year mortality was also significantly lower in patients without persistent ICD indication (1% versus 8.3%, P =0.009). At multivariable analysis permanent atrial fibrillation, chronic advanced renal impairment, age >80, and persistent ICD indication were found to be significant predictors of 1‐year mortality. Conclusions Patients without persistent ICD indication at the time of GR show a low incidence of appropriate ICD therapies after GR. Persistent ICD indication, atrial fibrillation, advanced chronic renal disease, and age >80 are significant predictors of 1‐year mortality. Our findings enlighten the need of performing a comprehensive clinical reevaluation of ICD patients at the time of GR.

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Clinical variables predicting inappropriate use of implantable cardioverter-defibrillator in patients with coronary heart disease or nonischemic dilated cardiomyopathy

The American Journal of Cardiology ◽

10.1016/j.amjcard.2004.09.017 ◽

2005 ◽

Vol 95 (2) ◽

pp. 271-274 ◽

Cited By ~ 33

Author(s):

Dominic A.M.J. Theuns ◽

A. Peter J. Klootwijk ◽

Maarten L. Simoons ◽

Luc J. Jordaens

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Dilated Cardiomyopathy ◽

Implantable Cardioverter Defibrillator ◽

Cardioverter Defibrillator ◽

Clinical Variables ◽

Inappropriate Use ◽

Nonischemic Dilated Cardiomyopathy

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Automatic implantable cardioverter defibrillator implantation for malignant ventricular arrhythmias associated with congential heart disease

The American Journal of Cardiology ◽

10.1016/0002-9149(89)91093-x ◽

1989 ◽

Vol 63 (1) ◽

pp. 118-119 ◽

Cited By ~ 15

Author(s):

Mary A. Kral ◽

Henry M. Spotnitz ◽

Alan Hordof ◽

J.Thomas Bigger ◽

Jonathan S. Steinberg ◽

...

Keyword(s):

Heart Disease ◽

Implantable Cardioverter Defibrillator ◽

Ventricular Arrhythmias ◽

Cardioverter Defibrillator ◽

Implantable Cardioverter Defibrillator Implantation ◽

Congential Heart Disease ◽

Automatic Implantable Cardioverter Defibrillator

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Comparison of effectiveness of implantable cardioverter defibrillator in patients with idiopathic dilated cardiomyopathy versus those with proved coronary heart disease

The American Journal of Cardiology ◽

10.1016/j.amjcard.2003.07.041 ◽

2003 ◽

Vol 92 (10) ◽

pp. 1227-1230 ◽

Cited By ~ 1

Author(s):

Alejandro Cuesta ◽

Lluís Mont ◽

Ulises Rogel ◽

Mariana Valentino ◽

Mariona Matas ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Dilated Cardiomyopathy ◽

Implantable Cardioverter Defibrillator ◽

Idiopathic Dilated Cardiomyopathy ◽

Cardioverter Defibrillator ◽

Comparison Of Effectiveness

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Recent advances in the management of ventricular tachyarrhythmias

F1000Research ◽

10.12688/f1000research.11202.1 ◽

2017 ◽

Vol 6 ◽

pp. 1027 ◽

Cited By ~ 3

Author(s):

Syeda Atiqa Batul ◽

Brian Olshansky ◽

John D. Fisher ◽

Rakesh Gopinathannair

Keyword(s):

Heart Disease ◽

Implantable Cardioverter Defibrillator ◽

Ventricular Arrhythmias ◽

Symptom Relief ◽

Structural Heart Disease ◽

Left Ventricular ◽

Cardioverter Defibrillator ◽

Arrhythmic Death ◽

Recent Advances ◽

Cardiovascular Morbidity And Mortality

Ventricular arrhythmias are an important cause of cardiovascular morbidity and mortality, particularly in those with structural heart disease, inherited cardiomyopathies, and channelopathies. The goals of ventricular arrhythmia management include symptom relief, improving quality of life, reducing implantable cardioverter defibrillator shocks, preventing deterioration of left ventricular function, reducing risk of arrhythmic death, and potentially improving overall survival. Guideline-directed medical therapy and implantable cardioverter defibrillator implantation remain the mainstay of therapy to prevent sudden cardiac death in patients with ventricular arrhythmias in the setting of structural heart disease. Recent advances in imaging modalities and commercial availability of genetic testing panels have enhanced our mechanistic understanding of the disease processes and, along with significant progress in catheter-based ablative therapies, have enabled a tailored and more effective management of drug-refractory ventricular arrhythmias. Several gaps in our knowledge remain and require further research. In this article, we review the recent advances in the diagnosis and management of ventricular arrhythmias.

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P1530 False negative detections of ventricular arrhythmias in implantable cardioverter-defibrillator

European Heart Journal ◽

10.1016/s0195-668x(03)94668-9 ◽

2003 ◽

Vol 24 (5) ◽

pp. 276

Author(s):

T KROLAK

Keyword(s):

Implantable Cardioverter Defibrillator ◽

Ventricular Arrhythmias ◽

False Negative ◽

Cardioverter Defibrillator

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Identification of High-risk Patients for Implantable Cardioverter–Defibrillator Therapy in Asia

Asia Pacific Cardiology ◽

10.15420/apc.2011:3:1:77 ◽

2011 ◽

Vol 3 (1) ◽

pp. 77

Author(s):

Cyril YK Ko ◽

Jeffrey WH Fung ◽

◽

Keyword(s):

Heart Disease ◽

Implantable Cardioverter Defibrillator ◽

Asian Population ◽

Structural Heart Disease ◽

Medical Problem ◽

Western World ◽

Asian Countries ◽

Cardioverter Defibrillator ◽

Asian Patients ◽

Risk Patients

Sudden cardiac death (SCD) is a serious medical problem worldwide. Multiple landmark studies have demonstrated the benefit of implantable cardioverter–defibrillator (ICD) therapy in preventing SCD in at-risk patients. Although the data available in Asia are limited, the disease pattern seems to be different from that in the western world. The Asian population seems to have a lower incidence of SCD. Coronary heart disease, which is the major underlying cause of SCD in the west, may play a less important role in Asian countries. In addition, non-structural heart disease seems to be a more prevalent cause of SCD in Asia. It is thus questionable whether the results of ICD trials can be applied directly to Asian countries, as most of these trials seldom recruited Asian patients. This article will review SCD in Asia, focusing on the epidemiology and risk factors for SCD in Asia and highlighting some unique features that may be different from those seen in the western world.

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