Abstract 3490: Formal Comparison between absolute and relative cut points for Coronary Artery Calcification in At Intermediate Risk Community-Based Men and Women: The Framingham Heart Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Udo Hoffmann ◽  
Joseph M Massaro ◽  
Caroline S Fox ◽  
Emily Manders ◽  
Christopher J O’Donnell
Keyword(s):  
Coronary Artery ◽  
Framingham Heart Study ◽  
Coronary Artery Calcification ◽  
Agatston Score ◽  
Intermediate Risk ◽  
Community Based ◽  
Men And Women ◽  
Cut Points ◽  
Framingham Risk ◽  
Heart Study

Background: Coronary artery calcification (CAC) may improve risk stratification of individuals at intermediate Framingham Risk. We determined the agreement between absolute and relative cut points to identify subjects with elevated CAC in individuals at intermediate Framingham Risk. Methods : The amount of CAC was quantified in 3238 participants from the Framingham Heart Study (FHS) Offspring and Third Generation cohorts (48% women, mean age 53 years) free of cardiovascular disease who underwent ECG triggered cardiac MDCT. We included subjects at intermediate Framingham risk, defined as 6 –20% ten year event risk, (n = 1177) and subjects free of cardiovascular risk factors (n = 1586). Distribution of CAC according to absolute (Agatston Score [AS] > 400) and relative (90 th percentile stratified by age as derived from the healthy reference subset) cut-points were determined for men and women Results: Among men with intermediate FRS, 17.7% had CAC above the 90 th percentile of the healthy referent sample, whereas 14% had CAC > 400. Similar findings were observed in women: 11.5% had CAC above the 90 th percentile of the healthy referent sample, whereas 2% had CAC > 400. Among all individuals at intermediate FRS Only 10.8% of subjects above the 90 th percentile had an AS < 400. Conclusions: The fraction of subjects with elevated CAC as determined by an AS > 400 is lower than subjects above the 90 th percentile especially among women at intermediate FRS in the community-based FHS. Overall, the agreement between absolute and relative cut points to identify subjects with elevated CAC is poor in this population. Prospective outcomes studies are necessary to test the hypothesis that relative rather than absolute cutpoints of CAC should be used to further stratify subjects at intermediate risk.

Abstract P427: Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White-matter Injury in Asymptomatic Middle-aged Men: The Framingham Heart Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Harumitsu Suzuki ◽  
Kendra Davis-Plourde ◽  
Alexa Beiser ◽  
Katsuyuki Miura ◽  
Charles DeCarli ◽  
...  
Keyword(s):  
Coronary Artery ◽  
White Matter ◽  
Framingham Heart Study ◽  
Diffusion Tensor ◽  
Free Water ◽  
White Matter Injury ◽  
Brain Diseases ◽  
Agatston Score ◽  
Middle Aged ◽  
Heart Study

Introduction: Using magnetic resonance (MR) diffusion tensor imaging (DTI), we previously showed a cross-sectional association between carotid-femoral pulse wave velocity (CFPWV), a measure of aortic stiffness, and subtle white-matter injury in clinically asymptomatic middle-age adults. Although coronary artery calcification (CAC) predicted cerebral small vessel diseases evident in conventional MR technique in some studies, it remains unclear whether CAC predicts DTI-based subtle white matter injuries. Hypothesis: CAC and CFPWV are associated with global measures of subtle white-matter injury in middle-aged adults free of clinical brain diseases. Methods: We studied third-generation participants of the Framingham Heart Study who were assessed for CAC (2002-2005), CFPWV, and brain DTI (2009-2013). After excluding prevalent stroke, dementia, other neurological conditions, or those with missing data, 1052 participants (women, 45.4%, mean age: 45.4 years) were analyzed. Two DTI-based outcomes were examined (average within voxels from the white matter mask): free water (FW) and FW-corrected fractional anisotropy (FA). Using linear regression, we calculated slopes of the outcomes per 20-80 th percentiles higher CAC (log-transformed Agatston score) or CFPWV (negative inverse) after adjustment for age and age squared at CAC or CFPWV, time between at CAC/CFPWV and DTI exam, systolic blood pressure, diabetes, total cholesterol, medication(s) for hypertension or dyslipidemia, smoking, and total cranial volume. Results: After multivariable adjustment, in men, CAC was associated only with FA (p=0.033), whereas CFPWV was associated only with FW (p=0.030) ( Figure ). No associations were observed in women. Conclusions: In men, CAC assessed at >7.5 years earlier was associated with worse FA, while CFPWV assessed at 1.7 years earlier was associated with worse FW. CAC may be a sensitive maker to predict subtle white-matter injury in asymptomatic middle-aged men.

scholarly journals Association Between Ambulatory Blood Pressure and Coronary Artery Calcification

Hypertension ◽  
2021 ◽  
Author(s):  
Yiyi Zhang ◽  
Joseph E. Schwartz ◽  
Byron C. Jaeger ◽  
Jaejin An ◽  
Brandon K. Bellows ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Subclinical Atherosclerosis ◽  
Agatston Score ◽  
Ambulatory Bp Monitoring ◽  
Heart Study ◽  
Artery Disease ◽  
Prevalence Ratios ◽  
Multivariable Adjustment

High blood pressure (BP) based on measurements obtained in the office setting has been associated with the presence and level of coronary artery calcification (CAC)—a measure of subclinical atherosclerosis. We studied the association between out-of-office BP and CAC among 557 participants who underwent 24-hour ambulatory BP monitoring at visit 1 in 2000–2004 and a computed tomography scan at visit 2 in 2005–2008 as part of the JHS (Jackson Heart Study)—a community-based cohort of African American adults. Mean awake, asleep, and 24-hour BP were calculated for each participant. Among participants included in this analysis, 279 (50%) had any CAC defined by an Agatston score >0. After multivariable adjustment including office systolic BP (SBP), the prevalence ratios for any CAC comparing the highest versus the lowest quartiles of SBP on ambulatory BP monitoring were 1.08 (95% CI, 0.84–1.39) for awake SBP, 1.32 (95% CI, 1.01–1.74) for asleep SBP, and 1.19 (95% CI, 0.91–1.55) for 24-hour SBP. After multivariable adjustment including office diastolic BP, the prevalence ratios for any CAC comparing the highest versus the lowest quartiles of awake, asleep, and 24-hour diastolic BP were 1.27 (95% CI, 1.02–1.59), 1.29 (95% CI, 1.02–1.64), and 1.25 (95% CI, 0.99–1.59), respectively. The current results suggest that higher asleep SBP and higher awake and asleep diastolic BP may be risk factors for subclinical atherosclerosis and underscore the potential role of ambulatory BP monitoring in identifying individuals at high risk for coronary artery disease.

scholarly journals Associations of magnesium intake with coronary artery calcification in the Framingham Heart Study

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Adela Hruby ◽  
Christopher J. O'Donnell ◽  
Paul F. Jacques ◽  
James B. Meigs ◽  
Richard J. Wood ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Framingham Heart Study ◽  
Coronary Artery Calcification ◽  
Magnesium Intake ◽  
Heart Study

Abstract P325: Association of Risk Factors and Extra-coronary Atherosclerosis with Progression of Coronary Artery Calcification in the Framingham Heart Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Oyere K Onuma ◽  
Karol M Pencina ◽  
Joseph M Massaro ◽  
Udo Hoffman ◽  
Christopher J O'Donnell
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Framingham Heart Study ◽  
Coronary Artery Calcification ◽  
Ct Scanning ◽  
Linear Regression Models ◽  
Cvd Risk ◽  
Abdominal Aortic ◽  
Heart Study

Background: Progression of coronary artery calcification (CAC) is associated with future incidence of adverse cardiovascular disease. However, the interplay of CAC progression and atherosclerosis in different vascular beds has been less studied. We tested for the association of risk factors and baseline abdominal aortic calcification (AAC) with CAC progression in a large community cohort. Methods: We determined risk factors, baseline AAC/CAC, and CAC progression in a sample of 1994 asymptomatic white participants from the Framingham Heart Study (FHS) who had undergone serial CT scanning within an average of 6.1 years. The primary outcomes were: (a) incident calcification (CAC > 0) in participants free of CAC at baseline; and (b) absolute progression of CAC (CAC follow-up > CAC baseline) in participants with detectable baseline CAC. To test the effect of risk factors and baseline AAC/CAC on CAC progression, we employed multivariable stepwise logistic and linear regression models of CAC progression with/without AAC, adjusted for traditional CVD risk factors. Results: There were 1118 participants free of CAC at the baseline scan, of which 18.8% developed CAC in the follow-up scan. Of the 776 participants with detectable CAC at baseline, 84.9% developed progression of baseline CAC. In both subsets, AAC was a highly significant predictor of CAC incidence or progression, independent of other risk factors. Of note, the stepwise model including baseline AAC as a candidate for entry resulted in the same set of non-AAC predictors of CAC incidence or progression as the model without AAC. Table 1 displays the final logistic regression results for the cohort free of CAC. The AUC improved to 0.738 compared to an AUC of 0.722 for the model without AAC (p=0.002). Conclusion: AAC is a strong independent predictor of CAC progression determined by incident CAC and CAC progression. Addition of AAC to the model that predicts incident CAC improves discrimination in a cohort free of baseline CAC.

scholarly journals Sugar-Sweetened Beverage Consumption and Calcified Atherosclerotic Plaques in the Coronary Arteries: The NHLBI Family Heart Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1775
Author(s):  
Yash R. Patel ◽  
Tasnim F. Imran ◽  
R. Curtis Ellison ◽  
Steven C. Hunt ◽  
John Jeffrey Carr ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Coronary Arteries ◽  
Subclinical Atherosclerosis ◽  
Agatston Score ◽  
Sugar Sweetened Beverage ◽  
Cut Points ◽  
Sweetened Beverage ◽  
Family Heart Study ◽  
Heart Study ◽  
Nhlbi Family Heart Study

Background: Sugar-sweetened beverage (SSB) intake is associated with higher risk of weight gain, diabetes, hypertension, cardiovascular disease, and cardiovascular mortality. However, the association of SSB with subclinical atherosclerosis in the general population is unknown. Objective: Our primary objective was to investigate the association between SSB intake and prevalence of atherosclerotic plaque in the coronary arteries in The National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Methods: We studied 1991 participants of the NHLBI Family Heart Study without known coronary heart disease. Intake of SSB was assessed through a semi-quantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac Computed Tomography (CT) and prevalent CAC was defined as an Agatston score ≥100. We used generalized estimating equations to calculate adjusted prevalence ratios of CAC. A sensitivity analysis was also performed at different ranges of cut points for CAC. Results: Mean age and body mass index (BMI) were 55.0 years and 29.5 kg/m2, respectively, and 60% were female. In analysis adjusted for age, sex, BMI, smoking, alcohol use, physical activity, energy intake, and field center, higher SSB consumption was not associated with higher prevalence of CAC [prevalence ratio (95% confidence interval) of: 1.0 (reference), 1.36 (0.70–2.63), 1.69 (0.93–3.09), 1.21 (0.69–2.12), 1.05 (0.60–1.84), and 1.58 (0.85–2.94) for SSB consumption of almost never, 1–3/month, 1/week, 2–6/week, 1/day, and ≥2/day, respectively (p for linear trend 0.32)]. In a sensitivity analysis, there was no evidence of association between SSB and prevalent CAC when different CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions: These data do not provide evidence for an association between SSB consumption and prevalent CAC in adult men and women.

Muscle mass and fat mass in relation to bone mineral density in very old men and women: the Framingham Heart Study

1998 ◽  
Vol 49 (5-6) ◽  
pp. 745-747 ◽  
Author(s):  
M. Visser ◽  
D.P. Kiel ◽  
J. Langlois ◽  
M.T. Hannan ◽  
D.T. Felson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Muscle Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Framingham Heart Study ◽  
Mineral Density ◽  
Men And Women ◽  
Very Old ◽  
Heart Study ◽  
Old Men

scholarly journals Plasma F2-Isoprostanes and Coronary Artery Calcification: The CARDIA Study

2005 ◽  
Vol 51 (1) ◽  
pp. 125-131 ◽  
Author(s):  
Myron Gross ◽  
Michael Steffes ◽  
David R Jacobs ◽  
Xinhua Yu ◽  
Linda Lewis ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Early Development ◽  
Coronary Artery Calcification ◽  
Continuous Variable ◽  
Oxidation Products ◽  
Gas Chromatography Mass Spectrometry ◽  
Agatston Score ◽  
Reactive Protein ◽  
Increased Risk ◽  
Coronary Artery Atherosclerosis

Abstract Background: Oxidation of lipids in lipoproteins and cells may initiate and enhance the early development of cardiovascular disease. Method and Results: We assayed F2-isoprostanes, oxidation products of arachidonic acid, by gas chromatography–mass spectrometry in a biracial cohort of 2850 young healthy adult men and women. Coronary artery calcification (CAC), a component of coronary artery atherosclerosis, was detectable in 10% of the cohort and appeared to be in its initial stages (Agatston scores &lt;20 in 47% and &lt;100 in 83% of CAC-positive participants). After adjusting for sex, clinical site, age, and race, the presence of any CAC was 24% more likely among those with high vs low concentrations of F2-isoprostanes [odds ratio (OR) = 1.24 per 92.2 pmol/L (32.7 ng/L; 1 SD of F2-isoprostanes); 95% confidence interval (CI), 1.09–1.41]. The OR was only slightly attenuated [1.18 per 92.2 pmol/L (32.7 ng/L); CI, 1.02–1.38] after further adjustment for body mass index, smoking, serum lipids, C-reactive protein, antioxidant supplementation use, diabetes, and blood pressure. As a continuous variable, the Agatston score increased by 6.9% per 92.2 pmol/L (32.7 ng/L) of F2-isoprostane concentration (P &lt;0.01). Whereas CAC prevalence was lower in women than men, mean (SD), F2-isoprostanes were higher in women {190 (108.9) pmol/L [67.4 (38.6) ng/L]} than in men {140.4 (55.6) pmol/L [49.8 (19.7) ng/L]}. Nevertheless, F2-isoprostanes were associated with an increased risk of CAC in both sexes. Conclusion: This association between increased concentrations of circulating F2-isoprostanes and CAC in young healthy adults supports the hypothesis that oxidative damage is involved in the early development of atherosclerosis.

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