SEDENTARY BEHAVIOR IS ASSOCIATED WITH CORONARY ARTERY CALCIFICATION IN THE DALLAS HEART STUDY

Objective.Urate may have effects on vascular remodeling and atherosclerosis. We had shown an association between serum uric acid (SUA) and carotid atherosclerotic plaques. Inflammation and vascular remodeling in atherosclerosis promote coronary artery calcification (CAC), a preclinical marker for atherosclerosis. Here, we examined whether SUA is associated with CAC, using the same study sample and methods as for our previous carotid atherosclerosis study.Methods.The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. Participants were recruited from population-based cohorts in the US states of Massachusetts, North Carolina, Minnesota, Utah, and Alabama. CAC was assessed with helical computed tomography (CT). We conducted sex-specific and family-cluster analyses, as well as additional analyses among persons without risk factors related to both cardiovascular disease and hyperuricemia, adjusting for potential confounders as we had in the previous study of carotid atherosclerosis.Results.For the CAC study, 2412 subjects had both SUA and helical CT results available (55% women, age 58 ± 13 yrs, body mass index 27.6 ± 5.3). We found no association of SUA with CAC in men or women [OR in men: 1.0, 1.11, 0.86, 0.90; women: 1.0, 0.83, 1.00, 0.87 for increasing categories of SUA: < 5 (referent group), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively], nor in subgroup analyses.Conclusion.Replicating the methods used to demonstrate an association of SUA with carotid atherosclerosis did not reveal any association between SUA and CAC, suggesting that SUA likely does not contribute to atherosclerosis through effects on arterial calcification. The possibility that urate has divergent pathophysiologic effects on atherosclerosis and artery calcification merits further study.

Download Full-text

Association of depressive symptom severity with coronary artery calcium: The Dallas heart study

Journal of Affective Disorders ◽

10.1016/j.jad.2020.07.042 ◽

2020 ◽

Vol 276 ◽

pp. 267-271

Author(s):

Amber Khan ◽

Jayme Palka ◽

Parag H. Joshi ◽

Amit Khera ◽

E. Sherwood Brown

Keyword(s):

Depressive Symptom ◽

Coronary Artery ◽

Coronary Artery Calcium ◽

Symptom Severity ◽

Heart Study ◽

Depressive Symptom Severity ◽

Dallas Heart Study

Download Full-text

INFLAMMATORY AND HEMOSTATIC RISK FACTORS AND CORONARY ARTERY CALCIFICATION IN WOMEN OF BLACK AND WHITE RACE IN THE MENOPAUSAL TRANSITION: THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION (SWAN) HEART STUDY

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)61410-8 ◽

2014 ◽

Vol 63 (12) ◽

pp. A1410

Author(s):

Norman C. Wang ◽

Karen A. Matthews ◽

Emma JM Barinas-Mitchell ◽

Chung-Chou H. Chang ◽

Samar R. El Khoudary

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

Women’S Health ◽

Women's Health ◽

Coronary Artery Calcification ◽

Menopausal Transition ◽

White Race ◽

Black And White ◽

Heart Study

Download Full-text

Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)

American Heart Journal ◽

10.1016/j.ahj.2005.05.004 ◽

2006 ◽

Vol 151 (3) ◽

pp. 706-711 ◽

Cited By ~ 30

Author(s):

Kathryn P. Burdon ◽

Carl D. Langefeld ◽

Stephanie R. Beck ◽

Lynne E. Wagenknecht ◽

J. Jeffrey Carr ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Calcification ◽

Heart Study ◽

Cd40 Gene ◽

Diabetes Heart Study

Download Full-text

Physical Aggression and Coronary Artery Calcification: A North Texas Healthy Heart Study

International Journal of Behavioral Medicine ◽

10.1007/s12529-021-09989-7 ◽

2021 ◽

Author(s):

Kimberly G. Fulda ◽

Karen L. Roper ◽

Claude H. Dotson ◽

Roberto Cardarelli

Keyword(s):

Coronary Artery ◽

Physical Aggression ◽

Coronary Artery Calcification ◽

North Texas ◽

Heart Study

Download Full-text

Association Between Ambulatory Blood Pressure and Coronary Artery Calcification

Hypertension ◽

10.1161/hypertensionaha.121.17064 ◽

2021 ◽

Author(s):

Yiyi Zhang ◽

Joseph E. Schwartz ◽

Byron C. Jaeger ◽

Jaejin An ◽

Brandon K. Bellows ◽

...

Keyword(s):

Blood Pressure ◽

Coronary Artery ◽

Coronary Artery Calcification ◽

Subclinical Atherosclerosis ◽

Agatston Score ◽

Ambulatory Bp Monitoring ◽

Heart Study ◽

Artery Disease ◽

Prevalence Ratios ◽

Multivariable Adjustment

High blood pressure (BP) based on measurements obtained in the office setting has been associated with the presence and level of coronary artery calcification (CAC)—a measure of subclinical atherosclerosis. We studied the association between out-of-office BP and CAC among 557 participants who underwent 24-hour ambulatory BP monitoring at visit 1 in 2000–2004 and a computed tomography scan at visit 2 in 2005–2008 as part of the JHS (Jackson Heart Study)—a community-based cohort of African American adults. Mean awake, asleep, and 24-hour BP were calculated for each participant. Among participants included in this analysis, 279 (50%) had any CAC defined by an Agatston score >0. After multivariable adjustment including office systolic BP (SBP), the prevalence ratios for any CAC comparing the highest versus the lowest quartiles of SBP on ambulatory BP monitoring were 1.08 (95% CI, 0.84–1.39) for awake SBP, 1.32 (95% CI, 1.01–1.74) for asleep SBP, and 1.19 (95% CI, 0.91–1.55) for 24-hour SBP. After multivariable adjustment including office diastolic BP, the prevalence ratios for any CAC comparing the highest versus the lowest quartiles of awake, asleep, and 24-hour diastolic BP were 1.27 (95% CI, 1.02–1.59), 1.29 (95% CI, 1.02–1.64), and 1.25 (95% CI, 0.99–1.59), respectively. The current results suggest that higher asleep SBP and higher awake and asleep diastolic BP may be risk factors for subclinical atherosclerosis and underscore the potential role of ambulatory BP monitoring in identifying individuals at high risk for coronary artery disease.

Download Full-text

Abstract 684: Principal Component Analysis Identifies Lipoprotein Subfractions Associated with Coronary Artery Calcification in a Young High Cardiometabolic Risk Population: The Baptist Employee Healthy Heart Study

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.35.suppl_1.684 ◽

2015 ◽

Vol 35 (suppl_1) ◽

Author(s):

Emir Veledar ◽

Ehimen Aneni ◽

Chukwuemeka Osondu ◽

Oluseye Ogunmoroti ◽

Lare Roberson ◽

...

Keyword(s):

Principal Component Analysis ◽

Coronary Artery ◽

Coronary Artery Calcification ◽

Principal Component ◽

Component Analysis ◽

Data Sets ◽

Cvd Risk ◽

Lipoprotein Subfractions ◽

Heart Study ◽

Atherogenic Lipoprotein Phenotype

Introduction: There is limited evidence relating lipoprotein subfractions or their composite measures to subclinical markers of atherosclerosis. In this study, we tested whether combinations of lipoprotein subfractions independently predict the presence of Coronary Artery Calcification (CAC) among presumably healthy people with high cardiovascular disease (CVD) risk. Methods: Cardio IQ™ Ion Mobility lipoprotein fractionation was measured at baseline in 172 high CVD risk participants of the Baptist Employee Healthy Heart Study (BEHHS). Principal component analysis was used to check for eventual components of CVD risk. Using bootstrap techniques, we created 1000 data sets of size 5000 and analyzed results of logistic regression. Results: Three principal components (PC) accounted for 88% variability. PC1 represented an increase in all lipoprotein measures; PC2 a decrease in HDL, large and medium LDL with an increase in VLDL and small and very small LDL; PC3 an increase in HDL, and a decrease in LDL subfractions and large IDL particles. The adjusted odds ratios for the presence of CAC were: 1.01(0.98 - 1.03) for PC1, 1.22(1.17-1.27) for PC2 and 0.90 (0.85 - 0.97) for PC3. PC2 and PC3 were associated with p-values smaller than 0.05 in 100% and 88% of all models. Conclusion: PCA of lipoprotein subfractions identified 3 independent components of CVD risk. PC2, proxy for the “atherogenic lipoprotein phenotype”, was consistently associated with the presence of underlying coronary artery calcification. There is potential to explore how lipoprotein subfractions as determined by a safe, inexpensive blood test can be used to stratify CVD risk in younger but high risk individuals.

Download Full-text

Abstract 3490: Formal Comparison between absolute and relative cut points for Coronary Artery Calcification in At Intermediate Risk Community-Based Men and Women: The Framingham Heart Study

Circulation ◽

10.1161/circ.116.suppl_16.ii_790-b ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Udo Hoffmann ◽

Joseph M Massaro ◽

Caroline S Fox ◽

Emily Manders ◽

Christopher J O’Donnell

Keyword(s):

Coronary Artery ◽

Framingham Heart Study ◽

Coronary Artery Calcification ◽

Agatston Score ◽

Intermediate Risk ◽

Community Based ◽

Men And Women ◽

Cut Points ◽

Framingham Risk ◽

Heart Study

Background: Coronary artery calcification (CAC) may improve risk stratification of individuals at intermediate Framingham Risk. We determined the agreement between absolute and relative cut points to identify subjects with elevated CAC in individuals at intermediate Framingham Risk. Methods : The amount of CAC was quantified in 3238 participants from the Framingham Heart Study (FHS) Offspring and Third Generation cohorts (48% women, mean age 53 years) free of cardiovascular disease who underwent ECG triggered cardiac MDCT. We included subjects at intermediate Framingham risk, defined as 6 –20% ten year event risk, (n = 1177) and subjects free of cardiovascular risk factors (n = 1586). Distribution of CAC according to absolute (Agatston Score [AS] > 400) and relative (90 th percentile stratified by age as derived from the healthy reference subset) cut-points were determined for men and women Results: Among men with intermediate FRS, 17.7% had CAC above the 90 th percentile of the healthy referent sample, whereas 14% had CAC > 400. Similar findings were observed in women: 11.5% had CAC above the 90 th percentile of the healthy referent sample, whereas 2% had CAC > 400. Among all individuals at intermediate FRS Only 10.8% of subjects above the 90 th percentile had an AS < 400. Conclusions: The fraction of subjects with elevated CAC as determined by an AS > 400 is lower than subjects above the 90 th percentile especially among women at intermediate FRS in the community-based FHS. Overall, the agreement between absolute and relative cut points to identify subjects with elevated CAC is poor in this population. Prospective outcomes studies are necessary to test the hypothesis that relative rather than absolute cutpoints of CAC should be used to further stratify subjects at intermediate risk.

Download Full-text